公开(公告)号：US08945107B2

公开(公告)日：2015-02-03

申请号：US13279327

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20120136417A1

公开(公告)日：2012-05-31

申请号：US13279327

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20120136344A1

公开(公告)日：2012-05-31

申请号：US13279321

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US09439708B2

公开(公告)日：2016-09-13

申请号：US13279326

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US09060754B2

公开(公告)日：2015-06-23

申请号：US13279328

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00255 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment includes an elongated shaft and a cooling assembly at a distal portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site within or otherwise proximate a renal artery. The cryotherapeutic device can further include a supply lumen configured to carry liquid refrigerant toward the cooling assembly. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据特定实施例构造的冷冻治疗装置包括细长轴和在轴的远端部分处的冷却组件。 轴可以被配置为将血管内远端部分定位在肾动脉内或其他邻近肾动脉处的处置部位。 冷冻治疗装置还可以包括被配置为将液体制冷剂运送到冷却组件的供应管腔。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US20120130360A1

公开(公告)日：2012-05-24

申请号：US13279326

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20120136418A1

公开(公告)日：2012-05-31

申请号：US13279328

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00255 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US20120150267A1

公开(公告)日：2012-06-14

申请号：US13279330

申请日：2011-10-23

申请人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

发明人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US09060755B2

公开(公告)日：2015-06-23

申请号：US13279330

申请日：2011-10-23

申请人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

发明人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US20130289549A1

公开(公告)日：2013-10-31

申请号：US13458120

申请日：2012-04-27

申请人： Stephen Nash ,  Grace Kelly

发明人： Stephen Nash ,  Grace Kelly

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B90/03 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268 ,  A61B2090/032 ,  A61B2090/037 ,  A61M25/1006 ,  A61M25/10184 ,  A61M25/1025 ,  A61M2025/1061 ,  F04C2270/041

摘要： Cryotherapeutic systems with features that can facilitate pressure relief in the event of exhaust-passage blockage and associated devices, systems, and methods are disclosed herein. A cryotherapeutic system configured in accordance with a particular embodiment can include an elongated shaft having a distal portion and a pressure-relief portion proximal to the distal portion. The cryotherapeutic system can further include a supply lumen, an exhaust passage, and a balloon configured to receive refrigerant from the supply lumen and to exhaust refrigerant to the exhaust passage. The pressure-relief portion can be configured to release refrigerant from the exhaust passage when a pressure of refrigerant in the exhaust passage exceeds a threshold pressure less than a pressure rating of the balloon. The pressure-relief portion, for example, can include a rupture element configured to rupture at about the threshold pressure.

摘要翻译： 本文公开了具有能够促进在排气通道堵塞的情况下的压力释放以及相关的装置，系统和方法的特征的冷冻治疗系统。 根据特定实施例构造的冷冻治疗系统可以包括细长轴，其具有远侧部分和靠近远端部分的压力释放部分。 冷冻治疗系统还可以包括供应管腔，排气通道和被配置为从供应管腔接纳制冷剂并将制冷剂排出到排气通道的气囊。 当排气通道中的制冷剂的压力超过小于气囊的额定压力的阈值压力时，减压部分可被构造成从排气通道释放制冷剂。 例如，减压部分可以包括构造成在约阈值压力下破裂的断裂元件。