Polymeric cannulae proteins, nucleic acids encoding them and methods for making and using them
    6.
    发明申请
    Polymeric cannulae proteins, nucleic acids encoding them and methods for making and using them 审中-公开
    聚合插管蛋白,编码它们的核酸以及制备和使用它们的方法

    公开(公告)号:US20050208121A1

    公开(公告)日:2005-09-22

    申请号:US11046203

    申请日:2005-01-28

    摘要: The invention provides chimeric cannulae polypeptides and methods for making and using them. In one aspect, the invention provides compositions and methods for the identification, separation or synthesis of proteins or ligands. In one aspect, the invention provides compositions and methods for making and using nanotubules. In one aspect, the invention provides compositions and methods for the selection and purification of chiral compositions from racemic mixtures. The invention provides compositions comprising polymers prepared by self-assembly of a plurality of monomeric polypeptide units, including nanorobots, biochips, drug delivery systems. In one aspect, the polymer can form a nanotube, and the polymer (nanotubule) can encapsulate a drug molecule—a drug delivery systems of the invention. A drug delivery system of the invention may be delivered to a particular location of human body to effectively cure a disease or treat a symptom. In one aspect, a targeting vector can be attached to a monomeric polypeptide unit or a polymer to facilitate the targeting of the drug delivery system of the invention.

    摘要翻译: 本发明提供了嵌合插管多肽及其制备和使用方法。 一方面,本发明提供用于鉴定,分离或合成蛋白质或配体的组合物和方法。 一方面,本发明提供了制备和使用纳米管的组合物和方法。 一方面,本发明提供了用于从外消旋混合物中选择和纯化手性组合物的组合物和方法。 本发明提供了包含通过自组装多个单体多肽单元制备的聚合物的组合物,包括纳米机器人,生物芯片,药物递送系统。 在一个方面,聚合物可以形成纳米管,并且聚合物(纳米管)可以包封药物分子 - 本发明的药物递送系统。 本发明的药物递送系统可以被递送到人体的特定位置以有效地治愈疾病或治疗症状。 在一个方面,靶向载体可以连接到单体多肽单元或聚合物以促进本发明的药物递送系统的靶向。

    Antibodies and methods for making and using them
    7.
    发明授权
    Antibodies and methods for making and using them 有权
    用于制造和使用它们的抗体和方法

    公开(公告)号:US08945550B2

    公开(公告)日:2015-02-03

    申请号:US12487422

    申请日:2009-06-18

    IPC分类号: A61K39/395

    摘要: The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic anti-bodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.

    摘要翻译: 本发明提供抗体,包括嵌合人抗体,重组抗体,合成抗体和编码它们的核酸,以及制备和使用这些免疫球蛋白的方法。 本发明提供这些多肽和/或抗体的重组和合成多肽和核酸实施方案。 本发明还提供了包含共有人框架区或“独立共有框架(ICF)”的编码它们的核酸或包含本发明的这些ICF和/或抗体的文库和试剂盒的多肽,并且组合的多肽 图书馆和组合。