公开(公告)号：US06274716B1

公开(公告)日：2001-08-14

申请号：US09394044

申请日：1999-09-13

申请人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

发明人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

IPC分类号： C07H500

CPC分类号： C07H15/04 ,  C07H15/203 ,  C40B40/00

摘要： A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P-R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D-A moiety is in turn covalently linked through the anomeric carbon of A to the P-R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P-R groups used in assembling the compounds. Members of the library are preferably synthesized by solid phase techniques involving stepwise coupling of the respective units to a support, functionalizing the A and/or D saccharides either before or after immobilizing them on the support, and cleaving the assembled compounds from the support. Preferred functionalities attached to the sugar residues are amides, carbamates, ureas, sulfonamides, substituted amines, esters, carbonates, and sulfates. Exemplary P-R groups are derivatives of homoserine, glyceric acid, salicylates and mandelic acid. Members of the library can be screened for anti-microbial activity by contacting them with a culture of microbes and monitoring the growth rate of the microbes.

公开(公告)号：US06114309A

公开(公告)日：2000-09-05

申请号：US975229

申请日：1997-11-21

申请人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

发明人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

IPC分类号： C12Q1/02 ,  A61K31/7016 ,  A61K31/702 ,  A61P31/04 ,  C07B61/00 ,  C07H1/02 ,  C07H5/08 ,  C07H11/04 ,  C07H15/04 ,  C07H15/203 ,  A61K31/70 ,  C07H13/00

CPC分类号： C07H15/04 ,  C07H15/203 ,  C40B40/00

摘要： A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula ##STR1## wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P-R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D-A moiety is in turn covalently linked through the anomeric carbon of A to the P-R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P-R groups used in assembling the compounds. Members of the library are preferably synthesized by solid phase techniques involving stepwise coupling of the respective units to a support, functionalizing the A and/or D saccharides either before or after immobilizing them on the support, and cleaving the assembled compounds from the support. Preferred functionalities attached to the sugar residues are amides, carbamates, ureas, sulfonamides, substituted amines, esters, carbonates, and sulfates. Exemplary P-R groups are derivatives of homoserine, glyceric acid, salicylates and mandelic acid. Members of the library can be screened for anti-microbial activity by contacting them with a culture of microbes and monitoring the growth rate of the microbes.

摘要翻译： 结构上与新霉素类抗生素相关的化合物的组合化学文库具有下式：其中D是供体单糖或二糖，A是受体单糖，P-R是脂磷酸甘油酸酯模拟组。 文库成员在D的异头碳和A的C2碳之间具有糖苷键，D-A部分又通过A的端基异碳共价连接到P-R基团。 关于在A残基的C3位置发生的取代，在D残基的C2位置的取代以及用于组装化合物的不同的P-R基团，图书馆的成员表现出最大的结构多样性。 文库的成员优选通过固相技术合成，其包括将各单元逐步偶联到载体上，在将它们固定在载体上之前或之后将A和/或D糖功能化，并将载体化合物从载体上分离。 附着于糖残基的优选功能是酰胺，氨基甲酸酯，脲，磺酰胺，取代的胺，酯，碳酸酯和硫酸酯。 示例性的P-R基团是高丝氨酸，甘油酸，水杨酸盐和扁桃酸的衍生物。 通过与微生物培养物接触并监测微生物的生长速率，可以筛选图书馆成员的抗菌活性。

公开(公告)号：US06207820B1

公开(公告)日：2001-03-27

申请号：US09394045

申请日：1999-09-13

申请人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

发明人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

IPC分类号： C07H100

CPC分类号： C07H15/04 ,  C07H15/203 ,  C40B40/00

摘要： A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P—R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D—A moiety is in turn covalently linked through the anomeric carbon of A to the P—R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P—R groups used in assembling the compounds. Members of the library are preferably synthesized by solid phase techniques involving stepwise coupling of the respective units to a support, functionalizing the A and/or D saccharides either before or after immobilizing them on the support, and cleaving the assembled compounds from the support. Preferred functionalities attached to the sugar residues are amides, carbamates, ureas, sulfonamides, substituted amines, esters, carbonates, and sulfates. Exemplary P—R groups are derivatives of homoserine, glyceric acid, salicylates and mandelic acid. Members of the library can be screened for anti-microbial activity by contacting them with a culture of microbes and monitoring the growth rate of the microbes.

