Cyclic amidines useful as NMDA NR2B antagonists
    5.
    发明授权
    Cyclic amidines useful as NMDA NR2B antagonists 失效
    作为NMDA NR2B拮抗剂有用的环脒

    公开(公告)号:US06376530B1

    公开(公告)日:2002-04-23

    申请号:US09550972

    申请日:2000-04-17

    IPC分类号: C07D20944

    摘要: The invention encompasses novel compounds of Formula I as well as a method of treating NMDA mediated diseases comprising administration to a patient in need of such treatment a non-toxic amount of a compound of Formula I effective to block the NMDA NR2B receptor sub-unit. The invention also encompasses certain pharmaceutical compositions for the treatment of NMDA mediated diseases comprising compounds of Formula I and a pharmaceutically acceptable carrier.

    摘要翻译: 本发明包括式I的新化合物以及治疗NMDA介导的疾病的方法,包括向需要这种治疗的患者施用无毒量的有效阻断NMDA NR2B受体亚单位的式I化合物。 本发明还包括用于治疗包含式I化合物和药学上可接受的载体的NMDA介导的疾病的某些药物组合物。