公开(公告)号：US20130309212A1

公开(公告)日：2013-11-21

申请号：US13982965

申请日：2012-01-17

申请人： Ming Zhang ,  Fang Wang ,  Huiyuan Guo ,  Jun Zhu ,  Lu Jiang

发明人： Ming Zhang ,  Fang Wang ,  Huiyuan Guo ,  Jun Zhu ,  Lu Jiang

IPC分类号： A61K35/74

CPC分类号： A61K35/74 ,  A23L33/135 ,  A23Y2220/79 ,  A61K35/747 ,  C12N1/20 ,  C12R1/225

摘要： Provided is a Lactobacillus salivarius belonging to Lactobacillus salivarius subsp. Salivarius and deposited in China General Microbiological Culture Collection Center with an accession number CGMCC No: 3606. Further provided is a method for preparing a metabolite of the Lactobacillus salivarius, wherein the Lactobacillus salivarius is as described above. Further provided is a composition, comprising viable strains of the Lactobacillus salivarius and/or the metabolite of the Lactobacillus salivarius prepared as described above. Further provided is a use of the composition in preparation of drugs for prevention and/or treatment of cancers and a method for treating and/or preventing cancers. The viable strains of Lactobacillus salivarius and the metabolite of Lactobacillus salivarius provided in the present invention can both remove the genotoxicity of 4-NQQ in vivo, thus exerting an effect of effectively preventing and/or treating cancers.

摘要翻译： 本发明提供一种属于唾液乳杆菌的唾液乳杆菌属（Lactobacillus salivarius）。 唾液疣并存入中国通用微生物培养物收集中心，登录号CGMCC No：3606.进一步提供了一种制备唾液乳杆菌代谢物的方法，其中唾液乳杆菌如上所述。 进一步提供了一种组合物，其包含如上所述制备的唾液乳杆菌和/或唾液乳杆菌的代谢物的活菌株。 还提供了该组合物在制备用于预防和/或治疗癌症的药物中的用途以及用于治疗和/或预防癌症的方法。 本发明提供的唾液乳杆菌和唾液乳杆菌的代谢物的活菌可以在体内消除4-NQQ的基因毒性，从而发挥有效预防和/或治疗癌症的作用。

公开(公告)号：US20070219231A1

公开(公告)日：2007-09-20

申请号：US11578828

申请日：2005-04-13

申请人： Huiyuan Guo ,  Jiuyu Liu

发明人： Huiyuan Guo ,  Jiuyu Liu

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D417/02 ,  C07D471/04

摘要： This invention discloses novel quinolonecarboxylic acid derivatives, pharmaceutically acceptable salts or hydrates thereof, and their preparation methods and medical uses. The compounds in this invention show potent antibacterial activity against broad-spectrum pathogenic bacteria, with favorable pharmacokinetics and very low toxicity. The quinolinecarboxylic acid derivatives, which possess a hydrogen atom or an amino group at C-5 position, cis-substituted optical or racemic 2,8-diazo-dicyclo[4,3,0]nonanyl at C-7 position, and difluoromethoxyl at C-8 position of quinolone core, have superior activity against gram-positive bacteria and broad spectrum antibacterial activity compared with the known quinolones.

摘要翻译： 本发明公开了新型喹诺酮羧酸衍生物，其药学上可接受的盐或水合物及其制备方法和医疗用途。 本发明化合物对广谱病原菌显示出有效的抗菌活性，具有良好的药代动力学和非常低的毒性。 在C-5位具有氢原子或氨基的喹啉羧酸衍生物，C-7位的顺式取代的光学或外消旋的2,8-重氮二环[4,3,0]壬酰基和二氟甲氧基 喹诺酮核心的C-8位，与已知的喹诺酮相比，具有优异的革兰氏阳性细菌活性和广谱抗菌活性。

公开(公告)号：US20170052123A1

公开(公告)日：2017-02-23

申请号：US15239150

申请日：2016-08-17

申请人： Lili He ,  Baoshan Xing ,  Huiyuan Guo

发明人： Lili He ,  Baoshan Xing ,  Huiyuan Guo

IPC分类号： G01N21/77 ,  G01N33/20 ,  G01N21/65

CPC分类号： G01N33/20 ,  G01N1/4055 ,  G01N15/06 ,  G01N21/658 ,  G01N2001/4061 ,  G01N2015/0038 ,  G01N2015/0693

摘要： Systems and methods are provided herein for the extraction, detection and measurement of MNPs in complex matrices in particular, the method includes mixing a solution including a predetermined organic substance with a matrix including the metal nanoparticles, the predetermined organic substance adapted to bind to the metal nanoparticles, to facilitate extraction by an organic solvent and to provide a distinct SERS signal, the mixing resulting in a suspension, adding a solution of a predetermined organic extraction solvent to the suspension, extracting and separating the metal nanoparticles; the metal nanoparticles, after extraction, functionalized by binding with the predetermined organic substance, and extracting and separating the metal nanoparticles; the metal nanoparticles, after extraction, functionalized by binding with the predetermined organic substance; and performing SERS imaging on the functionalized metal nanoparticles in order to detect metals nanoparticles.

摘要翻译： 本文提供了用于在复杂基质中提取，检测和测量MNP的系统和方法，所述方法包括将包含预定有机物质的溶液与包含金属纳米颗粒的基质混合，适于结合金属的预定有机物质 纳米颗粒，以便于通过有机溶剂萃取并提供不同的SERS信号，混合得到悬浮液，将预定的有机萃取溶剂的溶液加入到悬浮液中，萃取和分离金属纳米颗粒; 所述金属纳米粒子在萃取后通过与所述预定有机物质结合而官能化，并提取和分离所述金属纳米粒子; 萃取后的金属纳米粒子与预定的有机物质结合而官能化; 并对官能化金属纳米粒子进行SERS成像以检测金属纳米粒子。

公开(公告)号：US07759362B2

公开(公告)日：2010-07-20

申请号：US11578828

申请日：2005-04-13

申请人： Huiyuan Guo ,  Jiuyu Liu

发明人： Huiyuan Guo ,  Jiuyu Liu

IPC分类号： C07D215/38 ,  A61K31/48

CPC分类号： C07D417/02 ,  C07D471/04

摘要： This invention discloses novel quinolonecarboxylic acid derivatives, pharmaceutically acceptable salts or hydrates thereof, and their preparation methods and medical uses. The compounds in this invention show potent antibacterial activity against broad-spectrum pathogenic bacteria, with favorable pharmacokinetics and very low toxicity. The quinolinecarboxylic acid derivatives, which possess a hydrogen atom or an amino group at C-5 position, cis-substituted optical or racemic 2,8-diazo-dicyclo[4,3,0]nonanyl at C-7 position, and difluoromethoxyl at C-8 position of quinolone core, have superior activity against gram-positive bacteria and broad spectrum antibacterial activity compared with the known quinolones.

摘要翻译： 本发明公开了新型喹诺酮羧酸衍生物，其药学上可接受的盐或水合物及其制备方法和医疗用途。 本发明化合物对广谱病原菌显示出有效的抗菌活性，具有良好的药代动力学和非常低的毒性。 在C-5位具有氢原子或氨基的喹啉羧酸衍生物，C-7位的顺式取代的光学或外消旋的2,8-重氮二环[4,3,0]壬酰基和二氟甲氧基 喹诺酮核心的C-8位，与已知的喹诺酮相比，具有优异的革兰氏阳性细菌活性和广谱抗菌活性。