-
公开(公告)号:US07563796B2
公开(公告)日:2009-07-21
申请号:US11332732
申请日:2006-01-13
申请人: Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
发明人: Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
IPC分类号: C07D487/04 , A61K31/519 , A61P25/28
CPC分类号: C07D487/04
摘要: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的氨基咪唑啉酮化合物。还提供了用于抑制β-分泌酶(BACE)和治疗β-淀粉样沉积物和神经原纤维缠结的组合物和方法。
-
公开(公告)号:US20090253716A1
公开(公告)日:2009-10-08
申请号:US12487395
申请日:2009-06-18
申请人: Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
发明人: Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
IPC分类号: A61K31/519 , C07D487/04 , A61P25/28
CPC分类号: C07D487/04
摘要: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的氨基咪唑啉酮化合物。还提供了用于抑制β-分泌酶(BACE)和治疗β-淀粉样沉积物和神经原纤维缠结的组合物和方法。
-
3.Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation 失效
标题翻译: 氨基-5-(5元)杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途公开(公告)号:US07417047B2
公开(公告)日:2008-08-26
申请号:US11478122
申请日:2006-06-29
申请人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号: A61K31/4178 , A61K31/4439 , A61K31/506 , C07D403/04 , C07D401/14
CPC分类号: C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶(BACE)和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
-
4.AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION 失效
标题翻译: AMINO-5-(5-MEMBERED)异星形霉素化合物及其用于β-分泌酶调节的用途公开(公告)号:US20080306091A1
公开(公告)日:2008-12-11
申请号:US12180795
申请日:2008-07-28
申请人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号: C07D403/10 , A61K31/506 , C07D401/10 , A61K31/4439 , A61K31/4152 , A61K31/4168 , A61K31/4178 , C07D233/96 , C07D231/10 , C07D413/10 , A61K31/5377
CPC分类号: C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译: 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶(BACE)和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法
-
5.Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation 审中-公开
标题翻译: 氨基-5-(5元)杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途公开(公告)号:US20100168106A1
公开(公告)日:2010-07-01
申请号:US12719606
申请日:2010-03-08
申请人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号: A61K31/5377 , C07D403/14 , A61K31/506 , C07D401/14 , A61K31/4439 , A61K31/497 , C07D413/14 , A61P25/28
CPC分类号: C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译: 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制和分泌(BACE)和治疗和淀粉样沉积物和神经原纤维缠结的方法
-
6.Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation 失效
标题翻译: 氨基-5-(5元)杂芳基咪唑酮化合物及其用于分泌酶调节的用途公开(公告)号:US07705030B2
公开(公告)日:2010-04-27
申请号:US12180795
申请日:2008-07-28
申请人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号: A61K31/4178 , A61K31/4439 , A61K31/506 , C07D403/14 , C07D401/14 , C07D233/88
CPC分类号: C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了其用于抑制和分泌(BACE)和治疗和淀粉样蛋白沉积物和神经原纤维缠结的方法。
-
7.Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase 失效
标题翻译: 用于抑制β-分泌酶的氨基-5- [4-(二氟甲氧基)苯基] -5-苯基咪唑啉酮化合物公开(公告)号:US07423158B2
公开(公告)日:2008-09-09
申请号:US11526511
申请日:2006-09-25
申请人: Michael Sotirios Malamas , James Joseph Erdei , William Floyd Fobare , Dominick Anthony Quagliato , Schuyler Adam Antane , Albert Jean Robichaud
发明人: Michael Sotirios Malamas , James Joseph Erdei , William Floyd Fobare , Dominick Anthony Quagliato , Schuyler Adam Antane , Albert Jean Robichaud
IPC分类号: A61K31/4168 , C07D233/44
CPC分类号: C07D233/88 , C07D401/12 , C07D409/12
摘要: The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的2-氨基-5- [4-(二氟甲氧基)苯基] -5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶(BACE)和治疗β-淀粉样蛋白的方法 沉积物和神经原纤维缠结。
-
8.N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists 失效
标题翻译: N-(4-磺酰基芳基)环丙基胺2-羟乙基胺作为β-3肾上腺素能受体激动剂公开(公告)号:US06444685B1
公开(公告)日:2002-09-03
申请号:US09904114
申请日:2001-07-12
IPC分类号: C07D40112
CPC分类号: C07D401/12 , C07D211/58 , C07D401/14 , C07D417/14
摘要: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要翻译: 本发明提供具有其中R 1,R 2,R 3,R 4,W,X和Y如上所定义的结构的式I化合物或其药学上可接受的盐,其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。
-
公开(公告)号:US20100204245A1
公开(公告)日:2010-08-12
申请号:US12763612
申请日:2010-04-20
申请人: Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
发明人: Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
IPC分类号: A61K31/497 , C07D401/06 , A61K31/4439 , C07D401/12 , A61K31/444 , A61K31/506 , A61P25/28 , C12N5/071
CPC分类号: C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的氨基 - 吡啶化合物本发明还提供了其用于抑制和分泌(BACE)和治疗和淀粉样沉积物和神经原纤维缠结的方法。
-
10.Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase 失效
标题翻译: 用于抑制β-分泌酶的氨基-5- [4-(二氟甲氧基)苯基] -5-苯基咪唑啉酮化合物公开(公告)号:US07723368B2
公开(公告)日:2010-05-25
申请号:US12053086
申请日:2008-03-21
申请人: Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
发明人: Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
IPC分类号: A61K31/4166 , A61K31/4168 , C07D233/30
CPC分类号: C07D233/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供了用于抑制和分泌(BACE)和治疗和淀粉样沉积物和神经原纤维缠结的化合物和方法。
-
-
-
-
-
-
-
-
-