-
公开(公告)号:US20050272647A1
公开(公告)日:2005-12-08
申请号:US10525015
申请日:2003-08-19
申请人: Noboru Yamaji , Nobuaki Shindou , Yoh Terada
发明人: Noboru Yamaji , Nobuaki Shindou , Yoh Terada
IPC分类号: A61K31/00 , A61K31/16 , A61K31/167 , A61K31/19 , A61K31/4045 , A61K31/4406 , A61K38/15 , A61P19/02 , A61P43/00 , A61K38/12
CPC分类号: A61K31/4406 , A61K31/00 , A61K31/16 , A61K31/167 , A61K31/19 , A61K31/4045 , A61K38/15
摘要: An agent for inhibiting articular cartilage extracellular matrix degradation of the present invention, comprising a histone deacetylase-inhibiting compound as an active ingredient, is effective for the prevention and treatment of diseases and pathological conditions involving the degradation and degeneration of the articular cartilage extracellular matrix, in particular, arthrosteitis, rheumatic arthritis, osteoarthritis, and the like.
摘要翻译: 包含组蛋白脱乙酰酶抑制化合物作为活性成分的本发明抑制关节软骨细胞外基质降解的药剂对于预防和治疗涉及关节软骨细胞外基质降解和变性的疾病和病理状况是有效的, 特别是关节炎,风湿性关节炎,骨关节炎等。
-
公开(公告)号:US07585886B2
公开(公告)日:2009-09-08
申请号:US11662539
申请日:2006-05-18
申请人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
发明人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
IPC分类号: C07D207/00 , A61K31/40
CPC分类号: C07D207/09 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/06 , C07D417/10
摘要: [Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism. [Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like).
摘要翻译: [问题]提供可用于治疗其中涉及钙感觉受体(CaSR)的疾病的化合物,特别是甲状旁腺机能亢进。 [解决方法]发现以芳基烷基等取代的氨甲基为特征的新型吡咯烷衍生物或其盐具有优异的CaSR激动调节活性,并且对于CYP2D6抑制活性也具有优异的选择性,具有 引起药物相互作用的可能性。 基于上述,这些新型吡咯烷衍生物可用作治疗涉及CaSR的疾病(甲状旁腺功能亢进,肾性骨营养不良,高钙血症等)的治疗剂。
-
公开(公告)号:US20090062366A1
公开(公告)日:2009-03-05
申请号:US11662539
申请日:2006-05-18
申请人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
发明人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
IPC分类号: A61K31/40 , C07D207/04
CPC分类号: C07D207/09 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/06 , C07D417/10
摘要: [Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism.[Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like).
-
公开(公告)号:US07098186B2
公开(公告)日:2006-08-29
申请号:US10525717
申请日:2003-08-28
申请人: Koji Nagai , Masatoshi Taniguchi , Nobuaki Shindo , Yoh Terada , Masamichi Mori , Nobuaki Amino , Ken-ichi Suzumura , Isao Takahashi , Mitsuo Amase
发明人: Koji Nagai , Masatoshi Taniguchi , Nobuaki Shindo , Yoh Terada , Masamichi Mori , Nobuaki Amino , Ken-ichi Suzumura , Isao Takahashi , Mitsuo Amase
CPC分类号: C07K5/0205 , A61K38/00 , C07K11/00
摘要: The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an inhibitory activity of cell proliferation against human cancer cells and, therefore, is useful in treatment and improvement of diseases and pathogenic conditions associated with histone acetylation, in particular, tumor or cell proliferative diseases.
摘要翻译: 本发明涉及一种新型化合物,其可用作预防和治疗与HDAC相关疾病,特别是肿瘤或细胞增殖性疾病的药剂。 本发明的前肽化合物或其药学上可接受的盐具有良好的HDAC抑制活性和对人癌细胞的细胞增殖的抑制活性,因此可用于治疗和改善与组蛋白乙酰化有关的疾病和病原性病症 特别是肿瘤或细胞增殖性疾病。
-
公开(公告)号:US20100029687A1
公开(公告)日:2010-02-04
申请号:US12514869
申请日:2007-11-14
申请人: Shunichiro Hachiya , Kazuhiro Ikegai , Ryotaro Ibuka , Taisuke Takahashi , Makoto Oku , Ryushi Seo , Yoh Terada , Masanao Sanagi
发明人: Shunichiro Hachiya , Kazuhiro Ikegai , Ryotaro Ibuka , Taisuke Takahashi , Makoto Oku , Ryushi Seo , Yoh Terada , Masanao Sanagi
IPC分类号: A61K31/497 , C07D211/30 , C07D413/12 , C07D401/12 , A61K31/454 , A61K31/4545 , A61K31/445 , A61P5/18
CPC分类号: C07D211/26 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/06
摘要: [Problem] To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism.[Means for Resolution] It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomethyl group substituted with an arylalkyl group or the like and the other position is substituted with aryl, heteroaryl or the like, or a salt thereof, has an excellent CaSR agonistic regulatory action, and also has excellent selectivity with a CYP2D6 inhibitory action having a possibility of causing drug interaction. Based on the above, this novel piperidine derivative is useful as a therapeutic agent for diseases in which CaSR participates (hyperparathyroidism, renal osteodystrophy, hypercalcemia, and the like).
