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    Array cytometry
    1.
    发明授权
    Array cytometry 失效
    阵列细胞计数

    公开(公告)号：US06958245B2

    公开(公告)日：2005-10-25

    申请号：US09995894

    申请日：2001-11-28

    Applicant: Michael Seul ,  Alice X. Li

    Inventor： Michael Seul ,  Alice X. Li

    IPC: B01J19/00 ,  B01L3/00 ,  C07B61/00 ,  C12Q1/68 ,  G01N15/14 ,  G01N33/543 ,  G02B3/00 ,  G21K1/00 ,  H05H3/04 ,  G01N33/546

    CPC classification number: G02B3/0056 ,  B01J19/0046 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0454 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/00 ,  G01N15/1463 ,  G01N33/54313 ,  G01N2015/149 ,  G02B3/0012 ,  H05H3/04 ,  Y10T436/25125 ,  C12Q2565/501 ,  C12Q2563/155 ,  C12Q2565/607

    Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on the combination of three functional elements, the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination.

    Abstract translation: 一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。 表面附近颗粒的光控电动组装取决于三个功能元素的组合，即AC电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。 本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。 本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。 此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。 本发明还涉及一种方法和装置，以响应于时间和空间上变化的电场以及投射的照明模式，引导横向运动并将组件引导到半导体表面上的平面阵列阵列。

    Encoded beads having oligonucleotides attached in arrays on a patterned surface
    6.
    发明授权
    Encoded beads having oligonucleotides attached in arrays on a patterned surface 有权
    具有寡核苷酸的编码珠在阵列上附着在图案化表面上

    公开(公告)号：US08124402B2

    公开(公告)日：2012-02-28

    申请号：US11436717

    申请日：2006-05-17

    Applicant: Michael Seul

    Inventor： Michael Seul

    IPC: C12M1/36 ,  G01N15/06 ,  C07H21/04

    CPC classification number: C40B50/18 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00448 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B60/14 ,  C12Q2565/501 ,  C12Q2563/155 ,  C12Q2565/607

    Abstract: A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.

    Abstract translation: 一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面上操纵胶体颗粒和生物分子的方法和装置。 表面附近颗粒的光控电动组装取决于三个功能元件的组合：交流电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。 本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。 本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。 此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装的光学部件的程序。

    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES
    7.
    发明申请
    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US20110251093A1

    公开(公告)日：2011-10-13

    申请号：US13084869

    申请日：2011-04-12

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: C40B30/04

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    Analysis, secure access to, and transmission of array images
    8.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US07940968B2

    公开(公告)日：2011-05-10

    申请号：US11439599

    申请日：2006-05-23

    Applicant: Michael Seul ,  Xiongwu Xia ,  Chiu Chau

    Inventor： Michael Seul ,  Xiongwu Xia ,  Chiu Chau

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    Correcting an assay image of an array of signals generated from a multiplexed hybridization-mediated assay
    10.
    发明授权
    Correcting an assay image of an array of signals generated from a multiplexed hybridization-mediated assay 有权
    校正由多重杂交介导的测定产生的信号阵列的测定图像

    公开(公告)号：US07771939B2

    公开(公告)日：2010-08-10

    申请号：US11439694

    申请日：2006-05-23

    Applicant: Ghazala Hashmi ,  Michael Seul

    Inventor： Ghazala Hashmi ,  Michael Seul

    IPC: C12Q1/68 ,  C12M1/34 ,  G01N33/00 ,  G01N33/53 ,  C07H21/04 ,  G01N33/50

    CPC classification number: C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q2600/156 ,  C12Q2600/16 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/143333 ,  C12Q2565/543 ,  C12Q2563/107 ,  C12Q2565/501

    Abstract: Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.

    Abstract translation: 描述了测定设计和测定图像校正的方法，其可用于使用探针对阵列（在一个方面中，其中一个成员与特定突变体互补的突变和多态性）的多重遗传筛选（包括CF相关突变体和多态性） 多态等位基因和另一个成员与相应的野生型等位基因互补），其中探针与编码的颗粒结合（例如，珠粒），其中编码允许鉴定附着的探针。 该方法涉及通过选择探针和扩增子来避免交叉杂交，以及分离某些探针和扩增子的反应，其中超过同源性阈值。 还公开了使用背景图校正荧光图像的方法，其中颗粒还包含光编码系统。

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