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公开(公告)号:US08546380B2
公开(公告)日:2013-10-01
申请号:US13243971
申请日:2011-09-23
申请人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号: C07D279/00 , C07D265/00 , A61K31/535 , A61K31/541
CPC分类号: C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要: A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.
摘要翻译: 一种具有BACE1抑制活性的组合物,其含有式(I)表示的化合物:其中环A为任选取代的杂环基; E为低级亚烷基; X是S; R1是氢原子或低级烷基; R2a,R2b,R3a,R3b,R4a和R4b各自独立地为氢原子,卤素或羟基等; n和m各自独立地为0〜3的整数, n + m为0〜3的整数, R5是氢原子或取代的低级烷基; 或其药学上可接受的盐。
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公开(公告)号:US08633188B2
公开(公告)日:2014-01-21
申请号:US13243874
申请日:2011-09-23
申请人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号: A61K31/535 , A61K31/541 , C07D279/00 , C07D265/00
CPC分类号: C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译: 一种具有BACE1抑制活性的组合物,其含有通式(I)表示的化合物:其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S,O或NR1; R1是氢原子或低级烷基; R2a,R2b,R3a,R3b,R4a和R4b各自独立地为氢原子,卤素或羟基等; n和m各自独立地为0〜3的整数, n + m为0〜3的整数, R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。
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公开(公告)号:US08173642B2
公开(公告)日:2012-05-08
申请号:US12089409
申请日:2006-10-23
申请人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号: C07D417/12 , C07D417/14 , A61K31/497 , A61K31/54
CPC分类号: C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译: 一种具有BACE1抑制活性的组合物,其含有通式(I)表示的化合物:其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S,O或NR1; R1是氢原子或低级烷基; R2a,R2b,R3a,R3b,R4a和R4b各自独立地为氢原子,卤素或羟基等; n和m各自独立地为0〜3的整数, n + m为0〜3的整数, R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。
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公开(公告)号:US20090082560A1
公开(公告)日:2009-03-26
申请号:US12089409
申请日:2006-10-23
申请人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号: C07D267/06 , C07D417/12 , C07D279/06 , C07D277/18
CPC分类号: C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译: 一种具有BACE1抑制活性的组合物,其含有通式(I)表示的化合物:其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S,O或NR1; R1是氢原子或低级烷基; R2a,R2b,R3a,R3b,R4a和R4b各自独立地为氢原子,卤素或羟基等; n和m各自独立地为0〜3的整数, n + m为0〜3的整数, R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。
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公开(公告)号:US20100160290A1
公开(公告)日:2010-06-24
申请号:US12597470
申请日:2008-04-23
申请人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号: A61K31/554 , C07D417/02 , A61K31/541 , C07D279/06 , C07D277/18 , A61K31/426 , C07D239/02 , A61K31/506 , C07D281/02 , A61P25/28
CPC分类号: C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要: A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译: 一种用于治疗含有由通式(I)表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S,O或NR1; R1是氢原子或低级烷基; R2a,R2b,R3a,R3b,R4a和R4b各自独立地为氢原子,卤素,羟基等; n和m各自独立地为0〜3的整数, n + m为1〜3的整数, R5为氢原子,任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。
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公开(公告)号:US08653067B2
公开(公告)日:2014-02-18
申请号:US12597470
申请日:2008-04-23
申请人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
发明人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
IPC分类号: A61K31/554 , A61K31/541 , A61K31/426 , A61K31/506 , C07D417/02 , C07D279/06 , C07D277/18 , C07D239/02
CPC分类号: C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要: A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译: 一种用于治疗含有由通式(I)表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S,O或NR1; R1是氢原子或低级烷基; R2a,R2b,R3a,R3b,R4a和R4b各自独立地为氢原子,卤素,羟基等; n和m各自独立地为0〜3的整数, n + m为1〜3的整数, R5为氢原子,任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。
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7.
公开(公告)号:US10243260B2
公开(公告)日:2019-03-26
申请号:US15479899
申请日:2017-04-05
申请人: Naohiro Itoh
发明人: Naohiro Itoh
摘要: An antenna unit includes an antenna prepared by winding conducting wire around a magnetic body. The antenna unit also includes a metal housing to accommodate the antenna. The metal housing includes a first cut-out to allow a magnetic field generated by the antenna to pass through the metal housing.
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8.
公开(公告)号:US20150229346A1
公开(公告)日:2015-08-13
申请号:US14428238
申请日:2013-09-11
IPC分类号: H04B1/40 , H04B1/3827 , H04B15/00 , H03F3/19
CPC分类号: H04B1/40 , G06K19/0723 , G06K19/0726 , H03D1/00 , H03F3/19 , H03F3/24 , H03F2200/451 , H04B1/3827 , H04B5/0031 , H04B5/0056 , H04B15/00 , H04B2001/0408
摘要: An amplifier circuit that amplifies a carrier wave that a transmitting and receiving part has received, and includes a superimposition wave generation part that generates a superimposition wave to be superimposed onto the carrier wave; an amplifying part that adds the carrier wave and the superimposition wave to obtain an amplified carrier wave and outputs the amplified carrier wave; and an amplitude detection part that detects, based on a change in an amplitude value of the carrier wave, that the carrier wave is a predetermined carrier wave that carries a predetermined communication signal. The amplifier circuit outputs the amplified carrier wave when having detected the predetermined carrier wave.
摘要翻译: 放大电路,放大发送和接收部分已经接收到的载波,并且包括产生叠加在载波上的叠加波的叠加波产生部分; 放大部分,其加载载波和叠加波以获得放大的载波并输出放大的载波; 以及振幅检测部,其基于载波的振幅值的变化来检测载波是携带预定通信信号的预定载波。 当检测到预定的载波时,放大器电路输出放大的载波。
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公开(公告)号:US10305187B2
公开(公告)日:2019-05-28
申请号:US15459512
申请日:2017-03-15
申请人: Naohiro Itoh
发明人: Naohiro Itoh
摘要: An antenna device includes: a plated magnetic body; a conductive wire that is wound around the magnetic body; and a substrate that relays the conductive wire and a connector.
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10.
公开(公告)号:US09407312B2
公开(公告)日:2016-08-02
申请号:US14428238
申请日:2013-09-11
CPC分类号: H04B1/40 , G06K19/0723 , G06K19/0726 , H03D1/00 , H03F3/19 , H03F3/24 , H03F2200/451 , H04B1/3827 , H04B5/0031 , H04B5/0056 , H04B15/00 , H04B2001/0408
摘要: An amplifier circuit that amplifies a carrier wave that a transmitting and receiving part has received, and includes a superimposition wave generation part that generates a superimposition wave to be superimposed onto the carrier wave; an amplifying part that adds the carrier wave and the superimposition wave to obtain an amplified carrier wave and outputs the amplified carrier wave; and an amplitude detection part that detects, based on a change in an amplitude value of the carrier wave, that the carrier wave is a predetermined carrier wave that carries a predetermined communication signal. The amplifier circuit outputs the amplified carrier wave when having detected the predetermined carrier wave.
摘要翻译: 放大电路,放大发送和接收部分已经接收到的载波,并且包括产生叠加在载波上的叠加波的叠加波产生部分; 放大部分,其加载载波和叠加波以获得放大的载波并输出放大的载波; 以及振幅检测部,其基于载波的振幅值的变化来检测载波是携带预定通信信号的预定载波。 当检测到预定的载波时,放大器电路输出放大的载波。
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