公开(公告)号：US20120259315A1

公开(公告)日：2012-10-11

申请号：US13446400

申请日：2012-04-13

申请人： Neil HATTANGADI ,  Daniel LERNER ,  Ryan OLIVERA

发明人： Neil HATTANGADI ,  Daniel LERNER ,  Ryan OLIVERA

IPC分类号： A61M25/10 ,  A61L29/16

CPC分类号： A61M25/1011 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61M25/007 ,  A61M2025/1052

摘要： The present disclosure is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window.

摘要翻译： 本公开涉及用于将治疗剂的位点特异性递送给患者的血管的导管。 导管还包括细长轴，其具有至少一个内腔，远端和近端以及近端和远侧容器构造的气囊，其中每个气囊均可分开定位和充气，并且当充气时，基本上限制血管中的血流并产生 用于递送治疗剂的具有限定但可变长度的治疗窗。 导管可选地包括与近端球囊相邻的至少一个标记带和与远端球囊相邻的至少一个标记带。 定位在窗口中的至少一个侧向孔与位于内轴或外轴内的药物输送导管流体连通，以提供治疗剂到窗口的均匀浓度。