Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use
    5.
    发明申请
    Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use 有权
    氨基杂芳基化合物作为β-分泌酶调节剂和使用方法

    公开(公告)号:US20130018064A1

    公开(公告)日:2013-01-17

    申请号:US13511360

    申请日:2010-11-19

    摘要: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病(包括阿尔茨海默病(AD))和相关病症的新一类化合物。 在一个实施方案中,化合物具有通式I,其中式I的环A,B 1,B 2,B 3,L,R 1,R 4,环Z,m和p如本文所定义。 本发明还包括在药物组合物中用于治疗,预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这些疾病包括例如阿尔茨海默氏病(AD),认知缺陷,认知障碍,精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案,可用于制备式I化合物的中间体和方法。

    Amino heteroaryl compounds as beta-secretase modulators and methods of use
    6.
    发明授权
    Amino heteroaryl compounds as beta-secretase modulators and methods of use 有权
    氨基杂芳基化合物作为β-分泌酶调节剂和使用方法

    公开(公告)号:US08822485B2

    公开(公告)日:2014-09-02

    申请号:US13511360

    申请日:2010-11-19

    IPC分类号: A61K31/505

    摘要: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病(包括阿尔茨海默病(AD))和相关病症的新一类化合物。 在一个实施方案中,化合物具有通式I,其中式I的环A,B 1,B 2,B 3,L,R 1,R 4,环Z,m和p如本文所定义。 本发明还包括在药物组合物中用于治疗,预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这些疾病包括例如阿尔茨海默氏病(AD),认知缺陷,认知障碍,精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案,可用于制备式I化合物的中间体和方法。