-
公开(公告)号:US20170223937A1
公开(公告)日:2017-08-10
申请号:US15519030
申请日:2015-10-13
发明人: Masato ASAI , Masahide TAKAHASHI , Naoya ASAI , Atsushi ENOMOTO , Kozo UCHIYAMA
IPC分类号: A01K67/027
CPC分类号: A01K67/0276 , A01K2207/25 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , C12N15/09 , G01N33/5088 , G01N2800/2857
摘要: Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the Girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below. (1) hippocampal sclerosis should be present, (2) extrahippocampal brain damage should be limited, and (3) spontaneous epilepsy that can be said to be of hippocampal origin should be present.