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公开(公告)号:US5614649A
公开(公告)日:1997-03-25
申请号:US552794
申请日:1995-11-03
IPC分类号: A61K31/18 , A61K31/216 , A61K31/22 , A61K31/275 , A61K31/277 , A61K31/353 , A61K31/4035 , A61K31/69 , A61K38/00 , A61K38/55 , A61K45/00 , A61P19/00 , A61P21/00 , A61P43/00 , C07C279/14 , C07C279/34 , C07C279/36 , C07C311/01 , C07C311/06 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/06 , C07C337/08 , C07D209/48 , C07D311/70 , C07F5/02 , C07K5/02 , C07K5/023 , C07K5/072 , C07C231/00 , C07D225/00
CPC分类号: C07D209/48 , A61K31/18 , A61K31/216 , A61K31/22 , A61K31/277 , A61K31/353 , A61K31/4035 , C07C279/36 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/08 , C07D311/70 , C07F5/025 , C07K5/0207 , C07K5/06095 , A61K38/00 , C07C2101/08
摘要: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
摘要翻译: 本文公开了由以下通式表示的多分析蛋白酶的抑制剂:本文公开了组成成分和优选的构成成员。 制备和使用所公开的化合物的方法也在本文中阐述。
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公开(公告)号:US5830870A
公开(公告)日:1998-11-03
申请号:US760638
申请日:1996-12-04
IPC分类号: A61K31/18 , A61K31/216 , A61K31/22 , A61K31/275 , A61K31/277 , A61K31/353 , A61K31/4035 , A61K31/69 , A61K38/00 , A61K38/55 , A61K45/00 , A61P19/00 , A61P21/00 , A61P43/00 , C07C279/14 , C07C279/34 , C07C279/36 , C07C311/01 , C07C311/06 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/06 , C07C337/08 , C07D209/48 , C07D311/70 , C07F5/02 , C07K5/02 , C07K5/023 , C07K5/072 , C07C231/00 , C07C235/00 , C07C255/00
CPC分类号: C07D209/48 , A61K31/18 , A61K31/216 , A61K31/22 , A61K31/277 , A61K31/353 , A61K31/4035 , C07C279/36 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/08 , C07D311/70 , C07F5/025 , C07K5/0207 , C07K5/06095 , A61K38/00 , C07C2101/08
摘要: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
摘要翻译: 本文公开了由以下通式表示的多分析蛋白酶的抑制剂:本文公开了组成成分和优选的构成成员。 制备和使用所公开的化合物的方法也在本文中阐述。
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公开(公告)号:US5550262A
公开(公告)日:1996-08-27
申请号:US337795
申请日:1994-11-14
IPC分类号: A61K31/18 , A61K31/216 , A61K31/22 , A61K31/353 , A61K31/4035 , A61K38/00 , C07C279/36 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/08 , C07D209/48 , C07D311/70 , C07F5/02 , C07K5/02 , C07K5/072 , C07C231/00 , C07C255/00
CPC分类号: C07D209/48 , A61K31/18 , A61K31/216 , A61K31/22 , A61K31/353 , A61K31/4035 , C07C279/36 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/08 , C07D311/70 , C07F5/025 , C07K5/0207 , C07K5/06095 , A61K38/00 , C07C2101/08
摘要: Disclosed herein are inbibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
摘要翻译: 本文公开了由下列通式表示的多分析蛋白酶的抑制剂:本文公开了组成成分和优选的组成成分。 制备和使用所公开的化合物的方法也在本文中阐述。
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公开(公告)号:US5990083A
公开(公告)日:1999-11-23
申请号:US816510
申请日:1997-03-13
IPC分类号: A61K31/18 , A61K31/216 , A61K31/22 , A61K31/275 , A61K31/277 , A61K31/353 , A61K31/4035 , A61K31/69 , A61K38/00 , A61K38/55 , A61K45/00 , A61P19/00 , A61P21/00 , A61P43/00 , C07C279/14 , C07C279/34 , C07C279/36 , C07C311/01 , C07C311/06 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/06 , C07C337/08 , C07D209/48 , C07D311/70 , C07F5/02 , C07K5/02 , C07K5/023 , C07K5/072 , C07C231/00 , C07C235/00 , C07C255/00
CPC分类号: C07D209/48 , A61K31/18 , A61K31/216 , A61K31/22 , A61K31/277 , A61K31/353 , A61K31/4035 , C07C279/36 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/08 , C07D311/70 , C07F5/025 , C07K5/0207 , C07K5/06095 , A61K38/00 , C07C2101/08
摘要: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
摘要翻译: 本文公开了由以下通式表示的多分析蛋白酶的抑制剂:本文公开了组成成分和优选的组成成分。 制备和使用所公开的化合物的方法也在本文中阐述。
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公开(公告)号:US20110059959A1
公开(公告)日:2011-03-10
申请号:US12949254
申请日:2010-11-18
申请人: Sankar Chatterjee , James L. Diebold , Derek Dunn , Robert L. Hudkins , Reddeppareddy Dandu , Gregory J. Wells , Allison L. Zulli
发明人: Sankar Chatterjee , James L. Diebold , Derek Dunn , Robert L. Hudkins , Reddeppareddy Dandu , Gregory J. Wells , Allison L. Zulli
