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![Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase](/abs-image/US/2010/05/25/US07723368B2/abs.jpg.150x150.jpg)
1.发明授权Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase 失效用于抑制β-分泌酶的氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑啉酮化合物公开(公告)号：US07723368B2
公开(公告)日：2010-05-25
申请号：US12053086
申请日：2008-03-21
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
IPC分类号： A61K31/4166 , A61K31/4168 , C07D233/30
CPC分类号： C07D233/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的化合物和方法。
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![Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone Compounds For The Inhibition Of Beta-secretase](/abs-image/US/2010/07/01/US20100168194A1/abs.jpg.150x150.jpg)
2.发明申请Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone Compounds For The Inhibition Of Beta-secretase 审中-公开氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑酮化合物抑制β-分泌酶公开(公告)号：US20100168194A1
公开(公告)日：2010-07-01
申请号：US12721086
申请日：2010-03-10
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
IPC分类号： A61K31/4166 , C07D233/30 , A61P25/28
CPC分类号： C07D233/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的化合物和方法。
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![AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS](/abs-image/US/2009/02/12/US20090042964A1/abs.jpg.150x150.jpg)
3.发明申请AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS 审中-公开氨基-5- [取代-4-（二氟甲基）苯基] -5-苯基咪唑烷酮化合物作为β-分泌酶抑制剂公开(公告)号：US20090042964A1
公开(公告)日：2009-02-12
申请号：US12052098
申请日：2008-03-20
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , William R. Solvibile , Koi Michele Morris , Schuyler Adam Antane , Ji-In Kim , Robert Emmett McDevitt
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , William R. Solvibile , Koi Michele Morris , Schuyler Adam Antane , Ji-In Kim , Robert Emmett McDevitt
IPC分类号： A61K31/4168 , C07D233/32 , A61P25/00
CPC分类号： C07D233/88
摘要： The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的2-氨基-5- [取代-4-（二氟甲氧基）苯基] -5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β 淀粉样沉积物和神经原纤维缠结。
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![AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE](/abs-image/US/2009/02/19/US20090048320A1/abs.jpg.150x150.jpg)
4.发明申请AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE 失效氨基-5- [4-（二氟甲基）苯基] -5-苯基咪唑烷酮化合物用于抑制β-分泌酶公开(公告)号：US20090048320A1
公开(公告)日：2009-02-19
申请号：US12053086
申请日：2008-03-21
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim
IPC分类号： A61K31/4168 , C07D233/46 , C12N9/00 , A61P25/28
CPC分类号： C07D233/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的化合物和方法。
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公开(公告)号：US07241791B2
公开(公告)日：2007-07-10
申请号：US10670646
申请日：2003-09-24
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , C07D409/04
摘要： This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.
摘要翻译： 本发明提供具有以下结构的式I或II的化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9， SUB＆gt;和R 10＆gt;如说明书中所定义或其药学上可接受的盐，其可用于治疗疾病的炎性成分，并且特别可用于治疗动脉粥样硬化，心肌梗塞，充血性心脏 失败，炎症性肠病，关节炎，II型糖尿病和自身免疫疾病如多发性硬化和风湿性关节炎。
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