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1.
公开(公告)号:US07056915B2
公开(公告)日:2006-06-06
申请号:US10422471
申请日:2003-04-24
申请人: Michel Jose Emmanuel , Eugene R. Hickey , Weimin Liu , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
发明人: Michel Jose Emmanuel , Eugene R. Hickey , Weimin Liu , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
IPC分类号: A61K31/535 , C07D265/12
CPC分类号: C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
摘要翻译: 公开了本文进一步定义的新颖的组织蛋白酶S,K,F,L和B可逆抑制化合物(I),(II),(Ia)和(Ib)。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法
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2.
公开(公告)号:US06420364B1
公开(公告)日:2002-07-16
申请号:US09655351
申请日:2000-09-08
申请人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
发明人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
IPC分类号: A61K31535
CPC分类号: C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
摘要翻译: 公开了本文进一步定义的新颖的组织蛋白酶S,K,F,L和B可逆抑制化合物(I),(II),(Ia)和(Ib)。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法。
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3.
公开(公告)号:US07279472B2
公开(公告)日:2007-10-09
申请号:US10937636
申请日:2004-09-09
申请人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
发明人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
IPC分类号: A61K31/535 , A61K31/497 , A61K31/40 , C07D413/02 , C07D401/12
CPC分类号: C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
摘要翻译: 公开了本文进一步定义的新颖的组织蛋白酶S,K,F,L和B可逆抑制化合物(I),(II),(Ia)和(Ib)。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法
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公开(公告)号:US06982272B2
公开(公告)日:2006-01-03
申请号:US10422473
申请日:2003-04-24
申请人: Michel Jose Emmanuel , Eugene R. Hickey , Weimin Liu , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
发明人: Michel Jose Emmanuel , Eugene R. Hickey , Weimin Liu , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
IPC分类号: A61K31/445 , C07D213/02 , C07D409/12
CPC分类号: C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
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5.
公开(公告)号:US07265132B2
公开(公告)日:2007-09-04
申请号:US10937533
申请日:2004-09-09
申请人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
发明人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
IPC分类号: A61K31/445 , C07D211/06 , C07D211/56
CPC分类号: C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要: Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
摘要翻译: 公开了本文进一步定义的组合蛋白酶S,K,F,L和B可逆抑制化合物(I),(II),(Ia)和(Ib)。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法
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6.Succinate derivative compounds useful as cysteine protease inhibitors 有权
标题翻译: 可用作半胱氨酸蛋白酶抑制剂的琥珀酸衍生物化合物公开(公告)号:US06313117B1
公开(公告)日:2001-11-06
申请号:US09627869
申请日:2000-07-28
申请人: Younes Bekkali , Rajashehar Betageri , Michel Jose Emmanuel , Eugene Richard Hickey , Weimin Liu , Usha R. Patel , Denice Mary Spero , David S. Thomson , Yancey David Ward , Erick Richard Roush Young , Sanxing Sun
发明人: Younes Bekkali , Rajashehar Betageri , Michel Jose Emmanuel , Eugene Richard Hickey , Weimin Liu , Usha R. Patel , Denice Mary Spero , David S. Thomson , Yancey David Ward , Erick Richard Roush Young , Sanxing Sun
IPC分类号: A61K315355
CPC分类号: C07D295/185 , C07B2200/07 , C07C255/31 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07D207/16 , C07D211/66 , C07D403/06 , C07D405/04 , C07D409/06
摘要: Disclosed are novel succinate derivative compounds of the formula(I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.
摘要翻译: 公开了式(I)/(Ia)的新型琥珀酸酯衍生物化合物:其中R1,R2,R3,R4,R5,R6,R7,X和A如本文所定义。 该化合物可用作半胱氨酸蛋白酶的抑制剂。 还公开了使用方法和制备这些化合物的方法。
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7.
公开(公告)号:US06756372B2
公开(公告)日:2004-06-29
申请号:US10001134
申请日:2001-11-02
申请人: Michel Jose Emmanuel , Weimin Liu , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward
发明人: Michel Jose Emmanuel , Weimin Liu , Denice Mary Spero , Sanxing Sun , David S. Thomson , Yancey David Ward
IPC分类号: A61K315355
CPC分类号: C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
摘要翻译: 公开了本文进一步定义的新颖的组织蛋白酶S,K,F,L和B可逆抑制化合物(I),(II),(Ia)和(Ib)。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法。
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公开(公告)号:US09073895B2
公开(公告)日:2015-07-07
申请号:US13325564
申请日:2011-12-14
申请人: Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi
发明人: Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi
IPC分类号: C07D213/72 , A61K31/345 , C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中A,B,C,R 1a,R 1b,R 2,R 3,R 4a和R 4b如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US20100240702A1
公开(公告)日:2010-09-23
申请号:US12596152
申请日:2008-05-15
申请人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号: A61K31/454 , C07D235/26 , C07D211/32 , A61K31/4166 , A61P9/12 , A61P9/10 , A61P13/12
CPC分类号: C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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公开(公告)号:US09150556B2
公开(公告)日:2015-10-06
申请号:US12596152
申请日:2008-05-15
申请人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号: C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
CPC分类号: C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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