公开(公告)号：US20200340915A1

公开(公告)日：2020-10-29

申请号：US16961502

申请日：2019-01-18

申请人： NITTO DENKO CORPORATION

发明人： Kazuya MIWA ,  Ryota MASUDA ,  Makoto MIYAHARA ,  Takashi TSUJI ,  Mitsuhiko HORI

IPC分类号： G01N21/53 ,  B01D61/18 ,  G01N33/49 ,  G01B3/1005 ,  A61M27/00

摘要： Provided is a flow path that can easily feed a liquid in the flow path. A flow path (210) is the flow path (210) for feeding a liquid, at least a portion of the flow path (210) includes a first region having a plurality of first through-holes for maintaining a pressure in the flow path (210) at atmospheric pressure, and a second region having an affinity for the liquid, and the liquid is fed by a force caused by affinity for the second region.

公开(公告)号：US20130317206A1

公开(公告)日：2013-11-28

申请号：US13901266

申请日：2013-05-23

申请人： Nitto Denko Corporation

发明人： Eri MAETA ,  Kenjiro MORI ,  Kazuya MIWA

IPC分类号： C08F22/10 ,  C07H21/04

CPC分类号： C08F22/105 ,  C07B35/04 ,  C07B61/02 ,  C07H19/04 ,  C07H19/06 ,  C07H19/16 ,  C07H21/04 ,  C08F2/18 ,  C08F8/12 ,  C08F12/22 ,  C08F212/08 ,  C08F212/36 ,  C08F2800/20 ,  C08F2220/286 ,  C08F212/14

摘要： The present invention provides a solid-phase support for oligonucleotide synthesis for synthesizing long chain oligonucleotide, RNA oligonucleotide and modified oligonucleotide at high synthetic quantity and high purity with a low loading amount of a linker. Provided is a solid-phase support for oligonucleotide synthesis comprising a porous resin bead having a monovinyl monomer unit, a crosslinkable vinyl monomer unit and a polyethylene glycol unit and a cleavable linker loaded on its surface, the porous resin bead having a group capable of binding to a carboxy group by a dehydration condensation reaction on its surface, the cleavable linker having a carboxy group, wherein the carboxy group of the cleavable linker is bound to the group capable of binding to a carboxy group, by a dehydration condensation reaction, and a loading amount of the cleavable linker is 1 to 80 μmol/g relative to the weight of the porous resin bead.

摘要翻译： 本发明提供了一种用于合成高链寡核苷酸，RNA寡核苷酸和高合成量和高纯度的具有低负载量的接头的高纯度的修饰的寡核苷酸的寡核苷酸合成的固相支持物。 提供了一种用于寡核苷酸合成的固相载体，其包含具有单乙烯基单体单元，可交联乙烯基单体单元和聚乙二醇单元的多孔树脂珠粒和其表面上负载的可切割连接物，所述多孔树脂珠粒具有能够结合的基团 通过其表面上的脱水缩合反应与羧基反应，可切割接头具有羧基，其中可切割接头的羧基通过脱水缩合反应与能结合羧基的基团结合，并且 可切割接头的负载量相对于多孔树脂珠的重量为1〜80μmol/ g。