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公开(公告)号:US08383813B2
公开(公告)日:2013-02-26
申请号:US13234501
申请日:2011-09-16
申请人: Nadine C. Becknell , Peter D. Brown , Reddeppareddy Dandu , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人: Nadine C. Becknell , Peter D. Brown , Reddeppareddy Dandu , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号: C07D239/42 , C07D403/14
CPC分类号: C07D487/14 , C07D487/04
摘要: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
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公开(公告)号:US20120004253A1
公开(公告)日:2012-01-05
申请号:US13234501
申请日:2011-09-16
申请人: Nadine C. Becknell , Peter D. Brown , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Reddeppareddy Dandu , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人: Nadine C. Becknell , Peter D. Brown , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Reddeppareddy Dandu , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号: A61K31/506 , A61P35/00 , A61P29/00 , A61P25/08 , A61P17/06 , A61P9/10 , A61P17/02 , A61P25/28 , C07D487/14 , A61P19/02
CPC分类号: C07D487/14 , C07D487/04
摘要: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译: 本发明一般涉及选择的稠合吡咯并唑,包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号:US20100152196A1
公开(公告)日:2010-06-17
申请号:US12708306
申请日:2010-02-18
申请人: Nadine C. Becknell , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Dandu R. Reddy , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人: Nadine C. Becknell , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Dandu R. Reddy , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号: A61K31/501 , A61K31/506 , A61K31/4439 , A61K31/4162 , C07D487/14 , A61P25/16 , A61P25/00 , A61P25/28
CPC分类号: C07D487/14 , C07D487/04
摘要: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译: 本发明一般涉及选择的稠合吡咯并唑,包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号:US07169802B2
公开(公告)日:2007-01-30
申请号:US11017947
申请日:2004-12-22
申请人: Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
发明人: Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
IPC分类号: A61K31/4162 , A61K31/506 , A61K31/407 , C07D239/42 , C07D231/54 , C07D487/14
CPC分类号: C07D487/14 , C07D487/04
摘要: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
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公开(公告)号:US07671064B2
公开(公告)日:2010-03-02
申请号:US11477639
申请日:2006-06-29
申请人: Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
发明人: Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
IPC分类号: A61K31/506 , A61K31/416 , A61K31/4162 , C07D231/54
CPC分类号: C07D487/14 , C07D487/04
摘要: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译: 本发明一般涉及选择的稠合吡咯并唑,包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号:US08471005B2
公开(公告)日:2013-06-25
申请号:US13160890
申请日:2011-06-15
申请人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号: C07D487/04 , C07D403/12 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号: C07D487/04
摘要: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译: 本发明提供式I化合物或其盐形式,其中Q 1,Q 2,Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性,可用于治疗增殖性疾病。
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公开(公告)号:US20120028919A1
公开(公告)日:2012-02-02
申请号:US13160890
申请日:2011-06-15
申请人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号: A61K31/5377 , C07D223/16 , A61P35/00 , A61K31/53 , A61K31/695 , C07D487/04 , A61K31/55
CPC分类号: C07D487/04
摘要: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译: 本发明提供式I化合物或其盐形式,其中Q 1,Q 2,Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性,可用于治疗增殖性疾病。
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公开(公告)号:US08354414B2
公开(公告)日:2013-01-15
申请号:US12939527
申请日:2010-11-04
申请人: Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
发明人: Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
IPC分类号: C07D239/70 , C07D471/04 , A61K31/517 , A61K31/519 , C07D239/72 , C07D239/84 , C07D239/78 , C07D487/04
CPC分类号: C07D401/14 , C07D403/04 , C07D487/04
摘要: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译: 本发明涉及化学组成,其制备方法和组合物的用途。 特别地,本发明涉及包含式(I)的取代杂双环嘧啶的组合物:其中R 1,R 2,R 3,R 4,R 5,X,W和环A如本文所定义; 式(I)的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病,神经创伤性疾病,抑郁症和/或糖尿病的用途。 更具体地,本发明涉及式(I)的取代的吡唑并嘧啶。
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公开(公告)号:US20110053920A1
公开(公告)日:2011-03-03
申请号:US12939527
申请日:2010-11-04
申请人: Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
发明人: Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
IPC分类号: A61K31/541 , C07D487/04 , A61K31/519 , C07D471/04 , C07D413/14 , A61K31/5377 , A61K31/517 , C07D417/14 , C07D473/00 , A61K31/52 , A61P25/00 , A61P29/00 , A61P9/00 , A61P3/10 , A61P3/04
CPC分类号: C07D401/14 , C07D403/04 , C07D487/04
摘要: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译: 本发明涉及化学组成,其制备方法和组合物的用途。 特别地,本发明涉及包含式(I)的取代杂双环嘧啶的组合物:其中R 1,R 2,R 3,R 4,R 5,X,W和环A如本文所定义; 式(I)的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病,神经创伤性疾病,抑郁症和/或糖尿病的用途。 更具体地,本发明涉及式(I)的取代的吡唑并嘧啶。
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公开(公告)号:US07851468B2
公开(公告)日:2010-12-14
申请号:US11803320
申请日:2007-05-14
申请人: Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
发明人: Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
IPC分类号: A61K31/541 , A61K31/5355 , A61K31/497 , A61K31/519 , C07D279/12 , C07D417/14 , C07D413/14 , C07D519/00 , C07D487/04 , A61K31/517
CPC分类号: C07D401/14 , C07D403/04 , C07D487/04
摘要: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译: 本发明涉及化学组成,其制备方法和组合物的用途。 特别地,本发明涉及包含式(I)的取代杂双环嘧啶的组合物:其中R 1,R 2,R 3,R 4,R 5,X,W和环A如本文所定义; 式(I)的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病,神经创伤性疾病,抑郁症和/或糖尿病的用途。 更具体地,本发明涉及式(I)的取代的吡唑并嘧啶。
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