Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
    1.
    发明授权
    Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof 失效
    阿仑膦酸钠的水合物形式,其制备方法及其药物组合物

    公开(公告)号:US06281381B1

    公开(公告)日:2001-08-28

    申请号:US09384145

    申请日:1999-08-27

    IPC分类号: C07F938

    CPC分类号: C07F9/3873

    摘要: New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.

    摘要翻译: 公开了水含量为约1至约12%的阿仑膦酸钠的新水合物形式及其制备方法。 还公开了阿仑膦酸钠B,D,E,F,G和H的新结晶形式及其制备方法。 这些新形式的阿仑膦酸钠适于掺入用于对抗骨疾病中的骨吸收的药物组合物中。

    Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
    2.
    发明授权
    Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof 失效
    阿仑膦酸钠的水合物形式,其制备方法及其药物组合物

    公开(公告)号:US06963008B2

    公开(公告)日:2005-11-08

    申请号:US10751237

    申请日:2003-12-31

    IPC分类号: C07F9/38 C07C9/38

    CPC分类号: C07F9/3873

    摘要: New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.

    摘要翻译: 公开了水含量为约1至约12%的阿仑膦酸钠的新水合物形式及其制备方法。 还公开了阿仑膦酸钠B,D,E,F,G和H的新结晶形式及其制备方法。 这些新形式的阿仑膦酸钠适于掺入用于对抗骨疾病中的骨吸收的药物组合物中。

    Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
    3.
    发明授权
    Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof 失效
    阿仑膦酸钠的水合物形式,其制备方法及其药物组合物

    公开(公告)号:US06696601B2

    公开(公告)日:2004-02-24

    申请号:US09898756

    申请日:2001-07-03

    IPC分类号: C07F900

    CPC分类号: C07F9/3873

    摘要: New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.

    摘要翻译: 公开了水含量为约1至约12%的阿仑膦酸钠的新水合物形式及其制备方法。 还公开了阿仑膦酸钠B,D,E,F,G和H的新结晶形式及其制备方法。 这些新形式的阿仑膦酸钠适于掺入用于对抗骨疾病中的骨吸收的药物组合物中。