公开(公告)号：US08524868B2

公开(公告)日：2013-09-03

申请号：US12614896

申请日：2009-11-09

申请人： Ningshao Xia ,  Jun Zhang ,  Shaowei Li ,  Shengxiang Ge ,  Ying Gu ,  Zhiqiang He

发明人： Ningshao Xia ,  Jun Zhang ,  Shaowei Li ,  Shengxiang Ge ,  Ying Gu ,  Zhiqiang He

IPC分类号： C12P21/08 ,  A61K39/29

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6075 ,  C07K16/10 ,  C07K2319/00 ,  C12N2760/16022 ,  C12N2770/28122 ,  C12N2770/28134 ,  C12N2770/28171 ,  G01N33/576

摘要： The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric polypeptide, wherein n is an integer from 1-180; to a chimeric protein consisting of a polypeptide of the present invention and a conserved fragment of hemagglutin antigen from influenza virus; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3 or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention. The present invention further relates to a vaccine composition against hepatitis E virus which comprises the above-mentioned polypeptide, or diagnostic kit for hepatitis E virus infection comprising the above-mentioned polypeptide, which includes IgG, IgM, or total antibody diagnostic kit for hepatitis E virus, and to the use of vaccine composition and diagnostic kit for prophylaxis, diagnosis and/or treatment of hepatitis E virus infection.

摘要翻译： 本发明涉及多肽，其包含戊型肝炎病毒ORF 2的SEQ ID No.1所示的氨基酸序列或其片段，其为n-聚合多肽形式，其中n为 1-180; 涉及由本发明的多肽和来自流感病毒的血凝素抗原的保守片段组成的嵌合蛋白; 涉及与来自戊型肝炎病毒ORF3或其免疫原性片段的含有多肽的表位结合的本发明的多肽; 涉及包含编码上述多肽的DNA分子和能够表达本发明多肽的所述重组表达载体转化的宿主细胞的重组表达载体。 本发明还涉及一种抗艾滋病毒病毒的疫苗组合物，其包含上述多肽或用于戊型肝炎病毒感染的诊断试剂盒，其包含上述多肽，其包括用于戊型肝炎的IgG，IgM或总抗体诊断试剂盒 病毒，以及使用疫苗组合物和诊断试剂盒进行戊型肝炎病毒感染的预防，诊断和/或治疗。

公开(公告)号：US08715695B2

公开(公告)日：2014-05-06

申请号：US12557741

申请日：2009-09-11

申请人： Ningshao Xia ,  Jun Zhang ,  Shaowei Li ,  Shengxiang Ge ,  Ying Gu ,  Zhiqiang He

发明人： Ningshao Xia ,  Jun Zhang ,  Shaowei Li ,  Shengxiang Ge ,  Ying Gu ,  Zhiqiang He

IPC分类号： A61K39/29

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6075 ,  C07K16/10 ,  C07K2319/00 ,  C12N2760/16022 ,  C12N2770/28122 ,  C12N2770/28134 ,  C12N2770/28171 ,  G01N33/576

摘要： The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric polypeptide, wherein n is an integer from 1-180; to a chimeric protein consisting of a polypeptide of the present invention and a conserved fragment of hemagglutin antigen from influenza virus; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3 or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention. The present invention further relates to a vaccine composition against hepatitis E virus which comprises the above-mentioned polypeptide, or diagnostic kit for hepatitis E virus infection comprising the above-mentioned polypeptide, which includes IgG, IgM, or total antibody diagnostic kit for hepatitis E virus, and to the use of vaccine composition and diagnostic kit for prophylaxis, diagnosis and/or treatment of hepatitis E virus infection.

摘要翻译： 本发明涉及多肽，其包含戊型肝炎病毒ORF 2的SEQ ID No.1所示的氨基酸序列或其片段，其为n-聚合多肽形式，其中n为 1-180; 涉及由本发明的多肽和来自流感病毒的血凝素抗原的保守片段组成的嵌合蛋白; 涉及与来自戊型肝炎病毒ORF3或其免疫原性片段的含有多肽的表位结合的本发明的多肽; 涉及包含编码上述多肽的DNA分子和能够表达本发明多肽的所述重组表达载体转化的宿主细胞的重组表达载体。 本发明还涉及一种抗艾滋病毒病毒的疫苗组合物，其包含上述多肽或用于戊型肝炎病毒感染的诊断试剂盒，其包含上述多肽，其包括用于戊型肝炎的IgG，IgM或总抗体诊断试剂盒 病毒，以及使用疫苗组合物和诊断试剂盒进行戊型肝炎病毒感染的预防，诊断和/或治疗。