IPC分类号: A61K31/5377 , C07D471/14 , A61K31/437 , C07D487/04 , A61K31/407 , C07D413/14 , C07D249/08 , A61K31/4196 , C07D401/12 , A61K31/454 , C07D403/14 , A61K31/496 , A61P25/00 , A61P25/16 , A61P25/28 , A61P9/10 , A61P3/00 , A61P19/02 , A61P17/06 , A61P35/00 , C12N5/02
CPC分类号: C07D491/14 , C07D471/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00
摘要: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
摘要翻译: 本发明涉及介导酶活性的新型多环分子。 特别地,所述化合物可有效治疗与PARP,VEGFR2和MLK3酶的活性相关的疾病或疾病状态,包括例如神经变性疾病,炎症,局部缺血和癌症。
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公开(公告)号:US08716493B2
公开(公告)日:2014-05-06
申请号:US12949254
申请日:2010-11-18
申请人: Sankar Chatterjee , Reddeppa reddy Dandu , James L. Diebold , Derek D. Dunn , Robert L. Hudkins , Gregory J. Wells , Allison L. Zulli
发明人: Sankar Chatterjee , Reddeppa reddy Dandu , James L. Diebold , Derek D. Dunn , Robert L. Hudkins , Gregory J. Wells , Allison L. Zulli
IPC分类号: A61K31/5377 , C07D471/14 , A61K31/407 , C07D487/04 , A61K31/437 , C07D413/14 , C07D249/08 , A61K31/4196 , C07D403/14 , A61K31/496 , A61P25/00 , A61P25/16 , A61P25/28 , A61P9/10 , A61P3/00 , A61P19/02 , A61P17/06 , A61P35/00 , C12N5/02
CPC分类号: C07D491/14 , C07D471/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00
摘要: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
摘要翻译: 本发明涉及介导酶活性的新型多环分子。 特别地,所述化合物可有效治疗与PARP,VEGFR2和MLK3酶的活性相关的疾病或疾病状态,包括例如神经变性疾病,炎症,局部缺血和癌症。
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公开(公告)号:US08471005B2
公开(公告)日:2013-06-25
申请号:US13160890
申请日:2011-06-15
申请人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号: C07D487/04 , C07D403/12 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号: C07D487/04
摘要: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译: 本发明提供式I化合物或其盐形式,其中Q 1,Q 2,Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性,可用于治疗增殖性疾病。
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公开(公告)号:US20120028919A1
公开(公告)日:2012-02-02
申请号:US13160890
申请日:2011-06-15
申请人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号: A61K31/5377 , C07D223/16 , A61P35/00 , A61K31/53 , A61K31/695 , C07D487/04 , A61K31/55
CPC分类号: C07D487/04
摘要: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译: 本发明提供式I化合物或其盐形式,其中Q 1,Q 2,Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性,可用于治疗增殖性疾病。
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公开(公告)号:US20120004253A1
公开(公告)日:2012-01-05
申请号:US13234501
申请日:2011-09-16
申请人: Nadine C. Becknell , Peter D. Brown , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Reddeppareddy Dandu , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人: Nadine C. Becknell , Peter D. Brown , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Reddeppareddy Dandu , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号: A61K31/506 , A61P35/00 , A61P29/00 , A61P25/08 , A61P17/06 , A61P9/10 , A61P17/02 , A61P25/28 , C07D487/14 , A61P19/02
CPC分类号: C07D487/14 , C07D487/04
摘要: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译: 本发明一般涉及选择的稠合吡咯并唑,包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号:US5801190A
公开(公告)日:1998-09-01
申请号:US827215
申请日:1997-03-28
IPC分类号: A61K31/00 , A61K31/40 , A61K31/404 , A61K31/407 , A61P5/36 , A61P25/00 , A61P25/16 , A61P25/28 , A61P31/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/04 , C07D487/04 , C07D487/14 , C07D491/14 , C07D491/147 , C07D493/14 , C07D495/14
CPC分类号: C07D487/04 , C07D487/14 , C07D493/14 , C07D495/14
摘要: Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo�2,3-c!carbazole-6-ones. These molecules are represented by the following general formulae: ##STR1## Methods for making and using the fused pyrrolo�2,3-c!carbazole-6-ones are also disclosed.
摘要翻译: 在该专利文献中公开了称为稠合吡咯并[2,3-c]咔唑-6-酮的合成的生物活性分子。 这些分子由以下通式表示:也公开了使用稠合的吡咯并[2,3-c]咔唑-6-酮。
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