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公开(公告)号：US20110150966A1
公开(公告)日：2011-06-23
申请号：US13037154
申请日：2011-02-28
申请人： Mingfei Chen , Peiwen Cheng , Ya Guo , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Ya Guo , Kishore Udipi
IPC分类号： A61K47/34 , A61F2/00 , A61K39/395 , A61K31/436 , A61K31/565
CPC分类号： A61L31/148 , A61F2210/0004 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/402 , A61L2300/414 , A61L2300/432 , C08G63/08 , C08G63/823 , C09D167/04 , C08L67/04
摘要： Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer is formed from ring opening of γ-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of ε-caprolactone, 4-tert-butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers.
摘要翻译： 本文公开了其上具有可控释放的可生物降解的聚合物涂层的可植入医疗装置，其中所述聚合物由γ-丁内酯的开环和至少一种选自三亚甲基碳酸酯，丙交酯，聚乙二醇，乙交酯的另外的单体形成，所形成的单体 由ε-己内酯，4-叔丁基己内酯和N-乙酰基己内酯的开环及其组合，以及可从生物可降解聚合物中释放的至少一种药物。 还公开了可生物降解聚合物的可植入医疗装置形式和形成聚合物的方法。
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公开(公告)号：US07811600B2
公开(公告)日：2010-10-12
申请号：US11683885
申请日：2007-03-08
申请人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
发明人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
CPC分类号： A61L27/14 , A61L17/145 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10
摘要： Disclosed are implantable medical devices comprising nitric oxide (NO) donating polymers comprising polymer backbones having at least one cyclic amine disposed thereon. Methods are further disclosed for providing nitric oxide-donating polymers.
摘要翻译： 公开了包含一氧化氮（NO）供体聚合物的植入式医疗装置，其包含其上布置有至少一个环状胺的聚合物主链。 进一步公开了提供一氧化氮供体聚合物的方法。
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3.发明申请Biocompatible controlled release coatings for medical devices and related methods 有权用于医疗器械和相关方法的生物相容性控释涂层公开(公告)号：US20050084515A1
公开(公告)日：2005-04-21
申请号：US11005463
申请日：2004-12-06
申请人： Kishore Udipi , Peiwen Cheng , Mingfei Chen , Su-Ping Lyu
发明人： Kishore Udipi , Peiwen Cheng , Mingfei Chen , Su-Ping Lyu
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/602
摘要： Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.
摘要翻译： 公开了用于医疗装置的生物相容性涂层。 具体地，公开了设计用于在体内控制生物活性剂从医疗装置释放的聚合物涂层，其中聚合物和药物的溶解度参数与控制洗脱速率曲线紧密匹配。 本申请还公开了提供具有控制释放涂层的血管支架和用于制备这些涂层的相关方法。
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公开(公告)号：US08709465B2
公开(公告)日：2014-04-29
申请号：US12422425
申请日：2009-04-13
申请人： Mingfei Chen , David Shumaker , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , David Shumaker , Peiwen Cheng , Kishore Udipi
IPC分类号： A61F2/02 , A61F2/04 , A61K31/436 , C08F130/02
CPC分类号： A61K31/80 , A61K47/58 , A61K47/6957
摘要： The present disclosure in a broad aspect provides for diazeniumdiolated phosphorylcholine polymers and associated methods for achieving nitric oxide release. The present polymers have superior biocompatibility and are useful for coating or fabricating medical devices such as a vascular stent.
摘要翻译： 本发明在广泛的方面提供二氮烯二烯基磷酸胆碱聚合物和用于实现一氧化氮释放的相关方法。 本发明的聚合物具有优异的生物相容性，并且可用于涂覆或制造诸如血管支架的医疗装置。
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5.发明授权Terpolymers for controlled release of bioactive agents from implantable medical devices 有权用于从可植入医疗器械控制释放生物活性剂的三元共聚物公开(公告)号：US07815927B2
公开(公告)日：2010-10-19
申请号：US11683836
申请日：2007-03-08
申请人： Peiwen Cheng , Kishore Udipi , Mingfei Chen
发明人： Peiwen Cheng , Kishore Udipi , Mingfei Chen
IPC分类号： A61L27/00 , A61F2/00 , A61K31/56 , A61K31/7105 , A61K33/00 , A61K39/395
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/256 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/432 , C08L33/08 , C08L39/06
摘要： Disclosed herein are implantable medical devices comprising controlled release terpolymers and at least one drug releasable from said terpolymers coating. The terpolymers of the present invention are comprised of acrylate and/or vinyl monomers.