公开(公告)号：US07786264B2

公开(公告)日：2010-08-31

申请号：US10495091

申请日：2002-11-08

申请人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

发明人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

IPC分类号： C12P21/08 ,  C17K16/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K16/10 ,  C12N2770/28122 ,  C12N2770/28134 ,  G01N33/576

摘要： The present invention relates to monoclonal antibody specifically binding to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its conserved variants or its active fragments, or other monoclonal antibodies against ORF2 which can cross react with said monoclonal antibody of present invention, and its nucleotide sequence or its degenerate sequence; to the antigenic determinant in hepatitis E virus ORF2; to a method for screening isolated or recombined polypeptide or polypeptide analog, which has the same property of specifically binding said monoclonal antibody 8C11 and/or 8H3 as said antigenic determinant 1) or 3) of hepatitis E virus ORF2; to polypeptide or polypeptide analog screened by the method above and its nucleotide sequence or degenerate sequence; to a use of said polypeptide or polypeptide analog in preparation of a medicament for the diagnosis and/or precaution of hepatitis E virus infection; to a diagnostic kit for hepatitis E virus infection and a vaccine composition for prophylaxis of hepatitis E virus infection; to use of said monoclonal antibodies or their active fragments or conserved variants in preparation of a medicament for diagnosis, prophylaxis and/or treatment of hepatitis E virus infection; to pharmaceutical composition for prophylaxis and/or treatment of hepatitis E virus infection and a method for prophylaxis and/or treatment of hepatitis E virus infection; to a recombinant expression vector comprising said nucleotide molecule in present invention and a host cell transformed with said recombinant expression vector that is able to express monoclonal antibody and its conserved variants or active fragments or polypeptide or polypeptide analogs.

摘要翻译： 本发明涉及特异性结合多肽的单克隆抗体，其包含如戊型肝炎病毒ORF 2的SEQ ID No.1所示的氨基酸序列或其保守变体或其活性片段或针对ORF2的其它单克隆抗体， 可以与本发明的所述单克隆抗体交叉反应，其核苷酸序列或其简并序列; 对乙型肝炎病毒ORF2的抗原决定簇; 涉及用于筛选分离或重组的多肽或多肽类似物的方法，其具有与所述单克隆抗体8C11和/或8H3特异性结合作为所述抗原决定簇1）或3）的戊型肝炎病毒ORF2的相同性质; 通过上述方法筛选的多肽或多肽模拟物及其核苷酸序列或简并序列; 涉及所述多肽或多肽类似物在制备用于诊断和/或预防戊型肝炎病毒感染的药物中的用途; 用于戊型肝炎病毒感染的诊断试剂盒和用于预防戊型肝炎病毒感染的疫苗组合物; 在制备用于诊断，预防和/或治疗戊型肝炎病毒感染的药物中使用所述单克隆抗体或其活性片段或保守变体; 用于预防和/或治疗戊型肝炎病毒感染的药物组合物和预防和/或治疗戊型肝炎病毒感染的方法; 涉及包含本发明中的所述核苷酸分子和能够表达单克隆抗体及其保守变体或活性片段或多肽或多肽类似物的所述重组表达载体转化的宿主细胞的重组表达载体。

公开(公告)号：US20100003281A1

公开(公告)日：2010-01-07

申请号：US12433497

申请日：2009-04-30

申请人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

发明人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

IPC分类号： A61K39/29 ,  C07K14/00 ,  C07K7/08 ,  C07H21/00 ,  G01N33/53 ,  C07K2/00 ,  C12Q1/70 ,  A61K38/02 ,  C12N15/63 ,  C12N1/00 ,  A61P31/12

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K16/10 ,  C12N2770/28122 ,  C12N2770/28134 ,  G01N33/576

