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公开(公告)号：US6157030A
公开(公告)日：2000-12-05
申请号：US143398
申请日：1998-08-28
申请人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
发明人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
IPC分类号： H01J49/42
CPC分类号： H01J49/424
摘要： Disclosed is an ion trap mass spectrometer improved to obtain a high sensitivity without the lowering of resolution. By fitting a mesh electrode to an aperture (an ion sampling aperture or an ion extracting aperture) made in endcap electrodes constituting an ion trap mass analysis region, a radio frequency electric field in the mass analysis region is not disturbed even if the diameter of the aperture is set to a large value to heighten ion transmission efficiency. By fitting a shield electrode for preventing collision of ions with an insulated ring constituting an outer wall of the mass analysis region, charging up of the insulated ring is prevented to improve stability of detection signals. Furthermore, by arranging a shield member for shielding stray charged particles detouring through the circumference of the mass analysis region to approach an ion detector, generation of noises based on these stray charged particles is prevented.
摘要翻译： 公开了一种改进的离子阱质谱仪，可以在不降低分辨率的情况下获得高灵敏度。 通过将网状电极装配到构成离子阱质量分析区域的端盖电极中的孔（离子取样孔或离子提取孔）上，即使直径为 孔径被设定为大的值以提高离子传输效率。 通过安装用于防止离子与构成质量分析区域的外壁的绝缘环碰撞的屏蔽电极，防止了绝缘环的充电以提高检测信号的稳定性。 此外，通过设置用于屏蔽通过质量分析区域的圆周去除杂散带电粒子的屏蔽构件以接近离子检测器，防止了基于这些杂散带电粒子的噪声的产生。
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公开(公告)号：US5663560A
公开(公告)日：1997-09-02
申请号：US555192
申请日：1995-11-08
CPC分类号： H01J49/044 , H01J49/061
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译： 将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为 大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。
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3.发明授权Method and apparatus for ionizing a sample under atmospheric pressure and selectively introducing ions into a mass analysis region 失效用于在大气压下电离样品并选择性地将离子引入质量分析区域的方法和装置
公开(公告)号：US6005245A
公开(公告)日：1999-12-21
申请号：US919785
申请日：1997-08-29
CPC分类号： H01J49/061 , H01J49/044
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译： 将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为 大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。
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公开(公告)号：US06180941B2
公开(公告)日：2001-01-30
申请号：US09447578
申请日：1999-11-23
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分析分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域，以及离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置的电极之间 其中所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。
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公开(公告)号：US5969351A
公开(公告)日：1999-10-19
申请号：US796548
申请日：1997-02-06
CPC分类号： H01J49/168 , H01J49/0404 , H01J49/049 , G01N30/726
摘要： A semi-micro liquid chromatograph/mass spectrometer apparatus has an ion source. The space from the end portion of a flow passage of a liquid chromatograph shell to a vaporization portion is closed so as to prevent the inflow of a gas from outside the ion source into the space. Further, the nebulization and vaporization portions are joined together and heated by a common heater. Dilution of a sample to be analyzed is prevented, and high sensitivity detection becomes possible in a low velocity liquid chromatograph/mass spectrometer.
摘要翻译： 半微量液相色谱仪/质谱仪装置具有离子源。 从液相色谱仪壳体的流路端部到气化部分的空间被封闭，以防止从离子源外部的气体流入空间。 此外，将雾化和蒸发部分接合在一起并通过公共加热器加热。 防止要分析的样品的稀释，并且可以在低速液相色谱仪/质谱仪中进行高灵敏度检测。
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6.发明授权Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 失效用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US5898175A
公开(公告)日：1999-04-27
申请号：US708415
申请日：1996-09-05
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer employing an ion source includes a capillary for spraying therethrough liquid into the atmospheres and an orifice through which a portion in the vicinity of a tip of the capillary is inserted, the orifice being designed in such a way that gases are caused to flow up to the tip of the capillary along a peripheral wall face of the capillary. The flow rate of gas in the vicinity of the tip of the capillary is about the sonic velocity, and a voltage is applied across the liquid flowing through the capillary and the orifice or an electrode arranged in the vicinity of the tip of the capillary.