摘要翻译： 结构上与霉酚霉素类抗生素有关的化合物的组合化学文库，其中D是供体单糖或二糖，A是受体单糖，P-R是脂磷酸甘油酸酯模拟组。 文库成员在D的异头碳和A的C2碳之间具有糖苷键，D-A部分又通过A的端基异碳共价连接到P-R基团。 关于在A残基的C3位置发生的取代，在D残基的C2位置的取代以及用于组装化合物的不同的P-R基团，图书馆的成员表现出最大的结构多样性。 文库的成员优选通过固相技术合成，其包括将各单元逐步偶联到载体上，在将它们固定在载体上之前或之后将A和/或D糖功能化，并将载体化合物从载体上分离。 附着于糖残基的优选功能是酰胺，氨基甲酸酯，脲，磺酰胺，取代的胺，酯，碳酸酯和硫酸酯。 示例性的P-R基团是高丝氨酸，甘油酸，水杨酸盐和扁桃酸的衍生物。 通过与微生物培养物接触并监测微生物的生长速率，可以筛选图书馆成员的抗菌活性。

公开(公告)号：US20120151500A1

公开(公告)日：2012-06-14

申请号：US12967770

申请日：2010-12-14

申请人： Yiu-Ming Leung ,  Rui Liang ,  Yu Shao ,  Marcelo Farjalla ,  Li Zhang ,  Danilo Perez Solano ,  Sergei Osobov

发明人： Yiu-Ming Leung ,  Rui Liang ,  Yu Shao ,  Marcelo Farjalla ,  Li Zhang ,  Danilo Perez Solano ,  Sergei Osobov

IPC分类号： G06F13/00 ,  G06F9/46

CPC分类号： G06Q50/01 ,  G06Q10/10

摘要： Software applications are enabled with multimodal communication capabilities and features associated with enhanced communication systems through a communication application programming interface (API). Applications for document processing, scheduling, audio/video data processing, and/or business operations can exchange communication system data and parameters bi-directionally with components of an enhanced communication system, initiate communication sessions through the application's user interface, and preserve post-communication updates.

摘要翻译： 通过通信应用编程接口（API），软件应用程序启用了多模式通信功能和与增强型通信系统相关联的功能。 用于文档处理，调度，音频/视频数据处理和/或业务操作的应用可以与增强型通信系统的组件双向地交换通信系统数据和参数，通过应用的用户界面发起通信会话，并保留后通信 更新。

公开(公告)号：US07412496B2

公开(公告)日：2008-08-12

申请号：US10645976

申请日：2003-08-22

申请人： Stephen A Fridella ,  Gang Ma ,  Xiaoye Jiang ,  Sorin Faibish ,  Rui Liang

发明人： Stephen A Fridella ,  Gang Ma ,  Xiaoye Jiang ,  Sorin Faibish ,  Rui Liang

IPC分类号： G06F15/16 ,  G06F15/173

CPC分类号： G06F17/30067

摘要： To permit multiple unsynchronized processors to update the file-modification time attribute of a file during concurrent asynchronous writes to the file, a primary processor having a clock manages access to metadata of the file. A number of secondary processors service client request for access to the file. Each secondary processor has a timer. When the primary processor grants a range lock upon the file to a secondary, it returns its clock time (m). Upon receipt, the secondary starts a local timer (t). When the secondary modifies the file data, it determines a file-modification time that is a function of the clock time and the timer interval, such as a sum (m+t). When the secondary receives an updated file-modification time (mp) from the primary, if mp>m+t, then the secondary updates the clock time (m) to (mp) and resets its local timer.

摘要翻译： 为了允许多个不同步处理器在并发异步写入文件期间更新文件的文件修改时间属性，具有时钟的主处理器管理对文件的元数据的访问。 一些次要处理器服务客户端请求访问该文件。 每个二级处理器都有一个定时器。 当主处理器向文件夹授予范围锁定时，它返回其时钟时间（m）。 收到后，辅助启动本地计时器（t）。 当二次修改文件数据时，它确定作为时钟时间和定时器间隔的函数的文件修改时间，例如和（m + t）。 当辅助节点从主节点接收到更新的文件修改时间（mp）时，如果mp> m + t，则辅助节点将时钟（m）更新为（mp），并重置其本地定时器。

公开(公告)号：US20070211452A1

公开(公告)日：2007-09-13

申请号：US11369392

申请日：2006-03-07

申请人： Paul Gaunce ,  Rui Liang

发明人： Paul Gaunce ,  Rui Liang

IPC分类号： F21V33/00

CPC分类号： A47G1/02

摘要： A wall-mountable mirror support unit including at least one box having a rear face attachable to a wall is provided. A light permeable cover extends over and seals the front of the box to prevent the ingress of water or dirt therein. The box contains at least one light and associated circuitry therein. The support unit includes means to enable a mirror having light-permeable regions to be attached thereto over the front of the box so that the light emitted by each light is transmitted through the light permeable cover and the light permeable regions of the mirror.

