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    Granule containing protein and corn starch layered on an inert particle
    1.
    发明授权
    Granule containing protein and corn starch layered on an inert particle 有权
    含有蛋白质和玉米淀粉的颗粒层叠在惰性颗粒上

    公开(公告)号：US06413749B1

    公开(公告)日：2002-07-02

    申请号：US09428153

    申请日：1999-10-27

    申请人： Nathaniel T. Becker ,  Thomas S. Green

    发明人： Nathaniel T. Becker ,  Thomas S. Green

    IPC分类号： C12N998

    CPC分类号： C12N9/98 ,  Y10S530/812 ,  Y10S530/813

    摘要： Granules are prepared containing an admixture of protein and starch layered over an inert particle. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, lipases and cellulases capable of hydrolyzing substrates such as stains. Inert particles include inorganic salts, sugars, sugar alcohols, small organic molecules such as organic acids or salts, and minerals such as clays or silicates. The admixture may also contain sugar such as sucrose. A ratio of corn starch to sugar much greater than 1:1 such as in a range of about 5:1 to about 15:1 is preferred. A coating layer may be between the inert particle and the admixture and/or over the admixture. Methods that may be used in preparing the granules include pan-coating, fluid-bed coating, prilling, disc granulation, spray drying, extrusion, centrifugal extrusion, spheronization, drum granulation and high shear agglomeration.

    摘要翻译： 制备含有在惰性颗粒上分层的蛋白质和淀粉的混合物的颗粒。 蛋白质包括药学上重要的蛋白质，例如激素或工业上重要的蛋白质，例如酶，包括蛋白酶，淀粉酶，脂肪酶和能够水解底物如污渍的纤维素酶。 惰性颗粒包括无机盐，糖，糖醇，小有机分子如有机酸或盐，以及矿物质如粘土或硅酸盐。 该混合物还可以含有糖如蔗糖。 玉米淀粉与糖的比例大大高于1：1，例如在约5:1至约15:1的范围内。 涂层可以在惰性颗粒和混合物之间和/或混合物之间。 可用于制备颗粒的方法包括泛涂，流化床涂布，造粒，盘式造粒，喷雾干燥，挤出，离心挤出，滚圆，鼓式造粒和高剪切聚集。

    Granule containing enzyme, corn starch and sugar layered on an inert particle
    2.
    发明授权
    Granule containing enzyme, corn starch and sugar layered on an inert particle 有权
    含有颗粒的酶，玉米淀粉和糖分层在惰性颗粒上

    公开(公告)号：US06790643B2

    公开(公告)日：2004-09-14

    申请号：US10180785

    申请日：2002-06-25

    申请人： Nathaniel T. Becker ,  Thomas S. Green

    发明人： Nathaniel T. Becker ,  Thomas S. Green

    IPC分类号： C12N998

    CPC分类号： C12N9/98 ,  Y10S530/812 ,  Y10S530/813

    摘要： Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch and optionally sugar such as sucrose. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an enzyme or a therapeutic protein. A barrier layer may surround the protein core, and a coating can be applied to the seed particle, the protein matrix and/or the barrier layer.

    摘要翻译： 描述了包含蛋白质核心的颗粒。 蛋白质核心包括蛋白质基质，其包括与淀粉和任选的糖如蔗糖一起混合的蛋白质。 蛋白质基质可以分层在种子颗粒上，或蛋白质核心可以是均质的。 蛋白质可以是酶或治疗性蛋白质。 阻挡层可以围绕蛋白质核心，并且涂层可以施加到种子颗粒，蛋白质基质和/或阻挡层。

    Symmetrical fluidization coater for high capacity manufacturing
    7.
    发明授权
    Symmetrical fluidization coater for high capacity manufacturing 有权
    用于大容量制造的对称流化涂布机

    公开(公告)号：US06461672B1

    公开(公告)日：2002-10-08

    申请号：US09640394

    申请日：2000-08-16

    申请人： Antti Kosola ,  Ryszard Braun ,  Nathaniel T. Becker ,  Robert L. Christensen, Jr. ,  Ville Kyläkoski ,  Alfred L. Gaertner

    发明人： Antti Kosola ,  Ryszard Braun ,  Nathaniel T. Becker ,  Robert L. Christensen, Jr. ,  Ville Kyläkoski ,  Alfred L. Gaertner

    IPC分类号： B05D700

    CPC分类号： B01J2/16 ,  B01J2/006

    摘要： A fluidized bed coating apparatus is provided and includes a fluid inlet adapted to be connected to a source of fluidizing fluid. The fluid inlet has an entrance opening having a first diameter and an exit opening downstream of the entrance opening. The exit opening has a second diameter that is larger than the first diameter. The inlet also includes an expanding inlet section, between the entrance opening and the exit opening, that has an average diameter that increases in a direction from said entrance opening to said exit opening. A fluid distribution plate is provided adjacent the exit opening and includes a plurality of through-passages to allow the even and distributed passage of a fluidizing fluid therethrough. A chamber having a chamber inlet and a chamber outlet is provided and the fluid distribution plate is positioned between the exit opening and the chamber inlet. The chamber includes at least a first diverging section having an average diameter that increases in the direction from the chamber inlet downstream toward the chamber outlet. The symmetrical design of the coater provides an evenly distributed flow of fluid that enables efficient and complete fluidization and coating of very large particle beds.

    摘要翻译： 提供了一种流化床涂覆设备，并包括适于连接到流化流体源的流体入口。 流体入口具有入口，其具有第一直径和入口开口下游的出口。 出口具有大于第一直径的第二直径。 入口还包括在入口和出口之间的扩张入口部分，其具有在从所述入口到所述出口的方向上增加的平均直径。 流体分配板邻近出口设置并且包括多个通道以允许流化流体均匀分布通过其中。 提供具有室入口和室出口的室，并且流体分配板位于出口和室入口之间。 该腔室至少包括第一发散部分，该第一发散部分具有在从腔室入口下游朝向腔室出口的方向上增加的平均直径。 涂布机的对称设计提供均匀分布的流体流动，能够高效，完全地流化和涂覆非常大的颗粒床。

    Delivery system for co-formulated enzyme and substrate
    8.
    发明授权
    Delivery system for co-formulated enzyme and substrate 有权
    配制酶和底物的输送系统

    公开(公告)号：US08834865B2

    公开(公告)日：2014-09-16

    申请号：US13132069

    申请日：2009-11-03

    申请人： Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    发明人： Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    IPC分类号： A61K38/54 ,  C11D3/386 ,  C11D17/00

    CPC分类号： C11D17/0039 ,  C11D3/386 ,  C11D3/38672 ,  C11D3/38681

    摘要： The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a water-soluble polymeric matrix and a substrate for the enzyme in a carrier liquid in which the polymeric matrix is insoluble. When water is added, the polymeric matrix is solubilized and enzyme is released from the matrix, permitting catalytic action upon the substrate.

    摘要翻译： 本发明提供包括酶/底物共递送系统的方法，组合物，系统和试剂盒。 液体递送系统包括至少一种包封在水溶性聚合物基质中的酶和在其中聚合物基质不溶性的载体液体中的酶的底物。 当加入水时，聚合物基体溶解，酶从基质中释放出来，允许对基底进行催化作用。