摘要翻译： 本文公开了包含控制释放三聚物和至少一种可从所述三元共聚物涂层释放的药物的可植入医疗装置。 本发明的三元共聚物由丙烯酸酯和/或乙烯基单体组成。
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6.发明申请Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers 审中-公开可生物降解碳二氮烯二氧化钛一氧化氮捐赠聚合物公开(公告)号：US20090232863A1
公开(公告)日：2009-09-17
申请号：US12049618
申请日：2008-03-17
申请人： Peiwen Cheng , Kishore Udipi , Mingfei Chen
发明人： Peiwen Cheng , Kishore Udipi , Mingfei Chen
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/604
摘要： Disclosed herein are implantable medical devices coated with or comprising bioabsorbable carbon-based nitric oxide-donating polymers that upon exposure to physiological environments donate nitric oxide (NO).
摘要翻译： 这里公开的可植入医疗器械被涂覆或包含生物可吸收的碳基一氧化氮供体聚合物，其在暴露于生理环境中时，可以提供一氧化氮（NO）。
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7.发明申请Terpolymers for Controlled Release of Bioactive Agents From Implantable Medical Devices 有权用于可植入医疗器械控制释放生物活性剂的三元共聚物公开(公告)号：US20080220046A1
公开(公告)日：2008-09-11
申请号：US11683836
申请日：2007-03-08
申请人： Peiwen Cheng , Kishore Udipi , Mingfei Chen
发明人： Peiwen Cheng , Kishore Udipi , Mingfei Chen
IPC分类号： A61L27/00 , A61F2/00 , A61K31/56 , A61K31/7105 , A61K33/00 , A61K39/395
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/256 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/432 , C08L33/08 , C08L39/06
摘要： Disclosed herein are implantable medical devices comprising controlled release terpolymers and at least one drug releasable from said terpolymers coating. The terpolymers of the present invention are comprised of acrylate and/or vinyl monomers.
摘要翻译： 本文公开了包含控制释放三聚物和至少一种可从所述三元共聚物涂层释放的药物的可植入医疗装置。 本发明的三元共聚物由丙烯酸酯和/或乙烯基单体组成。
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8.发明申请Biodegradable Modified Caprolactone Polymers for Fabricating and Coating Medical Devices 审中-公开用于制造和涂覆医疗器械的可生物降解的改性己内酯聚合物公开(公告)号：US20070264307A1
公开(公告)日：2007-11-15
申请号：US11383262
申请日：2006-05-15
申请人： Mingfei Chen , Peiwen Cheng , Ya Guo , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Ya Guo , Kishore Udipi
IPC分类号： A61F2/06
CPC分类号： C08G63/664 , A61L27/34 , A61L27/58 , A61L29/085 , A61L29/148 , A61L31/10 , A61L31/148 , C08G63/08 , C09D167/04 , C08L67/04
摘要： Disclosed herein are biodegradable modified caprolactone polymers for coating and forming medical devices. The properties of the polymers are fine tuned for optimal performance depending on the medical purpose. Moreover, the polymers are suitable for the controlled in situ release of drugs at the treatment site.
摘要翻译： 本文公开了用于涂覆和形成医疗装置的可生物降解的改性己内酯聚合物。 根据医疗目的，聚合物的性质被微调以获得最佳性能。 此外，聚合物适合于在治疗部位的药物的受控原位释放。
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9.发明申请公开(公告)号：US20070264225A1
公开(公告)日：2007-11-15
申请号：US11383257
申请日：2006-05-15
申请人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
发明人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
IPC分类号： A61K31/785 , A61F2/02 , C08F265/02
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , C08L33/10 , C08L33/14
摘要： Disclosed are hindered amine nitric oxide (NO) donating polymers for coating implantable medical devices. The polymers include sterically hindered secondary amines that do not react with monomer carbonyls or electrophilic alkenes, facilitating the synthesis of the NO donating polymers. The polymers are coated on implantable medical devices, providing anti-restenosis therapy by the release of NO at the implantation site.
摘要翻译： 公开了用于涂覆可植入医疗装置的受阻胺一氧化氮（NO）供体聚合物。 聚合物包括不与单体羰基或亲电烯烃反应的空间位阻仲胺，促进NO供体聚合物的合成。 聚合物涂覆在可植入的医疗装置上，通过植入部位的NO释放提供抗再狭窄治疗。
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10.发明授权Biocompatible controlled release coatings for medical devices and related methods 有权用于医疗器械和相关方法的生物相容性控释涂层公开(公告)号：US08088404B2
公开(公告)日：2012-01-03
申请号：US11005463
申请日：2004-12-06
申请人： Kishore Udipi , Peiwen Cheng , Mingfei Chen , Su-Ping Lyu
发明人： Kishore Udipi , Peiwen Cheng , Mingfei Chen , Su-Ping Lyu
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/602
摘要： Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.
摘要翻译： 公开了用于医疗装置的生物相容性涂层。 具体地，公开了设计用于在体内控制生物活性剂从医疗装置释放的聚合物涂层，其中聚合物和药物的溶解度参数与控制洗脱速率曲线紧密匹配。 本申请还公开了提供具有控制释放涂层的血管支架和用于制备这些涂层的相关方法。
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