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公开(公告)号:US11447827B2
公开(公告)日:2022-09-20
申请号:US16014961
申请日:2018-06-21
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/6886 , C12Q1/6869 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16B20/20 , G16H50/20 , G06N7/00 , G16H10/40 , G06F19/00 , G16B25/20
摘要: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US10655180B2
公开(公告)日:2020-05-19
申请号:US16353636
申请日:2019-03-14
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6855 , C12Q1/6874
摘要: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号:US11414709B2
公开(公告)日:2022-08-16
申请号:US16359917
申请日:2019-03-20
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/6886 , C12Q1/6869 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/20 , G16H50/20 , G06N7/00 , G16H10/40 , G16Z99/00 , G16B20/00 , G16B25/20
摘要: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US11319596B2
公开(公告)日:2022-05-03
申请号:US16288351
申请日:2019-02-28
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/6886 , C12Q1/6869 , G16B20/20 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16Z99/00 , G16H50/20 , G06N7/00 , G16H10/40 , G16B25/20
摘要: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US11319595B2
公开(公告)日:2022-05-03
申请号:US15898145
申请日:2018-02-15
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/6886 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , C12Q1/6869 , G16B40/20 , G16B20/10 , G16B20/00 , G16B20/20 , G16Z99/00 , G16H50/20 , G06N7/00 , G16H10/40 , G16B25/20
摘要: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US10316362B2
公开(公告)日:2019-06-11
申请号:US14918544
申请日:2015-10-20
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/68 , C12Q1/6874 , C12Q1/6811 , C12Q1/6848 , C12Q1/6855 , C12Q1/6883
摘要: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号:US20160369333A1
公开(公告)日:2016-12-22
申请号:US14918544
申请日:2015-10-20
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Sakarya Onur , Styrmir Sigurjonsson , Bernhard Zimmerman
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6874 , C12Q1/6811 , C12Q1/6848 , C12Q1/6855 , C12Q1/6883 , C12Q2600/156 , C12Q2527/107 , C12Q2537/143
摘要: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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8.
公开(公告)号:US20160333416A1
公开(公告)日:2016-11-17
申请号:US14882763
申请日:2015-10-14
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
CPC分类号: G06F19/22 , C12Q1/6811 , C12Q1/6848 , C12Q1/6883 , C12Q2600/156 , C12Q2527/107 , C12Q2537/143
摘要: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
摘要翻译: 本发明提供用于检测染色体片段或整个染色体的倍性的方法,系统和计算机可读介质,用于检测单核苷酸变体和检测染色体片段和单核苷酸变体的倍性。 在一些方面,本发明提供了用于检测胎儿胎儿的癌症或染色体异常的方法,系统和计算机可读介质。
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公开(公告)号:US11486008B2
公开(公告)日:2022-11-01
申请号:US16014961
申请日:2018-06-21
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/6886 , C12Q1/6869 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16B20/20 , G16H50/20 , G06N7/00 , G16H10/40 , G06F19/00 , G16B25/20
摘要: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US11408037B2
公开(公告)日:2022-08-09
申请号:US16288416
申请日:2019-02-28
申请人: Natera, Inc.
发明人: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号: C12Q1/6886 , C12Q1/6869 , G16B20/00 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/20 , G16Z99/00 , G16H50/20 , G06N7/00 , G16H10/40 , G16B25/20
摘要: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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