摘要： The present invention relates to monoclonal antibody specifically binding to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF2 or its conserved variants or its active fragments, or other monoclonal antibodies against ORF2 which can cross react with said monoclonal antibody of present invention, and its nucleotide sequence or its degenerate sequence; to the antigenic determinant in hepatitis E virus ORF2; to a method for screening isolated or recombined polypeptide or polypeptide analog, which has the same property of specifically binding said monoclonal antibody 8C11 and/or 8H3 as said antigenic determinant 1) or 3) of hepatitis E virus ORF2; to polypeptide or polypeptide analog screened by the method above and its nucleotide sequence or degenerate sequence; to a use of said polypeptide or polypeptide analog in preparation of a medicament for the diagnosis and/or precaution of hepatitis E virus infection; to a diagnostic kit for hepatitis E virus infection and a vaccine composition for prophylaxis of hepatitis E virus infection; to use of said monoclonal antibodies or their active fragments or conserved variants in preparation of a medicament for diagnosis, prophylaxis and/or treatment of hepatitis E virus infection; to pharmaceutical composition for prophylaxis and/or treatment of hepatitis E virus infection and a method for prophylaxis and/or treatment of hepatitis E virus infection; to a recombinant expression vector comprising said nucleotide molecule in present invention and a host cell transformed with said recombinant expression vector that is able to express monoclonal antibody and its conserved variants or active fragments or polypeptide or polypeptide analogs.

摘要翻译： 本发明涉及与多肽特异性结合的单克隆抗体，其包含如戊型肝炎病毒ORF2的SEQ ID No.1所示的氨基酸序列或其保守变体或其活性片段或针对ORF2的其它单克隆抗体，其可以 与本发明的单克隆抗体交叉反应，其核苷酸序列或其简并序列; 对乙型肝炎病毒ORF2的抗原决定簇; 涉及用于筛选分离或重组的多肽或多肽类似物的方法，其具有与所述单克隆抗体8C11和/或8H3特异性结合作为所述抗原决定簇1）或3）的戊型肝炎病毒ORF2的相同性质; 通过上述方法筛选的多肽或多肽模拟物及其核苷酸序列或简并序列; 涉及所述多肽或多肽类似物在制备用于诊断和/或预防戊型肝炎病毒感染的药物中的用途; 用于戊型肝炎病毒感染的诊断试剂盒和用于预防戊型肝炎病毒感染的疫苗组合物; 在制备用于诊断，预防和/或治疗戊型肝炎病毒感染的药物中使用所述单克隆抗体或其活性片段或保守变体; 用于预防和/或治疗戊型肝炎病毒感染的药物组合物和预防和/或治疗戊型肝炎病毒感染的方法; 涉及包含本发明中的所述核苷酸分子和能够表达单克隆抗体及其保守变体或活性片段或多肽或多肽类似物的所述重组表达载体转化的宿主细胞的重组表达载体。

公开(公告)号：US09428554B2

公开(公告)日：2016-08-30

申请号：US12433497

申请日：2009-04-30

申请人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

发明人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

IPC分类号： C07K14/005 ,  A61K39/29 ,  C07K16/10 ,  A61K39/00 ,  G01N33/576 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K16/10 ,  C12N2770/28122 ,  C12N2770/28134 ,  G01N33/576

摘要： The present invention relates to monoclonal antibody specifically binding to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF2 or its conserved variants or its active fragments, or other monoclonal antibodies against ORF2 which can cross react with said monoclonal antibody of present invention, and its nucleotide sequence or its degenerate sequence; to the antigenic determinant in hepatitis E virus ORF2; to a method for screening isolated or recombined polypeptide or polypeptide analog, which has the same property of specifically binding said monoclonal antibody 8C11 and/or 8H3 as said antigenic determinant 1) or 3) of hepatitis E virus ORF2; to polypeptide or polypeptide analog screened by the method above and its nucleotide sequence or degenerate sequence; to a use of said polypeptide or polypeptide analog in preparation of a medicament for the diagnosis and/or precaution of hepatitis E virus infection; to a diagnostic kit for hepatitis E virus infection and a vaccine composition for prophylaxis of hepatitis E virus infection; to use of said monoclonal antibodies or their active fragments or conserved variants in preparation of a medicament for diagnosis, prophylaxis and/or treatment of hepatitis E virus infection; to pharmaceutical composition for prophylaxis and/or treatment of hepatitis E virus infection and a method for prophylaxis and/or treatment of hepatitis E virus infection; to a recombinant expression vector comprising said nucleotide molecule in present invention and a host cell transformed with said recombinant expression vector that is able to express monoclonal antibody and its conserved variants or active fragments or polypeptide or polypeptide analogs.

