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1.SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权
标题翻译: 作为组胺H3受体的调节剂的替代吡咯烷公开(公告)号:US20090291903A1
公开(公告)日:2009-11-26
申请号:US12468632
申请日:2009-05-19
申请人: Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
发明人: Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC分类号: A61K38/05 , C07D403/06 , A61K31/551
CPC分类号: C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译: 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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2.Substituted pyrrolidine amides as modulators of the histamine H3 receptor 有权
标题翻译: 取代的吡咯烷酰胺作为组胺H3受体的调节剂公开(公告)号:US08236792B2
公开(公告)日:2012-08-07
申请号:US12468632
申请日:2009-05-19
申请人: Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
发明人: Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC分类号: A61K31/55 , A61K31/497 , A61K31/445 , A61K31/40 , C07D243/08 , C07D403/00 , C07D401/00 , C07D205/00
CPC分类号: C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译: 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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3.SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权
标题翻译: 作为组胺H3受体的调节剂的取代的吡啶酰胺化合物公开(公告)号:US20070281923A1
公开(公告)日:2007-12-06
申请号:US11753607
申请日:2007-05-25
申请人: John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人: John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号: A61K31/551 , A61K31/496 , C07D403/02
CPC分类号: C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译: 某些取代的吡啶酰胺化合物是可用于治疗组胺H 3受体介导的疾病的组胺H 3 N 3受体调节剂。
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4.SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权
标题翻译: 作为组胺H3受体的调节剂的取代的吡啶酰胺化合物公开(公告)号:US20100267701A1
公开(公告)日:2010-10-21
申请号:US12828883
申请日:2010-07-01
申请人: John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人: John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号: A61K31/551 , A61K31/496 , C07D403/14 , C07D403/12 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/24 , A61P25/06 , A61P25/08 , A61P27/02 , A61P25/30 , A61P25/20 , A61P25/00
CPC分类号: C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译: 某些取代的吡啶酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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5.Substituted pyridyl amide compounds as modulators of the histamine H3 receptor 有权
标题翻译: 取代的吡啶酰胺化合物作为组胺H3受体的调节剂公开(公告)号:US08637520B2
公开(公告)日:2014-01-28
申请号:US12828883
申请日:2010-07-01
申请人: John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人: John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号: A61K31/496 , C07D401/06
CPC分类号: C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译: 某些取代的吡啶酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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6.Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives 有权
标题翻译: 苯并咪唑-2-基嘧啶衍生物的制备方法公开(公告)号:US08835633B2
公开(公告)日:2014-09-16
申请号:US13427767
申请日:2012-03-22
申请人: Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人: Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号: C07D401/14 , C07D403/04
CPC分类号: C07D403/04
摘要: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译: 本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。
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7.Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives 审中-公开
标题翻译: 苯并咪唑-2-基嘧啶衍生物的制备方法公开(公告)号:US20120184740A1
公开(公告)日:2012-07-19
申请号:US13427798
申请日:2012-03-22
申请人: Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人: Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号: C07D401/14
CPC分类号: C07D403/04
摘要: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译: 本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。
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公开(公告)号:US08748596B2
公开(公告)日:2014-06-10
申请号:US13257224
申请日:2010-03-17
申请人: Diego Broggini , Vit Lellek , Susanne Lochner , Neelakandha S. Mani , Adrian Maurer , Daniel J. Pippel , Lana K. Young
发明人: Diego Broggini , Vit Lellek , Susanne Lochner , Neelakandha S. Mani , Adrian Maurer , Daniel J. Pippel , Lana K. Young
IPC分类号: C07D401/02 , C07D401/14
CPC分类号: C07D213/82 , C07B2200/13 , C07D405/12
摘要: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
摘要翻译: 本发明涉及用于制备组胺H3受体调节剂在治疗例如认知障碍,睡眠障碍和/或精神疾病中的新方法。
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公开(公告)号:US20120259130A1
公开(公告)日:2012-10-11
申请号:US13526995
申请日:2012-06-19
申请人: Luigi Anzalone , Daniel J. Pippel , Neelakandha S. Mani , Penina Feibush , IIias K. Dorziotis , Stefan Horns , Frank J. Villani, JR.
发明人: Luigi Anzalone , Daniel J. Pippel , Neelakandha S. Mani , Penina Feibush , IIias K. Dorziotis , Stefan Horns , Frank J. Villani, JR.
IPC分类号: C07F9/6553
CPC分类号: C07F9/655354 , C07F9/301 , C07F9/3808 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/6541 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/657181
摘要: The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds.
摘要翻译: 本发明涉及一种用于合成膦酸和次膦酸糜酶抑制剂化合物的改进方法。
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10.Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives 审中-公开
标题翻译: 苯并咪唑-2-基嘧啶衍生物的制备方法公开(公告)号:US20100029942A1
公开(公告)日:2010-02-04
申请号:US12459224
申请日:2009-06-29
申请人: Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人: Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号: C07D401/14
CPC分类号: C07D403/04
摘要: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译: 本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。
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