Benodiazepine spirohydantoin CGRP receptor antagonists
    4.
    发明授权
    Benodiazepine spirohydantoin CGRP receptor antagonists 有权
    苯妥英辛螺乙内酰脲CGRP受体拮抗剂

    公开(公告)号:US07205293B2

    公开(公告)日:2007-04-17

    申请号:US10547228

    申请日:2004-03-10

    CPC分类号: C07D403/12 C07D235/02

    摘要: The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译: 本发明涉及作为CGRP受体的拮抗剂的化合物,其可用于治疗或预防涉及CGRP的疾病,例如头痛,偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Piperidinone carboxamide spirohydantoin CGRP receptor antagonists
    5.
    发明授权
    Piperidinone carboxamide spirohydantoin CGRP receptor antagonists 有权
    哌啶酮甲酰胺螺乙内酰脲CGRP受体拮抗剂

    公开(公告)号:US09409916B2

    公开(公告)日:2016-08-09

    申请号:US14005673

    申请日:2012-03-14

    IPC分类号: C07D487/10 C07D471/10

    CPC分类号: C07D487/10 C07D471/10

    摘要: The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译: 本发明涉及作为CGRP受体的拮抗剂的哌啶酮甲酰胺螺乙内酰脲衍生物,其可用于治疗或预防涉及CGRP的疾病,例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Aryl heterocyclic CGRP receptor antagonists
    7.
    发明授权
    Aryl heterocyclic CGRP receptor antagonists 有权
    芳基杂环CGRP受体拮抗剂

    公开(公告)号:US08143266B2

    公开(公告)日:2012-03-27

    申请号:US12595704

    申请日:2008-04-11

    IPC分类号: A61K31/437 C07D221/20

    CPC分类号: C07D471/20

    摘要: Compounds of formula I: (wherein variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译: 式I化合物(其中变量A1,A2,B,m,n,J,X,R4,G1,G2,G3和Y如本文所述),其是CGRP受体的拮抗剂,其可用于治疗或 预防CGRP涉及的疾病,如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS
    8.
    发明申请
    BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS 审中-公开
    苯并噻唑化合物作为CGRP受体拮抗剂

    公开(公告)号:US20120065190A1

    公开(公告)日:2012-03-15

    申请号:US12520146

    申请日:2007-12-14

    摘要: Compounds of formula I: (wherein variables A1, m, R1, R2, R3, R4 and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译: 式I化合物(其中变量A1,m,R1,R2,R3,R4和Z如本文所述),其是CGRP受体的拮抗剂,其可用于治疗或预防涉及CGRP的疾病, 如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Spirolactam bicyclic CGRP receptor antagonists
    9.
    发明授权
    Spirolactam bicyclic CGRP receptor antagonists 有权
    螺内酰胺双环CGRP受体拮抗剂

    公开(公告)号:US08071772B2

    公开(公告)日:2011-12-06

    申请号:US12085131

    申请日:2006-11-14

    IPC分类号: C07D471/04

    CPC分类号: C07D471/20 C07D519/00

    摘要: Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2, J and K are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译: 式I化合物(其中变量A1,A2,A3,A4,A5,A6,A7,B,E1,E2,E3,E4,E5,G1,G2,J和K如本文所述) CGRP受体,其可用于治疗或预防涉及CGRP的疾病,例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。