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公开(公告)号:US08143288B2
公开(公告)日:2012-03-27
申请号:US11446788
申请日:2006-06-05
申请人: Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
发明人: Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
IPC分类号: A61K31/444 , A61K31/4439 , A61K31/42 , A61K31/416 , A61K31/4025 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号: C07D207/16 , C07D207/22 , C07D207/277 , C07D209/42 , C07D211/60 , C07D263/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要: Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
摘要翻译: 描述具有式I结构的化合物。 该化合物可以抑制丙型肝炎病毒(HCV)复制,特别是可以抑制HCV NS5A蛋白的功能。
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公开(公告)号:US20100080772A1
公开(公告)日:2010-04-01
申请号:US12569466
申请日:2009-09-29
申请人: Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
发明人: Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
IPC分类号: A61K38/20 , A61K38/21 , A61K31/70 , A61K31/7088 , A61K31/5377 , A61K31/47 , C07D413/04 , C07D217/00 , C07D215/00
CPC分类号: C07D207/16 , A61K31/401 , A61K31/4015 , A61K31/47 , A61K31/5377 , A61K31/70 , A61K31/7088 , C07C233/62 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/14 , C07D487/08
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US08383094B2
公开(公告)日:2013-02-26
申请号:US12569466
申请日:2009-09-29
申请人: Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
发明人: Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
IPC分类号: A61K38/20 , A61K38/21 , A61K38/47 , C07D413/04 , C07D217/00 , C07D215/00
CPC分类号: C07D207/16 , A61K31/401 , A61K31/4015 , A61K31/47 , A61K31/5377 , A61K31/70 , A61K31/7088 , C07C233/62 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/14 , C07D487/08
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20080299075A1
公开(公告)日:2008-12-04
申请号:US12029680
申请日:2008-02-12
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , A61K31/4178 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K31/7088 , A61K38/16 , A61P31/12
CPC分类号: C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US20080044379A1
公开(公告)日:2008-02-21
申请号:US11835485
申请日:2007-08-08
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K38/20 , A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , A61K38/21 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02 , C07D237/02 , C07D233/54 , C07D221/00 , A61P31/12 , A61K31/4523 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/7052
CPC分类号: C07D401/14 , C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20120328570A1
公开(公告)日:2012-12-27
申请号:US13606231
申请日:2012-09-07
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K31/4178 , C07D401/14 , A61K31/4545 , C07D413/14 , A61K31/5377 , A61P31/14 , A61K31/695 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K31/713 , C07D403/14 , C07F7/10
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US07759495B2
公开(公告)日:2010-07-20
申请号:US11835524
申请日:2007-08-08
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: C07D233/02 , A01N43/50
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US07704992B2
公开(公告)日:2010-04-27
申请号:US12358308
申请日:2009-01-23
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: A61K31/55 , A61K31/4155 , C07D223/18 , C07D233/54
CPC分类号: C07D403/14 , C07D405/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US08288562B2
公开(公告)日:2012-10-16
申请号:US12786703
申请日:2010-05-25
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: C07D233/02 , A01N43/50
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20100233120A1
公开(公告)日:2010-09-16
申请号:US12786703
申请日:2010-05-25
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K38/20 , C07D403/14 , A61K31/501 , A61K31/506 , A61K31/4439 , C07D401/14 , A61K38/21 , A61K31/7056 , A61K31/713 , A61K31/437 , A61P31/22
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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