公开(公告)号：US20240108781A1

公开(公告)日：2024-04-04

申请号：US18482688

申请日：2023-10-06

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Rob Greene ,  Clayton Harris

IPC: A61L24/06 ,  A61K49/04 ,  A61K49/12 ,  A61L24/00

CPC classification number: A61L24/06 ,  A61K49/0442 ,  A61K49/12 ,  A61L24/001 ,  A61L24/0015 ,  A61L2300/44 ,  A61L2400/06 ,  A61L2430/36

Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US11331340B2

公开(公告)日：2022-05-17

申请号：US16806936

申请日：2020-03-02

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61K9/00 ,  A61K31/78 ,  A61L24/00 ,  A61L24/04 ,  A61K47/32

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US10258716B2

公开(公告)日：2019-04-16

申请号：US15491864

申请日：2017-04-19

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Rob Greene ,  Clayton Harris

IPC: A61K49/04 ,  A61K49/12 ,  A61L24/04 ,  A61L24/06 ,  A61L24/00

Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US10194915B2

公开(公告)日：2019-02-05

申请号：US15272305

申请日：2016-09-21

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Terrance T. Tran

IPC: A61B17/00 ,  A61B17/12 ,  A61B90/00 ,  A61K49/04 ,  A61L24/00 ,  A61L24/04 ,  A61L27/16 ,  A61L27/18 ,  A61L27/56 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/18 ,  C08L39/06 ,  C08L71/02

Abstract: Described are devices for implantation comprising a hydrogel filament wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer, an ethylenically unsaturated monomer, and a visualization agent. Methods of making and using these devices are also described.

公开(公告)号：US20160243273A1

公开(公告)日：2016-08-25

申请号：US14736145

申请日：2015-06-10

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Rob Greene ,  Clayton Harris

IPC: A61L24/06 ,  A61K49/12 ,  A61L24/00 ,  A61K49/04

CPC classification number: A61L24/06 ,  A61K49/0442 ,  A61K49/12 ,  A61L24/001 ,  A61L24/0015 ,  A61L2300/44 ,  A61L2400/06 ,  A61L2430/36 ,  C08L33/08 ,  C08L33/26

Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

Abstract translation: 描述了包含生物相容性聚合物的聚合物组合物，其包括与可视化试剂和非生理pH溶液的生物可降解连接; 其中所述生物相容性聚合物可溶于非生理pH溶液中，并且在生理pH下不溶。 公开了形成溶液和聚合物的方法以及治疗用途的方法。

公开(公告)号：US20160243157A1

公开(公告)日：2016-08-25

申请号：US15142395

申请日：2016-04-29

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61K9/00

CPC classification number: A61K31/785 ,  A61K9/0024 ,  A61K31/78 ,  A61K47/32 ,  A61L24/0089 ,  A61L24/046 ,  A61L2430/36

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US20190151452A1

公开(公告)日：2019-05-23

申请号：US16250878

申请日：2019-01-17

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Clayton G. Harris ,  Michael J. Constant

IPC: A61K47/32 ,  A61K47/58 ,  A61L31/18 ,  A61L31/16 ,  A61L31/14 ,  A61K31/7068 ,  A61K9/00 ,  A61K49/04 ,  C07F15/00 ,  C07H19/06 ,  A61K31/787

Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.

公开(公告)号：US20190150932A1

公开(公告)日：2019-05-23

申请号：US16250880

申请日：2019-01-17

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Terrance Tran

IPC: A61B17/12 ,  A61L31/02 ,  A61L31/04 ,  A61L31/14 ,  A61L31/00 ,  A61L31/06

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

公开(公告)号：US10226258B2

公开(公告)日：2019-03-12

申请号：US15635046

申请日：2017-06-27

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Terrance Tran

IPC: A61B17/12 ,  A61L31/00 ,  A61L31/02 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  C08L71/02

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

公开(公告)号：US20170290593A1

公开(公告)日：2017-10-12

申请号：US15635046

申请日：2017-06-27

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Terrance Tran

IPC: A61B17/12 ,  A61L31/02 ,  A61L31/04 ,  A61L31/14 ,  A61L31/06

CPC classification number: A61B17/1219 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/12154 ,  A61B17/12168 ,  A61L31/00 ,  A61L31/022 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/145 ,  A61L31/146 ,  A61L2400/04 ,  C08L71/02

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.