摘要翻译： 本发明涉及与多肽特异性结合的单克隆抗体，其包含如戊型肝炎病毒ORF2的SEQ ID No.1所示的氨基酸序列或其保守变体或其活性片段或针对ORF2的其它单克隆抗体，其可以 与本发明的单克隆抗体交叉反应，其核苷酸序列或其简并序列; 对乙型肝炎病毒ORF2的抗原决定簇; 涉及用于筛选分离或重组的多肽或多肽类似物的方法，其具有与所述单克隆抗体8C11和/或8H3特异性结合作为所述抗原决定簇1）或3）的戊型肝炎病毒ORF2的相同性质; 通过上述方法筛选的多肽或多肽模拟物及其核苷酸序列或简并序列; 涉及所述多肽或多肽类似物在制备用于诊断和/或预防戊型肝炎病毒感染的药物中的用途; 用于戊型肝炎病毒感染的诊断试剂盒和用于预防戊型肝炎病毒感染的疫苗组合物; 在制备用于诊断，预防和/或治疗戊型肝炎病毒感染的药物中使用所述单克隆抗体或其活性片段或保守变体; 用于预防和/或治疗戊型肝炎病毒感染的药物组合物和预防和/或治疗戊型肝炎病毒感染的方法; 涉及包含本发明中的所述核苷酸分子和能够表达单克隆抗体及其保守变体或活性片段或多肽或多肽类似物的所述重组表达载体转化的宿主细胞的重组表达载体。

公开(公告)号：US07615228B2

公开(公告)日：2009-11-10

申请号：US10381770

申请日：2001-09-30

申请人： Ningshao Xia ,  Jun Zhang ,  Shaowei Li ,  Shengxiang Ge ,  Ying Gu ,  Zhiqiang He

发明人： Ningshao Xia ,  Jun Zhang ,  Shaowei Li ,  Shengxiang Ge ,  Ying Gu ,  Zhiqiang He

IPC分类号： A61K39/29

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6075 ,  C07K16/10 ,  C07K2319/00 ,  C12N2760/16022 ,  C12N2770/28122 ,  C12N2770/28134 ,  C12N2770/28171 ,  G01N33/576

摘要： A purified polypeptide comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of a polymer with n monomeric polypeptides, wherein n is an integer from 2-180; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention. The present invention further relates to a vaccine composition against hepatitis E virus which comprises the above-mentioned polypeptide, or diagnostic kit for hepatitis E virus infection comprising the above-mentioned polypeptide, which includes IgG, IgM, or total antibody diagnostic kit for hepatitis E virus, and to the use of vaccine composition and diagnostic kit for prophylaxis, diagnosis and/or treatment of hepatitis E virus infection.

摘要翻译： 一种纯化的多肽，其包含戊型肝炎病毒ORF 2的SEQ ID No.1所示的氨基酸序列或其片段，其为具有n个单体多肽的聚合物形式，其中n为2-180的整数; 涉及与来自戊型肝炎病毒ORF3的含多肽表位结合的本发明的多肽或其免疫原性片段; 涉及包含编码上述多肽的DNA分子和能够表达本发明多肽的所述重组表达载体转化的宿主细胞的重组表达载体。 本发明还涉及一种抗艾滋病毒病毒的疫苗组合物，其包含上述多肽或用于戊型肝炎病毒感染的诊断试剂盒，其包含上述多肽，其包括用于戊型肝炎的IgG，IgM或总抗体诊断试剂盒 病毒，以及使用疫苗组合物和诊断试剂盒进行戊型肝炎病毒感染的预防，诊断和/或治疗。

公开(公告)号：US20060233822A1

公开(公告)日：2006-10-19

申请号：US10495091

申请日：2002-11-08

申请人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

发明人： Ningshao Xia ,  Jun Zhang ,  Ying Gu ,  Shaowei Li ,  Shengxiang Ge ,  Zhiqiang He

IPC分类号： C12Q1/70 ,  C07H21/04 ,  C12P21/06 ,  A61K39/29 ,  C12N15/86 ,  C07K14/02 ,  C07K16/08

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K16/10 ,  C12N2770/28122 ,  C12N2770/28134 ,  G01N33/576

