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公开(公告)号：US09625463B2
公开(公告)日：2017-04-18
申请号：US14181023
申请日：2014-02-14
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC: B01L1/00 , C12M1/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , C12M1/26 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , G01N35/00 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783
CPC classification number: G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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2.发明申请AUTOMATED METHOD FOR STERILE PROCESSING OF CELLS BY CENTRIFUGATION AND COLUMN CHROMATOGRAPHY 审中-公开通过离心和色谱法进行细胞纯化处理的自动化方法
公开(公告)号：US20160216270A1
公开(公告)日：2016-07-28
申请号：US15003069
申请日：2016-01-21
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschafer , Martin Biehl , Eiad Kabaha , Jurgen Schulz
IPC: G01N33/58 , A61M1/36 , C12N5/0783 , C12N5/077 , G01N35/00 , C12N5/0789
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
Abstract translation: 本发明涉及一种系统，包括：a）样品处理单元，包括输入端口和耦合到具有至少一个样品室的旋转容器的输出端口，所述样品处理单元配置为样品提供第一处理步骤或 使容器旋转以对沉积在室中的样品施加离心力，并分离沉积样品的至少第一组分和第二组分; 以及b）样品分离单元，其耦合到所述样品处理单元的输出端口，所述细胞分离单元包括分离柱保持器（42），泵（64）和多个阀（1-11），其被配置为至少部分地 控制流体流过流体回路和位于所述保持器中的分离柱（40），所述分离柱构造成分离流过所述塔的样品的标记和未标记组分。
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公开(公告)号：US20140212961A1
公开(公告)日：2014-07-31
申请号：US14201744
申请日：2014-03-07
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschafer , Martin Biehl , Eiad Kabaha , Jürgen Schulz
IPC: C12M1/26
CPC classification number: G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
Abstract: The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.
Abstract translation: 本发明涉及一种用于将样品分离成至少两个组分的离心机，包括用于接收要离心的样品的室。 根据本发明，离心机还包括用于控制样品分离进度位于腔室的装置。
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4.发明授权
公开(公告)号：US10705090B2
公开(公告)日：2020-07-07
申请号：US15003069
申请日：2016-01-21
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschafer , Martin Biehl , Eiad Kabaha , Jurgen Schulz
IPC: G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36 , B01L3/00
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US10119970B2
公开(公告)日：2018-11-06
申请号：US15395215
申请日：2016-12-30
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC: C12M1/00 , C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , C12M1/26 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , G01N35/00 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , C12M1/36
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US20200141942A1
公开(公告)日：2020-05-07
申请号：US16675072
申请日：2019-11-05
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC: G01N33/58 , C12N5/00 , C12M1/36 , C12M1/00 , C12N5/0783 , A61M1/36 , C12N5/077 , C12N5/0789 , B01D15/38 , B04B7/08 , B04B1/12 , B04B5/10 , B04B5/04 , B04B5/00 , B01D21/26 , C12M1/26 , G01N35/00 , A61M1/02 , B03C1/034 , B03C1/033 , B03C1/027 , B03C1/00 , B03C1/032 , B04B13/00 , B03C1/28
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US20180010087A1
公开(公告)日：2018-01-11
申请号：US15706517
申请日：2017-09-15
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US09714945B2
公开(公告)日：2017-07-25
申请号：US14201744
申请日：2014-03-07
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Elmar Niklas Neuschäfer , Martin Biehl , Eiad Kabaha , Jürgen Schulz
IPC: G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , G01N35/00 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02
CPC classification number: G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
Abstract: The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.
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公开(公告)号：US10705091B2
公开(公告)日：2020-07-07
申请号：US16675072
申请日：2019-11-05
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC: B01L3/00 , C12M3/00 , G01N33/58 , C12M1/36 , C12M1/00 , C12N5/0783 , A61M1/36 , C12N5/077 , C12N5/0789 , B01D15/38 , B04B7/08 , B04B1/12 , B04B5/10 , B04B5/04 , B04B5/00 , B01D21/26 , C12M1/26 , G01N35/00 , A61M1/02 , B03C1/034 , B03C1/033 , B03C1/027 , B03C1/00 , B03C1/032 , B04B13/00 , B03C1/28 , C12N5/00
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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10.发明申请
公开(公告)号：US20170107480A1
公开(公告)日：2017-04-20
申请号：US15395215
申请日：2016-12-30
Applicant: Miltenyi Biotec GmbH
Inventor： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
CPC classification number: G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
