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公开(公告)号：US11031221B2
公开(公告)日：2021-06-08
申请号：US15555758
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Emrys Jones , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Zoltan Takats
IPC: H01J49/00 , H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145 , G06F19/00
Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
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公开(公告)号：US10777399B2
公开(公告)日：2020-09-15
申请号：US15764791
申请日：2016-09-22
Applicant: Micromass UK Limited
Inventor： Steven Derek Pringle , Lajos Godorhazy , Daniel Simon , Daniel Szalay , Zoltan Takats , Tamas Karancsi
IPC: H01J49/04 , G01N33/483 , G01N21/31 , G01N21/65
Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.
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公开(公告)号：US11367606B2
公开(公告)日：2022-06-21
申请号：US16544636
申请日：2019-08-19
Applicant: Micromass UK Limited
Inventor： Zoltan Takats , Emrys Jones , James Ian Langridge , Michael Raymond Morris , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Keith Richardson , Phillip Robert Bennett , David Alan MacIntyre , Pamela Pruski
IPC: H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
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公开(公告)号：US11264223B2
公开(公告)日：2022-03-01
申请号：US16033447
申请日：2018-07-12
Applicant: Micromass UK Limited
Inventor： Zoltan Takats , Emrys Jones , James Ian Langridge , Michael Raymond Morris , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Keith Richardson , Phillip Robert Bennett , David Alan Macintyre , Pamela Pruski
IPC: H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
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公开(公告)号：US11133164B2
公开(公告)日：2021-09-28
申请号：US16778423
申请日：2020-01-31
Applicant: Micromass UK Limited
Inventor： Steven Derek Pringle , Lajos Godorhazy , Daniel Simon , Daniel Szalay , Zoltan Takats , Tamas Karancsi
IPC: H01J49/04 , G01N33/483 , G01N21/31 , G01N21/65
Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.
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Patent Agency Ranking
公开(公告)号：US20180286652A1
公开(公告)日：2018-10-04
申请号：US15764791
申请日：2016-09-22
Applicant: Micromass UK Limited
Inventor： Steven Derek Pringle , Lajos Godorhazy , Daniel Simon , Daniel Szalay , Zoltan Takats , Tamas Karancsi
IPC: H01J49/04 , G01N33/483 , G01N21/31 , G01N21/65
Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.
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公开(公告)号：US11342170B2
公开(公告)日：2022-05-24
申请号：US15555845
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Tamas Karancsi , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Steven Derek Pringle , Emrys Jones , Ian Trivett , Stephen O'Brien , Anthony Hesse , Matt Henderson , Alvin Chua , Zoltan Takats
IPC: A61B17/00 , H01J49/04 , A61B10/02 , A61B17/32 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B5/00 , G01N27/626 , G16H20/00 , G16H10/40 , G16H50/20 , A61B1/273 , A61B5/0507 , A61B10/00 , A61B18/04 , A61B18/18 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , H01J49/00 , A61B5/145 , A61B18/00
Abstract: An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.
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公开(公告)号：US11094519B2
公开(公告)日：2021-08-17
申请号：US16862039
申请日：2020-04-29
Applicant: Micromass UK Limited
Inventor： Tamas Karancsi , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Steven Derek Pringle , Emrys Jones , Ian Trivett , Stephen O'Brien , Anthony Hesse , Matt Henderson , Alvin Chua , Zoltan Takáts
IPC: H01J49/00 , H01J49/04 , A61B10/02 , A61B17/32 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B5/00 , G01N27/626 , G16H20/00 , G16H10/40 , G16H50/20 , A61B1/273 , A61B5/0507 , A61B10/00 , A61B18/04 , A61B18/18 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , A61B5/145 , A61B18/00
Abstract: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
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公开(公告)号：US10910206B2
公开(公告)日：2021-02-02
申请号：US16662881
申请日：2019-10-24
Applicant: Micromass UK Limited
Inventor： Tamas Karancsi , Lajos Godorhazy , Daniel Szalay , Zoltan Takats , Julia Balog , Steven Derek Pringle , Daniel Simon
IPC: H01J49/00 , H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/05 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/62 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H70/00 , G16H20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145 , G06F19/00
Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
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公开(公告)号：US10784096B2
公开(公告)日：2020-09-22
申请号：US15555758
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Emrys Jones , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Zoltan Takats
IPC: H01J49/00 , H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/05 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/62 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145 , G06F19/00
Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
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