2-cyanopiperazine and method of producing the same
    3.
    发明授权
    2-cyanopiperazine and method of producing the same 失效
    2-氰基哌嗪及其制备方法

    公开(公告)号:US5698697A

    公开(公告)日:1997-12-16

    申请号:US683370

    申请日:1996-07-18

    IPC分类号: C07D241/04

    CPC分类号: C07D241/04

    摘要: 2-Cyanopiperazine represented by the following formula (1): ##STR1## or a salt thereof. The 2-cyanopiperazine can be produced by reacting a 2-halogenoacrylonitrile with ethylenediamine or by reacting a 2,3-dihalogenopropionitrile with ethylenediamine. The 2-cyanopiperazine is useful as an intermediate for medicaments, agricultural chemicals, etc., and optically active N-tert-butyl-2-piperazine carboxamide, which is useful as an intermediate in preparation of the HIV protease inhibitor indinavir, can be easily produced using the 2-cyanopiperazine.

    摘要翻译: 由下式(1)表示的2-氰基哌嗪:其中(1)或其盐。 2-氰基哌嗪可以通过使2-卤代丙烯腈与乙二胺反应或通过使2,3-二卤代丙腈与乙二胺反应来制备。 2-氰基哌嗪可用作药物,农药等的中间体,可用于制备HIV蛋白酶抑制剂茚地那韦的中间体的光学活性N-叔丁基-2-哌嗪甲酰胺可以容易地 使用2-氰基哌嗪生产。

    Process for producing aromatic carboxylic acid
    4.
    发明授权
    Process for producing aromatic carboxylic acid 失效
    芳香族羧酸的制造方法

    公开(公告)号:US5760288A

    公开(公告)日:1998-06-02

    申请号:US804691

    申请日:1997-02-25

    IPC分类号: C07C51/265 C07C51/16

    CPC分类号: C07C51/265

    摘要: Provided is a process for producing an aromatic carboxylic acid by oxidizing an aromatic compound having an alkyl group or a partially-oxidized alkyl group with a molecular-oxygen-containing gas in an aqueous medium, characterized in that a compound in which a transition metal is incorporated into a heteropoly-acid skeleton having a deficient structural moiety is used as a catalyst. In accordance with the present invention, the aromatic carboxylic acid can be produced efficiently at low costs.

    摘要翻译: 本发明提供一种通过在水性介质中将含有分子氧的气体氧化具有烷基或部分氧化的烷基的芳香族化合物来制造芳香族羧酸的方法,其特征在于,过渡金属为 掺入具有缺陷结构部分的杂多酸骨架中用作催化剂。 根据本发明,可以低成本有效地制备芳族羧酸。