摘要： The present invention relates to monoclonal antibody specifically binding to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its conserved variants or its active fragments, or other monoclonal antibodies against ORF2 which can cross react with said monoclonal antibody of present invention, and its nucleotide sequence or its degenerate sequence; to the antigenic determinant in hepatitis E virus ORF2; to a method for screening isolated or recombined polypeptide or polypeptide analog, which has the same property of specifically binding said monoclonal antibody 8C11 and/or 8H3 as said antigenic determinant 1) or 3) of hepatitis E virus ORF2; to polypeptide or polypeptide analog screened by the method above and its nucleotide sequence or degenerate sequence; to a use of said polypeptide or polypeptide analog in preparation of a medicament for the diagnosis and/or precaution of hepatitis E virus infection; to a diagnostic kit for hepatitis E virus infection and a vaccine composition for prophylaxis of hepatitis E virus infection; to use of said monoclonal antibodies or their active fragments or conserved variants in preparation of a medicament for diagnosis, prophylaxis and/or treatment of hepatitis E virus infection; to pharmaceutical composition for prophylaxis and/or treatment of hepatitis E virus infection and a method for prophylaxis and/or treatment of hepatitis E virus infection; to a recombinant expression vector comprising said nucleotide molecule in present invention and a host cell transformed with said recombinant expression vector that is able to express monoclonal antibody and its conserved variants or active fragments or polypeptide or polypeptide analogs.

摘要翻译： 本发明涉及特异性结合多肽的单克隆抗体，其包含如戊型肝炎病毒ORF 2的SEQ ID No.1所示的氨基酸序列或其保守变体或其活性片段或针对ORF2的其它单克隆抗体， 可以与本发明的所述单克隆抗体交叉反应，其核苷酸序列或其简并序列; 对乙型肝炎病毒ORF2的抗原决定簇; 涉及用于筛选分离或重组的多肽或多肽类似物的方法，其具有与所述单克隆抗体8C11和/或8H3特异性结合作为所述抗原决定簇1）或3）的戊型肝炎病毒ORF2的相同性质; 通过上述方法筛选的多肽或多肽模拟物及其核苷酸序列或简并序列; 涉及所述多肽或多肽类似物在制备用于诊断和/或预防戊型肝炎病毒感染的药物中的用途; 用于戊型肝炎病毒感染的诊断试剂盒和用于预防戊型肝炎病毒感染的疫苗组合物; 在制备用于诊断，预防和/或治疗戊型肝炎病毒感染的药物中使用所述单克隆抗体或其活性片段或保守变体; 用于预防和/或治疗戊型肝炎病毒感染的药物组合物和预防和/或治疗戊型肝炎病毒感染的方法; 涉及包含本发明中的所述核苷酸分子和能够表达单克隆抗体及其保守变体或活性片段或多肽或多肽类似物的所述重组表达载体转化的宿主细胞的重组表达载体。

公开(公告)号：US20090068637A1

公开(公告)日：2009-03-12

申请号：US12162343

申请日：2007-01-26

申请人： Ningshao Xia ,  Yixin Chen ,  Shengxiang Ge ,  Wenxin Luo ,  Jun Zhang

发明人： Ningshao Xia ,  Yixin Chen ,  Shengxiang Ge ,  Wenxin Luo ,  Jun Zhang

IPC分类号： C12Q1/70 ,  C07K16/08 ,  C12M1/34 ,  C07H21/04

CPC分类号： C07K16/1018 ,  A61K47/646 ,  A61K47/6901 ,  B82Y15/00 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

摘要： The present application provides monoclonal antibodies that specifically bind to the hemagglutinin of avian influenza virus subtype H5, as well as monoclonal antibodies capable of blocking at least 50% of the hemagglutinin binding activity of these monoclonal antibodies. Such antibodies are useful, for example, in the detection, diagnosis, prevention, and treatment of avian influenza virus. Also provided herein are hybridoma cell lines, isolated nucleic acid molecules, and short peptides related to the monoclonal antibodies provided herein, and pharmaceutical compositions and kits containing the monoclonal antibodies provided herein.

摘要翻译： 本申请提供了特异性结合禽流感病毒亚型H5的血凝素的单克隆抗体，以及能够阻断这些单克隆抗体的至少50％血凝素结合活性的单克隆抗体。 这样的抗体可用于例如禽流感病毒的检测，诊断，预防和治疗。 本文还提供杂交瘤细胞系，分离的核酸分子和与本文提供的单克隆抗体相关的短肽，以及含有本文提供的单克隆抗体的药物组合物和试剂盒。