专利检索 ap:("New York Blood Center, Inc.") AND inv:"Zhi Qi" 第 1 页

1.

发明授权
Stabilized trimeric HIV-1 GP41 fusion inhibitor polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif 有权

公开(公告)号：US09724383B2

公开(公告)日：2017-08-08

申请号：US14796725

申请日：2015-07-10

申请人： New York Blood Center, Inc.

发明人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan

IPC分类号： C07K14/05 , A61K38/16 , C07K14/005 , C12N7/00 , A61K38/00

CPC分类号： A61K38/162 , A61K38/00 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2740/16022 , C12N2740/16033 , C12N2740/16111 , C12N2740/16122

摘要： Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.