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公开(公告)号：US06248756B1
公开(公告)日：2001-06-19
申请号：US09248883
申请日：1999-02-11
申请人： Neville J. Anthony , Christopher Dinsmore , Robert P. Gomez , John H. Hutchinson , John S. Wai , Theresa M. Williams , Ian M. Bell , Mark W. Embrey , Thorsten E. Fisher
发明人： Neville J. Anthony , Christopher Dinsmore , Robert P. Gomez , John H. Hutchinson , John S. Wai , Theresa M. Williams , Ian M. Bell , Mark W. Embrey , Thorsten E. Fisher
IPC分类号： A61K314468
CPC分类号： C07D401/06 , C07D211/62 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferas (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制法尼基蛋白转移（Fatease-protein transferas，FTase）和致癌基因蛋白Ras的法呢基化的化合物。 本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶的方法和癌基因蛋白Ras的法呢基化。
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公开(公告)号：US5939439A
公开(公告)日：1999-08-17
申请号：US995744
申请日：1997-12-22
申请人： Neville J. Anthony , Samuel L. Graham , Lekhanh O. Tran , Ian M. Bell , S. Jane deSolms , Robert P. Gomez , Michelle Sparks Kuo , William C. Lumma, Jr. , Debra S. Perlow , Anthony W. Shaw , John S. Wai , Steven D. Young
发明人： Neville J. Anthony , Samuel L. Graham , Lekhanh O. Tran , Ian M. Bell , S. Jane deSolms , Robert P. Gomez , Michelle Sparks Kuo , William C. Lumma, Jr. , Debra S. Perlow , Anthony W. Shaw , John S. Wai , Steven D. Young
IPC分类号： C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D417/14 , C07D471/04 , C07D401/04 , A61K31/44
CPC分类号： C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D417/14 , C07D471/04
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号：US07390798B2
公开(公告)日：2008-06-24
申请号：US11660798
申请日：2005-02-09
IPC分类号： C07D401/14 , C07D471/10 , A61K31/553 , A61K31/55 , A61K31/438 , A61K31/4166 , A61P25/06
CPC分类号： C07D471/04 , C07D401/12 , C07D413/12 , C07D519/00
摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved
摘要翻译： 本发明涉及式I的化合物：I（其中变量A 1，A 2，B，J，K，m，n，R 4 R 5c，R 5b和R 5c如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗 或预防CGRP所涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途
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公开(公告)号：US06410534B1
公开(公告)日：2002-06-25
申请号：US09347673
申请日：1999-06-29
IPC分类号： A61K314188
CPC分类号： C07D498/04 , A61K31/415 , A61K31/335 , A61K2300/00
摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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公开(公告)号：US07205293B2
公开(公告)日：2007-04-17
申请号：US10547228
申请日：2004-03-10
IPC分类号： C07D403/12 , A61K31/55 , A61P25/06
CPC分类号： C07D403/12 , C07D235/02
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07192954B2
公开(公告)日：2007-03-20
申请号：US10547082
申请日：2004-03-10
申请人： Ian M. Bell , Cory R. Theberge , Theresa M. Williams , C. Blair Zartman , Xu-Fang Zhang , Steven N. Gallicchio
发明人： Ian M. Bell , Cory R. Theberge , Theresa M. Williams , C. Blair Zartman , Xu-Fang Zhang , Steven N. Gallicchio
IPC分类号： A61K31/4439 , A61K31/422 , A61K31/551 , C07D413/02 , C07D243/04 , C07D401/14
CPC分类号： C07D235/02 , C07D401/14 , C07D403/12 , C07D413/12
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US06358985B1
公开(公告)日：2002-03-19
申请号：US09342577
申请日：1999-06-29
申请人： Neville J. Anthony , Ian M. Bell , Douglas C. Beshore , Terrence M. Ciccarone , S. Jane de Solms , Christopher J. Dinsmore , Gerald E. Stokker
发明人： Neville J. Anthony , Ian M. Bell , Douglas C. Beshore , Terrence M. Ciccarone , S. Jane de Solms , Christopher J. Dinsmore , Gerald E. Stokker
IPC分类号： A61K314164
CPC分类号： A61K31/4174 , A61K31/00
摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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公开(公告)号：US09409916B2
公开(公告)日：2016-08-09
申请号：US14005673
申请日：2012-03-14
申请人： Ian M. Bell , Justin Belardi
发明人： Ian M. Bell , Justin Belardi
IPC分类号： C07D487/10 , C07D471/10
CPC分类号： C07D487/10 , C07D471/10
摘要： The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮甲酰胺螺乙内酰脲衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20120122900A1
公开(公告)日：2012-05-17
申请号：US13293177
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/437 , A61K31/527 , A61P25/06 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US08143266B2
公开(公告)日：2012-03-27
申请号：US12595704
申请日：2008-04-11
申请人： Ian M. Bell , Harold G. Selnick , Craig A. Stump
发明人： Ian M. Bell , Harold G. Selnick , Craig A. Stump
IPC分类号： A61K31/437 , C07D221/20
CPC分类号： C07D471/20
摘要： Compounds of formula I: (wherein variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，B，m，n，J，X，R4，G1，G2，G3和Y如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或 预防CGRP涉及的疾病，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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