Pyrazolo[3,4-d]pyrimidine compounds
    9.
    发明授权
    Pyrazolo[3,4-d]pyrimidine compounds 有权
    吡唑并[3,4-d]嘧啶化合物

    公开(公告)号:US08637529B2

    公开(公告)日:2014-01-28

    申请号:US13157777

    申请日:2011-06-10

    CPC分类号: C07D487/04

    摘要: The present disclosure is directed to novel compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

    摘要翻译: 本公开涉及新的式(I)化合物,其药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量如本文所定义。 式(I)的化合物可用作激酶抑制剂,因此可用于治疗某些病症和疾病,特别是炎性病症和疾病以及增殖性疾病和病症,例如类风湿性关节炎,系统性红斑狼疮,多发性硬化症,克罗恩病 疾病,牛皮癣和哮喘。