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公开(公告)号:US20120219967A1
公开(公告)日:2012-08-30
申请号:US13367102
申请日:2012-02-06
申请人: Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
发明人: Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
CPC分类号: C07K14/70571 , C07K14/723 , C07K2319/00
摘要: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要翻译: 本发明描述了新的胆碱能/ 5-羟色胺能嵌合受体,并且提供了适合于筛选配体的方法和组合物,例如α7烟碱乙酰胆碱受体的激动剂,拮抗剂和变构调节剂。
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公开(公告)号:US20090123945A1
公开(公告)日:2009-05-14
申请号:US12146088
申请日:2008-06-25
申请人: Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
发明人: Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
CPC分类号: C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要翻译: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体,并且提供适用于筛选配体的方法和组合物,例如α7烟碱乙酰胆碱受体的激动剂,拮抗剂和变构调节剂。
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公开(公告)号:US08759504B2
公开(公告)日:2014-06-24
申请号:US13367102
申请日:2012-02-06
申请人: Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
发明人: Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
IPC分类号: C12N15/62 , G01N33/567 , C07K14/705
CPC分类号: C07K14/70571 , C07K14/723 , C07K2319/00
摘要: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要翻译: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体,并且提供了适合于筛选诸如α7烟碱乙酰胆碱受体的激动剂,拮抗剂和变构调节剂的配体的方法和组合物。
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公开(公告)号:US08609713B2
公开(公告)日:2013-12-17
申请号:US12775735
申请日:2010-05-07
申请人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号: A61K31/40 , C07D207/30
CPC分类号: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本发明涉及一系列取代的吡咯衍生物,包含其的组合物,以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US07683084B2
公开(公告)日:2010-03-23
申请号:US11769241
申请日:2007-06-27
申请人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li , Kathy A. Sarris , Melissa J. Michmerhuizen , Ying Wang
发明人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li , Kathy A. Sarris , Melissa J. Michmerhuizen , Ying Wang
IPC分类号: A61K31/427 , A61K31/343 , A61K31/4025 , C07D317/06 , C07D277/18 , C07D407/14
CPC分类号: C07D417/04 , C07D413/04 , C07D417/14
摘要: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
摘要翻译: 本发明涉及一系列噻唑啉和恶唑啉衍生物,其组合物,以及使用这些化合物治疗病症和病症的方法。
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公开(公告)号:US20100216748A1
公开(公告)日:2010-08-26
申请号:US12775735
申请日:2010-05-07
申请人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号: A61K31/655 , C07D207/34 , A61K31/402 , A61P25/28 , A61P29/00 , A61P25/34 , A61P17/02 , A61P19/02 , A61P37/06 , A61P1/04 , A61P25/24 , A61P25/18 , C07D405/10 , A61K31/4025 , C07D409/10 , C07D401/10 , A61K31/4439 , C07D413/10 , A61K31/5377 , C07D403/12 , A61K31/454 , C12Q1/02
CPC分类号: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本发明涉及一系列取代的吡咯衍生物,包含其的组合物,以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号:US07741364B2
公开(公告)日:2010-06-22
申请号:US11769395
申请日:2007-06-27
申请人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号: A01N43/36
CPC分类号: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本发明涉及一系列取代的吡咯衍生物,包含其的组合物,以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US08470813B2
公开(公告)日:2013-06-25
申请号:US12695567
申请日:2010-01-28
申请人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li , Kathy A. Sarris , Melissa J. Michmerhuizen , Ying Wang
发明人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li , Kathy A. Sarris , Melissa J. Michmerhuizen , Ying Wang
IPC分类号: A61K31/551 , A61K31/426 , A61K31/427 , A61K31/445 , A61K31/421 , A61K31/47 , A61P29/00 , A61P15/08 , A61P19/02 , A61P1/04 , A61P25/00
CPC分类号: C07D417/04 , C07D413/04 , C07D417/14
摘要: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
摘要翻译: 本发明涉及一系列噻唑啉和恶唑啉衍生物,其组合物,以及使用这些化合物治疗病症和病症的方法。
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公开(公告)号:US20100190776A1
公开(公告)日:2010-07-29
申请号:US12695567
申请日:2010-01-28
申请人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li , Kathy A. Sarris , Melissa J. Michmerhuizen , Ying Wang
发明人: Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li , Kathy A. Sarris , Melissa J. Michmerhuizen , Ying Wang
IPC分类号: A61K31/551 , A61K31/426 , A61K31/427 , A61K31/445 , A61K31/421 , A61K31/47 , A61P29/00 , A61P15/08 , A61P19/02 , A61P1/04 , A61P25/00
CPC分类号: C07D417/04 , C07D413/04 , C07D417/14
摘要: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
摘要翻译: 本发明涉及一系列噻唑啉和恶唑啉衍生物,其组合物,以及使用这些化合物治疗病症和病症的方法。
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公开(公告)号:US20080070929A1
公开(公告)日:2008-03-20
申请号:US11769241
申请日:2007-06-27
申请人: Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid Kouhen , Jinhe Li , Kathy Sarris , Melissa Michmerhuizen , Ying Wang
发明人: Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid Kouhen , Jinhe Li , Kathy Sarris , Melissa Michmerhuizen , Ying Wang
IPC分类号: A61K31/427 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61P25/00 , A61P29/00 , A61P37/00 , C07D417/02 , C07D417/14 , C12Q1/02
CPC分类号: C07D417/04 , C07D413/04 , C07D417/14
摘要: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
摘要翻译: 本发明涉及一系列噻唑啉和恶唑啉衍生物,其组合物,以及使用这些化合物治疗病症和病症的方法。
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