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公开(公告)号：US20240336980A1
公开(公告)日：2024-10-10
申请号：US18747178
申请日：2024-06-18
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/6886 , C12Q1/6869 , G06N7/01 , G06N20/00 , G16B15/00 , G16B20/00 , G16B20/10 , G16B20/20 , G16B25/00 , G16B25/20 , G16B40/00 , G16B40/20 , G16H10/40 , G16H50/20 , G16Z99/00
CPC分类号： C12Q1/6886 , C12Q1/6869 , G06N7/01 , G06N20/00 , G16B15/00 , G16B20/00 , G16B20/10 , G16B20/20 , G16B25/00 , G16B40/00 , G16B40/20 , G16H10/40 , G16H50/20 , G16Z99/00 , C12Q2539/10 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G16B25/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US20240336970A1
公开(公告)日：2024-10-10
申请号：US18751153
申请日：2024-06-21
申请人： Natera, Inc.
发明人： Matthew Rabinowitz , Matthew Micah Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US11591649B2
公开(公告)日：2023-02-28
申请号：US16796748
申请日：2020-02-20
申请人： Natera, Inc.
发明人： Matthew Rabinowitz , Matthew Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC分类号： C12Q1/6869 , G16B10/00 , C12Q1/6876 , C12Q1/6844
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
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公开(公告)号：US11447827B2
公开(公告)日：2022-09-20
申请号：US16014961
申请日：2018-06-21
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/6886 , C12Q1/6869 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16B20/20 , G16H50/20 , G06N7/00 , G16H10/40 , G06F19/00 , G16B25/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US11408031B2
公开(公告)日：2022-08-09
申请号：US16012667
申请日：2018-06-19
申请人： Natera, Inc.
发明人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko , Bernhard Zimmerman
IPC分类号： C12Q1/68 , C12Q1/6869 , C12Q1/6876 , C12Q1/6844 , G16B10/00
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
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公开(公告)号：US10655180B2
公开(公告)日：2020-05-19
申请号：US16353636
申请日：2019-03-14
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6855 , C12Q1/6874
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US10577650B2
公开(公告)日：2020-03-03
申请号：US15716331
申请日：2017-09-26
申请人： Natera, Inc.
发明人： Bernhard Zimmermann , Ryan Swenerton , Matthew Rabinowitz , Styrmir Sigurjonsson , George Gemelos , Apratim Ganguly , Himanshu Sethi
IPC分类号： C12Q1/6869 , C12Q1/6806
摘要： The present disclosure provides methods and compositions for sequencing nucleic acid molecules and identifying individual sample nucleic acid molecules using Molecular Index Tags (MITs). Furthermore, reaction mixtures, kits, and adapter libraries are provided.
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公开(公告)号：US10522242B2
公开(公告)日：2019-12-31
申请号：US15343003
申请日：2016-11-03
申请人： Natera, Inc.
IPC分类号： G01N33/50 , G16B30/00 , G16B20/00 , C12Q1/6827 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , G06N7/00
摘要： Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.
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公开(公告)号：US10011870B2
公开(公告)日：2018-07-03
申请号：US15372279
申请日：2016-12-07
申请人： Natera, Inc.
发明人： Bernhard Zimmermann , Ryan Swenerton , Matthew Rabinowitz , Styrmir Sigurjonsson , George Gemelos , Apratim Ganguly , Himanshu Sethi
IPC分类号： C12Q1/68 , C12Q1/6869 , C12Q1/6806
摘要： The present disclosure provides methods and compositions for sequencing nucleic acid molecules and identifying individual sample nucleic acid molecules using Molecular Index Tags (MITs). Furthermore, reaction mixtures, kits, and adapter libraries are provided.
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公开(公告)号：US20160369346A1
公开(公告)日：2016-12-22
申请号：US15252795
申请日：2016-08-31
申请人： Natera, Inc.
CPC分类号： G16B30/00 , C12Q1/6827 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06N7/005 , G16B20/00 , C12Q2537/16 , C12Q2537/165
摘要： Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.
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