摘要翻译： 提供一种壁挂式镜支撑单元，其包括至少一个具有可附接到壁的后表面的盒。 透光盖子延伸并密封箱体的前部，以防止其中的水或污物进入。 盒子中至少包含一个光和相关电路。 支撑单元包括能够使具有透光区域的反射镜在箱体的前部附接到其上的装置，使得由每个光发射的光透射通过透光罩和反射镜的透光区域。

公开(公告)号：US20070072924A1

公开(公告)日：2007-03-29

申请号：US11601252

申请日：2006-11-17

申请人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

发明人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

IPC分类号： A61K31/416 ,  C07D403/04

CPC分类号： C07D491/04 ,  C07D403/04 ,  C07D495/04

摘要： The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

摘要翻译： 本发明涉及式（I）的某些四唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病 ，综合征-X等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

公开(公告)号：US20060064405A1

公开(公告)日：2006-03-23

申请号：US10945611

申请日：2004-09-21

申请人： Xiaoye Jiang ,  Uday Gupta ,  Sorin Faibish ,  Rui Liang

发明人： Xiaoye Jiang ,  Uday Gupta ,  Sorin Faibish ,  Rui Liang

IPC分类号： G06F17/30

CPC分类号： H04L67/1097 ,  G06F16/10

摘要： A network file server has storage for storing a file system, and a computer programmed for access to the file system in accordance with a file access protocol and in accordance with a storage access protocol. The computer receives a file access request from a network client for access to a file in the file system in accordance with the network file access protocol. The computer decides whether it should finish the file access using the file access protocol or the client should finish the file access using the storage access protocol. Upon deciding that the client should finish the file access using the storage access protocol, the computer returns to the client metadata of the file including metadata specifying addresses of logical blocks of storage allocated to the file, and then the computer responds to storage access requests from the client by performing read-write access to the file.

摘要翻译： 网络文件服务器具有用于存储文件系统的存储器和被编程为根据文件访问协议和根据存储访问协议访问文件系统的计算机。 计算机根据网络文件访问协议从网络客户端接收文件访问请求，以访问文件系统中的文件。 计算机决定是否使用文件访问协议完成文件访问，或客户端应使用存储访问协议完成文件访问。 在确定客户端应该使用存储访问协议完成文件访问时，计算机返回文件的客户端元数据，包括指定分配给文件的逻辑存储块的地址的元数据，然后计算机响应来自 客户端通过对文件执行读写访问。

公开(公告)号：US06766418B1

公开(公告)日：2004-07-20

申请号：US09845385

申请日：2001-04-30

申请人： Jeffrey L. Alexander ,  Paul M. Bober ,  Rui Liang

发明人： Jeffrey L. Alexander ,  Paul M. Bober ,  Rui Liang

IPC分类号： G06F1200

CPC分类号： G06F17/30067

摘要： Mechanisms and techniques disclose a system that provides access to data using a two part cache. The system receives a data access request containing a first data reference, such as an open systems request to access data. The system then obtains a history cache entry from a history cache based on the first data reference and obtains a partition cache entry from a partition cache based on the first data reference. Cache entries contain mappings between open systems reference locations and non-open systems references to locations in the data to be accessed. The system then performs a data access operation as specified by the data access request using a second data reference based upon either the history cache entry or the partition cache entry. Upon performance of the data access operation, the system then updates the history and partition caches with new cache entries and can resize the partition and history caches as needed.

摘要翻译： 机制和技术公开了一种使用两部分高速缓存提供数据访问的系统。 系统接收包含第一数据引用的数据访问请求，诸如访问数据的开放系统请求。 然后，系统基于第一数据引用从历史高速缓存中获取历史高速缓存条目，并且基于第一数据引用从分区高速缓存获取分区高速缓存条目。 缓存条目包含打开的系统引用位置和非开放系统之间的对应关系要访问的数据中的位置。 然后，系统基于历史高速缓存条目或分区高速缓存条目，使用第二数据引用执行数据访问请求所指定的数据访问操作。 在执行数据访问操作时，系统随后使用新的缓存条目来更新历史记录和分区高速缓存，并且可以根据需要调整分区和历史缓存的大小。

公开(公告)号：US08436015B2

公开(公告)日：2013-05-07

申请号：US13063820

申请日：2009-09-10

申请人： Songnian Lin ,  Christian P. Stevenson ,  Emma R. Parmee ,  Libo Xu ,  Xibin Liao ,  Edward Metzger ,  Rui Liang ,  Fengqi Zhang ,  John E. Stelmach

发明人： Songnian Lin ,  Christian P. Stevenson ,  Emma R. Parmee ,  Libo Xu ,  Xibin Liao ,  Edward Metzger ,  Rui Liang ,  Fengqi Zhang ,  John E. Stelmach

IPC分类号： A01N43/42 ,  A61K31/47 ,  C07D215/00

CPC分类号： C07D215/18 ,  C07D215/227 ,  C07D217/22 ,  C07D217/24 ,  C07D239/70 ,  C07D403/04 ,  C07D413/04

摘要： Glucagon receptor antagonist compounds of formula I are disclosed: The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

摘要翻译： 公开了式I的胰高血糖素受体拮抗剂化合物：该化合物可用于治疗2型糖尿病和相关病症。 还包括药物组合物和治疗方法。