BIOSENSOR ELEMENT AND METHOD FOR MANUFACTURING THE SAME
    9.
    发明申请
    BIOSENSOR ELEMENT AND METHOD FOR MANUFACTURING THE SAME 审中-公开
    生物传感器元件及其制造方法

    公开(公告)号:US20080014581A1

    公开(公告)日:2008-01-17

    申请号:US11670501

    申请日:2007-02-02

    摘要: A biosensor is formed by immobilizing metal particles immobilized on a surface of a carrier and immobilizing probe molecules which are modified with fluorescent molecules on the metal particles. A biomolecule is detected at high sensitivity by use of this biosensor and utilizing fluorescence-quenching and fluorescence-enhancement effects attributable to the metal particle. In this way, it is possible to omit amplification of the biomolecule in a specimen and fluorescence-labeling on the biomolecule when detecting the biomolecule with the biosensor. It is also possible to improve quantitative reliability and repeatability of the biosensor.

    摘要翻译: 通过固定固定在载体表面上的金属颗粒并将在荧光分子上修饰的探针分子固定在金属颗粒上而形成生物传感器。 通过使用该生物传感器以高灵敏度检测生物分子,并利用归因于金属颗粒的荧光猝灭和荧光增强效应。 以这种方式,当用生物传感器检测生物分子时,可以省略样品中的生物分子的扩增和生物分子上的荧光标记。 也可以提高生物传感器的定量可靠性和重复性。