公开(公告)号：US20090120873A1

公开(公告)日：2009-05-14

申请号：US12209424

申请日：2008-09-12

申请人： Nathaniel T. Becker ,  Ryszard Braun ,  Robert I. Christensen, JR. ,  Stefan Ekbom ,  Robin Fong ,  Alexandra Schuler

发明人： Nathaniel T. Becker ,  Ryszard Braun ,  Robert I. Christensen, JR. ,  Stefan Ekbom ,  Robin Fong ,  Alexandra Schuler

IPC分类号： B01D65/08 ,  B01D61/22

CPC分类号： B01D65/00 ,  B01D61/14 ,  B01D63/10 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/06 ,  B01D2313/19 ,  B01D2321/02 ,  B01D2321/04 ,  B01D2321/10 ,  B01D2321/12 ,  B01D2321/20 ,  B01D2321/2008 ,  B01D2321/2083 ,  B01D2311/14 ,  B01D2311/165

摘要： Filtration processes and systems are provided for the separation of a filterable fluid stream by a filtration membrane module with uniform transmembrane pressure and flux along the membrane and internal control of membrane fouling via intermittent periodic reduction of the pressure differential between the permeate and retentate sides of the membrane and/or backwashing cycles during separation, recovery, and/or purification of proteins, peptides, nucleic acids, biologically produced polymers and other compounds or materials from aqueous fluids.

摘要翻译： 提供了过滤方法和系统，用于通过过滤膜组件分离可过滤流体流，所述过滤膜组件具有沿着膜的均匀的跨膜压力和通量以及膜污染的内部控制，通过间歇性周期性地减少渗透物和渗余物侧之间的压力差 在从水性流体分离，回收和/或纯化蛋白质，肽，核酸，生物制备的聚合物和其它化合物或其它化合物的过程中，膜和/或反冲洗循环。

公开(公告)号：US08784662B2

公开(公告)日：2014-07-22

申请号：US12209424

申请日：2008-09-12

申请人： Nathaniel T. Becker ,  Ryszard Braun ,  Robert I. Christensen, Jr. ,  Stefan Ekbom ,  Robin Fong ,  Alexandra Schuler

发明人： Nathaniel T. Becker ,  Ryszard Braun ,  Robert I. Christensen, Jr. ,  Stefan Ekbom ,  Robin Fong ,  Alexandra Schuler

IPC分类号： B01D65/02 ,  C02F1/44 ,  B01D65/00 ,  B01D65/08

CPC分类号： B01D65/00 ,  B01D61/14 ,  B01D63/10 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/06 ,  B01D2313/19 ,  B01D2321/02 ,  B01D2321/04 ,  B01D2321/10 ,  B01D2321/12 ,  B01D2321/20 ,  B01D2321/2008 ,  B01D2321/2083 ,  B01D2311/14 ,  B01D2311/165

摘要： Filtration processes and systems are provided for the separation of a filterable fluid stream by a filtration membrane module with uniform transmembrane pressure and flux along the membrane and internal control of membrane fouling via intermittent periodic reduction of the pressure differential between the permeate and retentate sides of the membrane and/or backwashing cycles during separation, recovery, and/or purification of proteins, peptides, nucleic acids, biologically produced polymers and other compounds or materials from aqueous fluids.

摘要翻译： 提供了过滤方法和系统，用于通过过滤膜组件分离可过滤流体流，所述过滤膜组件具有沿着膜的均匀的跨膜压力和通量以及膜污染的内部控制，通过间歇性周期性地减少渗透物和渗余物侧之间的压力差 在从水性流体分离，回收和/或纯化蛋白质，肽，核酸，生物制备的聚合物和其它化合物或其它化合物的过程中，膜和/或反冲洗循环。

公开(公告)号：US06800197B1

公开(公告)日：2004-10-05

申请号：US09689279

申请日：2000-10-12

申请人： Antti Kosola ,  Ryszard Braun ,  Stefan Ekbom

发明人： Antti Kosola ,  Ryszard Braun ,  Stefan Ekbom

IPC分类号： B01D3702

CPC分类号： B01D33/073 ,  B01D33/463 ,  B01D33/466 ,  B01D33/58 ,  B01D33/60 ,  B01D37/02 ,  B01D37/025 ,  B01D37/04 ,  B01D2201/54

摘要： A rotating drum pressure differential filter is provided whereby a layer of filter medium is continuously refreshed by a spray applicator device after the layer is utilized to filter components sample medium and a portion of the layer is subsequently scraped to remove sample medium waste from the layer. Methods of filtration using the device are also provided as are systems employing two or more such filters. A spray applicator device useful for refreshing a filter medium on the outer surface of a rotating drum pressure differential filter is also provided as is a retro fit kit useful in modifying existing rotating drum pressure differential filters to enable the continuous formation of a refreshed filter medium layer. The continuously refreshed filter and filter systems provide a minimized down time of the filter and system operations. Multiple-stage filtration processes are also provided and are particularly in the recovery of enzymes from fermentation broths.

摘要翻译： 提供了旋转鼓压力差压过滤器，其中一层过滤介质在用于过滤组分样品介质的层之后通过喷涂装置连续刷新，并且该层的一部分随后被刮除以从层中去除样品介质废料。 使用该装置的过滤方法也可以采用采用两种或更多种这样的过滤器的系统。 还提供了可用于刷新旋转鼓压差滤波器的外表面上的过滤介质的喷涂器装置，其还可用于修改现有的旋转鼓压差滤波器以使连续形成更新的过滤介质层 。 持续更新的过滤器和过滤系统提供过滤器和系统操作的最小化停机时间。 还提供了多级过滤方法，特别是从发酵液中回收酶。