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公开(公告)号:US12065703B2
公开(公告)日:2024-08-20
申请号:US18120873
申请日:2023-03-13
Applicant: Natera, Inc.
Inventor: Matthew Rabinowitz , Milena Banjevic , Zachary Demko , David Johnson , Dusan Kijacic , Dimitri Petrov , Joshua Sweetkind-Singer , Jing Xu
IPC: C12Q1/68 , C12Q1/6806 , C12Q1/6827 , C12Q1/6855 , C12Q1/6869 , C12Q1/6876 , C12Q1/6883 , C12Q1/6886 , G16B20/00 , G16B25/00 , G16B30/00 , G16B40/00
CPC classification number: C12Q1/6883 , C12Q1/6806 , C12Q1/6827 , C12Q1/6855 , C12Q1/6869 , C12Q1/6876 , C12Q1/6886 , G16B20/00 , G16B25/00 , G16B30/00 , G16B40/00 , C12Q2537/149 , C12Q2545/114 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.
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公开(公告)号:US20240060124A1
公开(公告)日:2024-02-22
申请号:US18227786
申请日:2023-07-28
Applicant: Natera, Inc.
Inventor: Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
IPC: C12Q1/6869 , C12Q1/6844 , C12Q1/6876 , G16B10/00
CPC classification number: C12Q1/6869 , C12Q1/6844 , C12Q1/6876 , G16B10/00 , C12Q2600/156
Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
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公开(公告)号:US11525162B2
公开(公告)日:2022-12-13
申请号:US16829133
申请日:2020-03-25
Applicant: Natera, Inc.
Inventor: Matthew Rabinowitz , Matthew Micah Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC: C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6844 , C12Q1/6855 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号:US11519035B2
公开(公告)日:2022-12-06
申请号:US16934407
申请日:2020-07-21
Applicant: Natera, Inc.
Inventor: Matthew Rabinowitz , Matthew Micah Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC: C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6844 , C12Q1/6869 , C12Q1/6855 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号:US11486008B2
公开(公告)日:2022-11-01
申请号:US16014961
申请日:2018-06-21
Applicant: Natera, Inc.
Inventor: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC: C12Q1/6886 , C12Q1/6869 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16B20/20 , G16H50/20 , G06N7/00 , G16H10/40 , G06F19/00 , G16B25/20
Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US11459615B2
公开(公告)日:2022-10-04
申请号:US16829133
申请日:2020-03-25
Applicant: Natera, Inc.
Inventor: Matthew Rabinowitz , Matthew Micah Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC: C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6844 , C12Q1/6855 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号:US11408037B2
公开(公告)日:2022-08-09
申请号:US16288416
申请日:2019-02-28
Applicant: Natera, Inc.
Inventor: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC: C12Q1/6886 , C12Q1/6869 , G16B20/00 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/20 , G16Z99/00 , G16H50/20 , G06N7/00 , G16H10/40 , G16B25/20
Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US11371100B2
公开(公告)日:2022-06-28
申请号:US16288462
申请日:2019-02-28
Applicant: Natera, Inc.
Inventor: Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC: C12Q1/6886 , C12Q1/6869 , G16B20/20 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16Z99/00 , G16H50/20 , G06N7/00 , G16H10/40 , G16B25/20
Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号:US11345960B2
公开(公告)日:2022-05-31
申请号:US16012667
申请日:2018-06-19
Applicant: Natera, Inc.
Inventor: Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko , Bernhard Zimmerman
IPC: C12Q1/68 , C12Q1/6869 , C12Q1/6876 , C12Q1/6844 , G16B10/00
Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
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公开(公告)号:US11332793B2
公开(公告)日:2022-05-17
申请号:US16777700
申请日:2020-01-30
Applicant: Natera, Inc.
Inventor: Matthew Rabinowitz , Matthew Micah Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC: C12Q1/68 , C12Q1/6883 , C12Q1/6809 , C12Q1/6874 , C12Q1/6855 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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