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公开(公告)号:US06713645B1
公开(公告)日:2004-03-30
申请号:US09688106
申请日:2000-10-13
申请人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号: C07C6976
CPC分类号: C07D409/04 , C07D209/88 , C07F9/5728
摘要: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译: 公开了一类新型三环类药物,以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号:US06177440B1
公开(公告)日:2001-01-23
申请号:US09063066
申请日:1998-04-21
申请人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号: A61K3144
CPC分类号: C07D209/88
摘要: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译: 公开了一类新型三环类药物,以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号:US06916840B2
公开(公告)日:2005-07-12
申请号:US10450860
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
IPC分类号: A61K31/404 , A61P29/00 , A61P43/00 , C07D209/12 , C07D209/60 , A61K31/40 , C07D209/56
CPC分类号: C07D209/60
摘要: A novel class of benz[g]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新颖的苯并[g]吲哚化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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公开(公告)号:US06992100B2
公开(公告)日:2006-01-31
申请号:US10450745
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
IPC分类号: A61K31/403 , C07D209/56
CPC分类号: A61K31/403 , A61K31/407 , A61K31/4745
摘要: A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新的四环化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克的用途。
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公开(公告)号:US06872743B2
公开(公告)日:2005-03-29
申请号:US10450633
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
IPC分类号: A61K31/403 , A61P1/00 , A61P1/18 , A61P7/00 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/80 , C07D209/94 , C07D209/56
CPC分类号: C07D209/80 , C07D209/94
摘要: A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 由式I代表的新一类四环化合物,其中R1,R2,R3,R4,R5,R6,R7,A,B,C,D,E和n定义同上, 抑制sPLA2介导的脂肪酸释放治疗炎症性疾病如脓毒性休克。
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公开(公告)号:US06251921B1
公开(公告)日:2001-06-26
申请号:US09312593
申请日:1999-05-14
申请人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号: A61K314436
CPC分类号: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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公开(公告)号:US6025382A
公开(公告)日:2000-02-15
申请号:US846647
申请日:1997-04-30
申请人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号: C07D295/08 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/02 , C07D333/56 , C07D333/58 , C07D333/62 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D521/00 , A61K31/40 , A61K31/38 , C07D409/14
CPC分类号: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译: 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂,凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物,其制备方法和中间体,以及包含式I化合物的药物制剂。
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公开(公告)号:US06974831B2
公开(公告)日:2005-12-13
申请号:US10450741
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
IPC分类号: A61K31/403 , A61P1/00 , A61P1/18 , A61P11/02 , A61P11/06 , A61P11/08 , A61P17/02 , A61P19/02 , A61P29/00 , A61P31/04 , A61P43/00 , C07D209/60 , C07D209/70 , C07D409/10 , A61K31/404 , C07D209/56
CPC分类号: C07D209/70 , C07D209/60 , C07D409/10
摘要: A novel class of cycloalkyl fused indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新型的环烷基稠合吲哚化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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公开(公告)号:US06930123B2
公开(公告)日:2005-08-16
申请号:US10450929
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
IPC分类号: A61K31/403 , A61P1/04 , A61P3/00 , A61P3/12 , A61P5/06 , A61P5/18 , A61P7/00 , A61P7/04 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/08 , A61P21/00 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/08 , A61P43/00 , C07D209/60 , A61K31/40 , C07D209/56
CPC分类号: C07D209/60
摘要: A novel class of benz[f]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新颖的苯并[f]吲哚化合物以及这些化合物用于抑制脂肪酸介导的释放脂肪酸用于治疗炎性疾病如败血性休克的用途。
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公开(公告)号:US06391908B1
公开(公告)日:2002-05-21
申请号:US09856942
申请日:2001-05-30
申请人: Nicholas James Bach , Richard Waltz Harper , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett
发明人: Nicholas James Bach , Richard Waltz Harper , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett
IPC分类号: A61K31404
CPC分类号: C07D209/22
摘要: A class of novel oxime indoles is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.
摘要翻译: 公开了一类新型肟吲哚以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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