摘要翻译： 使用离子源的质谱仪包括用于将液体喷射到气氛中的毛细管和插入毛细管的尖端附近的部分的孔，孔被设计成使气体流动 直到毛细管的尖端沿着毛细管的周壁面。 毛细管尖端附近的气体的流速大约是声速，并且在流过毛细管的液体和布置在毛细管尖端附近的孔或电极之间施加电压。
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公开(公告)号：US06586730B1
公开(公告)日：2003-07-01
申请号：US09505428
申请日：2000-02-16
申请人： Seiji Kamimura , Isamu Takekoshi , Yasushi Terui , Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi
发明人： Seiji Kamimura , Isamu Takekoshi , Yasushi Terui , Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi
IPC分类号： H01J4900
CPC分类号： H01J49/282 , H01J49/04 , H01J49/42
摘要： A compact, easy-to-use device is provided which takes in a sample over a shorter distance, the sample introducing time is shortened, and contamination is prevented when the sample is introduced. A burner for generating a plasma, a deflecting portion provided with parallel electrodes for deflecting ions, and an analyzer room for performing mass separation of the deflected ions, these being disposed in a plane in the horizontal direction, and a sample setting portion for setting a sample, a peristaltic pump for aspirating the sample and the burner for introducing and burning the aspirated sample are disposed in a plane in the vertical direction relative to the aforesaid plane. The sample is supplied to the burner from below, and the ions generated by the plasma are made to flow on a horizontal plane.
摘要翻译： 提供了一种紧凑，易于使用的装置，其在较短距离内吸收样品，缩短了样品引入时间，并且在引入样品时防止污染。 用于产生等离子体的燃烧器，设置有用于偏转离子的平行电极的偏转部分和用于进行偏转离子的质量分离的分析器室，这些离子被设置在水平方向的平面中;以及样品设定部， 样品，抽吸样品的蠕动泵和用于引入和燃烧吸气样品的燃烧器相对于上述平面设置在垂直方向上的平面中。 将样品从下方供应到燃烧器，并且使由等离子体产生的离子在水平面上流动。
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公开(公告)号：US06541769B1
公开(公告)日：2003-04-01
申请号：US09660359
申请日：2000-09-12
IPC分类号： B01D5944
CPC分类号： H01J49/424 , H01J49/061
摘要： An ion-deflecting device is located between a mass spectrometer and a detector, and undesired signal sources are prevented from reaching the detector during the ion-trapping period by switching the voltage applied to the detector between the ion-trapping period and the mass-analyzing period. A first voltage is applied to the detector during an ion-trapping period while a second voltage is applied to the detector during a mass-analyzing period. An ion-deflecting device deflects ions such that they do not reach the detector during an ion-trapping period while they do reach the detector during a mass-analyzing period. This way, the life of the detector is increased.
摘要翻译： 离子偏转装置位于质谱仪和检测器之间，并且在离子捕获期间通过切换在离子捕获期和质量分析之间施加到检测器的电压来防止不期望的信号源到达检测器 期。 在离子捕获期间将第一电压施加到检测器，同时在质量分析期间将第二电压施加到检测器。 离子偏转装置使离子偏转，使得它们在离子捕获期间不会在质量分析期间到达检测器时到达检测器。 这样，检测器的寿命就会增加。
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公开(公告)号：US06423965B1
公开(公告)日：2002-07-23
申请号：US09378767
申请日：1999-08-23
IPC分类号： H01J4900
CPC分类号： H01J49/04
摘要： Plasma ion source mass spectrometers or liquid chromatograph/mass spectrometers are provided: wherein photon noises and matrix molecule ions produced by the ion source are decreased, the decrease of the quantity of signal is suppressed, and the apparatus maintenance is improved. The photon noises are decreased with a shielding plate and a 90 degrees deflector. The maintainability in cleaning is improved by a combination of a leading electrode, the shielding plate having a small hole, and a gate valve. The decrease in the quantity of signal is suppressed with the leading electrode, and a double cylindrical type static lens. Position adjustment of the leading electrode is performed with a flat plate having plural holes. Using an ion trap mass analyzer, matrix molecule ions are eliminated by applying a resonance voltage between its end cap electrodes. Decrease in the quantity of signals, which has been a problem, can be prevented, and a high transmission can be realized with a preferable reproducibility against disturbance of an electric field caused by ion lens and the like. A detectable limit of atomic ions of the sample can be improved by eliminating the matrix molecule ions.
摘要翻译： 提供了等离子体离子源质谱仪或液相色谱仪/质谱仪：其中由离子源产生的光子噪声和基质分子离子减少，抑制了信号量的减少，从而改善了设备的维护。 光子噪声随屏蔽板和90度偏转器而减小。 通过前导电极，具有小孔的屏蔽板和闸阀的组合来提高清洁的可维护性。 用前导电极和双圆柱形静电透镜抑制信号量的减少。 引导电极的位置调整用具有多个孔的平板进行。 使用离子阱质量分析仪，通过在其端盖电极之间施加谐振电压来消除基质分子离子。 可以防止已经存在问题的信号量的减少，并且以离子透镜等引起的电场干扰的优选再现性可以实现高透射率。 可以通过消除基质分子离子来改善样品的原子离子的可检测极限。
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公开(公告)号：US5825027A
公开(公告)日：1998-10-20
申请号：US831486
申请日：1997-03-31
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
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