利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

34 条记录 (耗时 0.028 秒)

    Coated tablets
    1.
    发明授权
    Coated tablets 有权
    涂层片剂

    公开(公告)号：US08586094B2

    公开(公告)日：2013-11-19

    申请号：US10428007

    申请日：2003-05-02

    申请人： Michael Vachon ,  Mishra K. Awadesh ,  Robert A. Snow ,  Pol-Henri Guivarc'H

    发明人： Michael Vachon ,  Mishra K. Awadesh ,  Robert A. Snow ,  Pol-Henri Guivarc'H

    IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50

    CPC分类号： A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/148 ,  A61K9/16 ,  A61K9/1623 ,  A61K9/1629 ,  A61K9/167 ,  A61K9/1676 ,  A61K9/19 ,  A61K9/20 ,  A61K9/2077 ,  A61K9/282 ,  A61K9/284 ,  A61K9/2866 ,  A61K9/48 ,  A61K31/192 ,  A61K31/216 ,  A61K31/22 ,  A61K31/365 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/505 ,  A61K31/66 ,  A61K2300/00

    摘要： Disclosed is a pharmaceutically acceptable oral dosage form comprising fenofibrate, phospholipid, a buffer salt, a water-soluble bulking agent selected from maltodextrin, mannitol, and combinations thereof, a cellulosic additive, beads or crystals of a pharmaceutically acceptable water-soluble excipient support material, a polyvinylpyrrolidone or crospovidone, croscarmellose sodium, granular mannitol, sodium dodecyl sulfate, silicon dioxide, and a stearate, wherein the fenofibrate is in the form of microparticles, and wherein at least a portion of the phospholipid is coated on the surfaces of the fenofibrate microparticles, the phospholipid coated microparticles are embedded in a matrix comprising the water-soluble bulking agent, phospholipid that is not coated on the microparticles, the buffer salt and the cellulosic additive, and the matrix is coated on up to 100% of the surfaces of the beads or crystals of the excipient support material.

    摘要翻译： 公开了包含非诺贝特，磷脂，缓冲盐，选自麦芽糖糊精，甘露糖醇及其组合的水溶性填充剂的药学上可接受的口服剂型，纤维素添加剂，药学上可接受的水溶性赋形剂载体材料的珠粒或晶体 ，聚乙烯吡咯烷酮或交聚维酮，交联羧甲基纤维素钠，颗粒状甘露醇，十二烷基硫酸钠，二氧化硅和硬脂酸盐，其中非诺贝特为微粒形式，并且其中至少一部分磷脂被涂覆在非诺贝特 微粒，将包含磷脂的微粒嵌入包含水溶性填充剂的基质，未涂覆在微粒上的磷脂，缓冲盐和纤维素添加剂，并且将基质涂覆在至多100％的表面上 赋形剂载体材料的珠粒或晶体。

    Media milling
    7.
    发明授权
    Media milling 有权

    公开(公告)号：US06604698B2

    公开(公告)日：2003-08-12

    申请号：US09852054

    申请日：2001-05-10

    申请人： Frank H. Verhoff ,  Robert A. Snow ,  Gary W. Pace

    发明人： Frank H. Verhoff ,  Robert A. Snow ,  Gary W. Pace

    IPC分类号： B02C1716

    CPC分类号： A61K9/14 ,  A61K9/145 ,  B02C17/161 ,  Y10S977/775 ,  Y10S977/797 ,  Y10S977/90

    摘要： This invention describes a process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of (a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein the exit screen comprises openings of size S0; the large size media have a size distribution S1 of which all are larger than S0; the small size media have a size distribution S2 which are smaller than S0; the very small milled substrate particles have a size distribution S3 and are smaller than all of the small media; and the large size media and the small size media are essentially retained in the milling chamber.

    Cyclosporiine particles
    8.
    发明授权
    Cyclosporiine particles 有权

    公开(公告)号：US06465016B2

    公开(公告)日：2002-10-15

    申请号：US09750218

    申请日：2000-12-29

    申请人： Indu Parikh ,  Robert A. Snow

    发明人： Indu Parikh ,  Robert A. Snow

    IPC分类号： A61K914

    CPC分类号： B82Y5/00 ,  A61K9/145

    摘要： Pharmaceutical compositions containing solid cyclic oligopeptide cyclosporine microparticles are prepared by applying energy input to solid cyclic oligopeptide cyclosporine in the presence of phospholipid and one or more non-ionic, anionic or cationic second surface modifiers. The microparticles consist essentially of a solid cyclic oligopeptide cyclosporine core coated with a combination of phospholipid and at least one second surface modifier. The combination of phospholipid and second surface modifier(s) provide volume-weighted mean particle size values of solid cyclic oligopeptide cyclosporine particles that are about 50% smaller than cyclic oligopeptide cyclosporine particles produced in the presence of the phospholipid and without the presence of the second surface modifier(s) using the same energy input.

    MR imaging compositions and methods
    10.
    发明授权
    MR imaging compositions and methods 失效
    MR成像组合物和方法

    公开(公告)号：US5817292A

    公开(公告)日：1998-10-06

    申请号：US960746

    申请日：1992-10-14

    申请人： Robert A. Snow ,  David L. Ladd ,  John L. Toner

    发明人： Robert A. Snow ,  David L. Ladd ,  John L. Toner

    IPC分类号： A61K49/06 ,  A61K49/12 ,  A61K49/00

    CPC分类号： A61K49/128

    摘要： This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.

    摘要翻译： 本发明提供了可用于MR成像的组合物，其包含包含与聚（环氧烷）部分连接的螯合剂残基的单元的聚合物，所述聚合物具有与其相关的参与性金属离子。