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公开(公告)号:US20150272093A1
公开(公告)日:2015-10-01
申请号:US14673334
申请日:2015-03-30
申请人: New York University
发明人: Greg Seong-Bae Suh , Monica Dus
IPC分类号: A01K67/033 , C07K14/435
CPC分类号: A01K67/0339 , A01K2207/15 , A01K2207/25 , A01K2217/052 , A01K2227/706 , A01K2267/03 , C07K14/43581
摘要: Provided is a gene in drosophila designated as dSLC5A1. This gene is responsible for taste independent nutrient sensing. Activation of neurons expressing this gene results in hunger behavior. Provided are compositions and methods for identifying agents that can interfere with hunger behavior.
摘要翻译: 提供的命名为dSLC5A1的果蝇中的基因。 该基因负责味道独立的营养感知。 激活表达该基因的神经元导致饥饿行为。 提供了用于鉴定可能干扰饥饿行为的药剂的组合物和方法。
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公开(公告)号:US20150231276A1
公开(公告)日:2015-08-20
申请号:US14624208
申请日:2015-02-17
申请人: New York University
发明人: Greg Seong-Bae Suh , Monica Dus
IPC分类号: A61K49/00
CPC分类号: A61K49/0008 , A01K67/0275 , A01K67/0339 , A01K2207/15 , A01K2207/25 , A01K2217/206 , A01K2227/105 , A01K2227/70
摘要: Provided are methods for identifying Drosophila melanogaster mutants which have mutations affecting calorie sensing behavior. Also provided are methods for identifying agents that can interfere with calorie sensing behavior in D. melanogaster and in mammals. Also provided are methods to identify agents that affect neuronal response of Dh44 neurons or CRF neurons to metabolizing sugars.
摘要翻译: 提供了用于鉴定具有影响卡路里感测行为的突变的果蝇黑腹果蝇突变体的方法。 还提供了用于鉴定可以干扰黑腹果蝇和哺乳动物中的热量感测行为的试剂的方法。 还提供了鉴定影响Dh44神经元或CRF神经元代谢糖的神经元反应的试剂的方法。
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公开(公告)号:US09717222B2
公开(公告)日:2017-08-01
申请号:US14673334
申请日:2015-03-30
申请人: New York University
发明人: Greg Seong-Bae Suh , Monica Dus
IPC分类号: G01N33/00 , A01K67/033 , C07K14/435
CPC分类号: A01K67/0339 , A01K2207/15 , A01K2207/25 , A01K2217/052 , A01K2227/706 , A01K2267/03 , C07K14/43581
摘要: Provided is a gene in drosophila designated as dSLC5A1. This gene is responsible for taste independent nutrient sensing. Activation of neurons expressing this gene results in hunger behavior. Provided are compositions and methods for identifying agents that can interfere with hunger behavior.
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