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    Granule containing protein and salt layered on an inert particle
    5.
    发明授权
    Granule containing protein and salt layered on an inert particle 有权

    公开(公告)号：US06423517B1

    公开(公告)日：2002-07-23

    申请号：US09215086

    申请日：1998-12-18

    申请人： Nathaniel T. Becker ,  Robert I. Christensen, Jr. ,  Ernst H. Gros

    发明人： Nathaniel T. Becker ,  Robert I. Christensen, Jr. ,  Ernst H. Gros

    IPC分类号： C12N998

    摘要： Granules are prepared containing an admixture of protein and salt layered over an inert particle. A preferred amount of salt is about between 63.7 and 84.3% of the total weight of the admixture. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, lipases and cellulases capable of hydrolyzing substrates such as stains. Inert particles include inorganic salts, sugars, sugar alcohols, small organic molecules such as organic acids or salts, and minerals such as clays or silicates. A binder such as starch or polyethylene oxide may be mixed in with the admixture. A barrier material such as an inorganic salt or organic acid or salt may be in the admixture or coated over the admixture layer. A coating layer of a soluble or water dispersible film-forming polymer may be between the inert particle and admixture layer and/or over the admixture layer. The granules may also contain plasticizers, extenders, lubricants, pigments and anti-agglomeration agents. A preferred method for preparing the granules is by spraying a solution or slurry of the admixture onto the inert particles while fluidized in a fluid-bed coater.

    Symmetrical fluidization coater for high capacity manufacturing
    6.
    发明授权
    Symmetrical fluidization coater for high capacity manufacturing 有权
    用于大容量制造的对称流化涂布机

    公开(公告)号：US06461672B1

    公开(公告)日：2002-10-08

    申请号：US09640394

    申请日：2000-08-16

    申请人： Antti Kosola ,  Ryszard Braun ,  Nathaniel T. Becker ,  Robert L. Christensen, Jr. ,  Ville Kyläkoski ,  Alfred L. Gaertner

    发明人： Antti Kosola ,  Ryszard Braun ,  Nathaniel T. Becker ,  Robert L. Christensen, Jr. ,  Ville Kyläkoski ,  Alfred L. Gaertner

    IPC分类号： B05D700

    CPC分类号： B01J2/16 ,  B01J2/006

    摘要： A fluidized bed coating apparatus is provided and includes a fluid inlet adapted to be connected to a source of fluidizing fluid. The fluid inlet has an entrance opening having a first diameter and an exit opening downstream of the entrance opening. The exit opening has a second diameter that is larger than the first diameter. The inlet also includes an expanding inlet section, between the entrance opening and the exit opening, that has an average diameter that increases in a direction from said entrance opening to said exit opening. A fluid distribution plate is provided adjacent the exit opening and includes a plurality of through-passages to allow the even and distributed passage of a fluidizing fluid therethrough. A chamber having a chamber inlet and a chamber outlet is provided and the fluid distribution plate is positioned between the exit opening and the chamber inlet. The chamber includes at least a first diverging section having an average diameter that increases in the direction from the chamber inlet downstream toward the chamber outlet. The symmetrical design of the coater provides an evenly distributed flow of fluid that enables efficient and complete fluidization and coating of very large particle beds.

    摘要翻译： 提供了一种流化床涂覆设备，并包括适于连接到流化流体源的流体入口。 流体入口具有入口，其具有第一直径和入口开口下游的出口。 出口具有大于第一直径的第二直径。 入口还包括在入口和出口之间的扩张入口部分，其具有在从所述入口到所述出口的方向上增加的平均直径。 流体分配板邻近出口设置并且包括多个通道以允许流化流体均匀分布通过其中。 提供具有室入口和室出口的室，并且流体分配板位于出口和室入口之间。 该腔室至少包括第一发散部分，该第一发散部分具有在从腔室入口下游朝向腔室出口的方向上增加的平均直径。 涂布机的对称设计提供均匀分布的流体流动，能够高效，完全地流化和涂覆非常大的颗粒床。

    Delivery system for co-formulated enzyme and substrate
    8.
    发明授权
    Delivery system for co-formulated enzyme and substrate 有权
    配制酶和底物的输送系统

    公开(公告)号：US08834865B2

    公开(公告)日：2014-09-16

    申请号：US13132069

    申请日：2009-11-03

    申请人： Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    发明人： Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    IPC分类号： A61K38/54 ,  C11D3/386 ,  C11D17/00

    CPC分类号： C11D17/0039 ,  C11D3/386 ,  C11D3/38672 ,  C11D3/38681

    摘要： The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a water-soluble polymeric matrix and a substrate for the enzyme in a carrier liquid in which the polymeric matrix is insoluble. When water is added, the polymeric matrix is solubilized and enzyme is released from the matrix, permitting catalytic action upon the substrate.

    摘要翻译： 本发明提供包括酶/底物共递送系统的方法，组合物，系统和试剂盒。 液体递送系统包括至少一种包封在水溶性聚合物基质中的酶和在其中聚合物基质不溶性的载体液体中的酶的底物。 当加入水时，聚合物基体溶解，酶从基质中释放出来，允许对基底进行催化作用。