摘要翻译: [问题]提供可用于治疗钙感觉受体(CaSR)参与的疾病的化合物,特别是甲状旁腺功能亢进。 [解决方法]发现一种新的哌啶衍生物,其特征在于3-位和4-位中的一个被被芳基烷基等取代的氨基甲基取代,另一个位置被 芳基,杂芳基等,或其盐具有优异的CaSR激动调节作用,并且与具有引起药物相互作用的可能性的CYP2D6抑制作用也具有优异的选择性。 基于上述,该新型哌啶衍生物可用作CaSR参与的疾病(甲状旁腺功能亢进,肾性骨营养不良,高钙血症等)的治疗剂。
-
公开(公告)号:US08153658B2
公开(公告)日:2012-04-10
申请号:US12514869
申请日:2007-11-14
申请人: Shunichiro Hachiya , Kazuhiro Ikegai , Ryotaro Ibuka , Taisuke Takahashi , Makoto Oku , Ryushi Seo , Yoh Terada , Masanao Sanagi
发明人: Shunichiro Hachiya , Kazuhiro Ikegai , Ryotaro Ibuka , Taisuke Takahashi , Makoto Oku , Ryushi Seo , Yoh Terada , Masanao Sanagi
IPC分类号: A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , C07D409/12 , C07D405/04 , C07D413/04 , C07D411/04 , C07D401/04 , C07D401/12
CPC分类号: C07D211/26 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/06
摘要: To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism. It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomethyl group substituted with an arylalkyl group or the like and the other position is substituted with aryl, heteroaryl or the like, or a salt thereof, has an excellent CaSR agonistic regulatory action, and also has excellent selectivity with a CYP2D6 inhibitory action having a possibility of causing drug interaction. Based on the above, this novel piperidine derivative is useful as a therapeutic agent for diseases in which CaSR participates (hyperparathyroidism, renal osteodystrophy, hypercalcemia, and the like).
摘要翻译: 提供可用于治疗钙感觉受体(CaSR)参与的疾病的化合物,特别是甲状旁腺功能亢进。 发现新的哌啶衍生物,其特征在于3-位和4-位中的一个被被芳基烷基等取代的氨基甲基取代,另一个位置被芳基,杂芳基或 或其盐具有优异的CaSR激动调节作用,并且与具有引起药物相互作用的可能性的CYP2D6抑制作用也具有优异的选择性。 基于上述,该新型哌啶衍生物可用作CaSR参与的疾病(甲状旁腺功能亢进,肾性骨营养不良,高钙血症等)的治疗剂。
-
公开(公告)号:US20130029973A1
公开(公告)日:2013-01-31
申请号:US13639260
申请日:2011-04-27
申请人: Shunichiro Hachiya , Masanori Miura , Yoshimasa Imamura , Daisuke Kaga , Ippei Sato , Hiroyuki Moritomo , Koji Kato , Kazuhiro Terai , Yoh Terada
发明人: Shunichiro Hachiya , Masanori Miura , Yoshimasa Imamura , Daisuke Kaga , Ippei Sato , Hiroyuki Moritomo , Koji Kato , Kazuhiro Terai , Yoh Terada
IPC分类号: A61K31/381 , A61K31/5377 , A61K31/496 , A61K31/4535 , A61K31/444 , A61P7/00 , C07D409/12 , C07D413/14 , C07D413/12 , C07D409/14 , C07D333/66 , A61K31/55 , A61K31/4025
CPC分类号: C07D333/66 , A61K31/381 , A61K31/4025 , A61K31/4436 , A61K31/444 , A61K31/4535 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/63 , A61K31/7042 , C07D333/68 , C07D409/12
摘要: A compound has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating hyperphosphatemia, preventing hyperphosphatemia, or both. The compound is a tetrahydrobenzothiophene compound. A pharmaceutical composition for treating hyperphosphatemia includes the compound or salt thereof. A method of treating hyperphosphatemia includes administering to a subject an effective amount of the compound or salt thereof.
摘要翻译: 化合物具有肠道磷酸盐转运蛋白(NPT-IIb)抑制作用,可用作治疗高磷血症,预防高磷酸血症或二者的活性成分。 该化合物是四氢苯并噻吩化合物。 用于治疗高磷血症的药物组合物包括其化合物或其盐。 治疗高磷血症的方法包括给予受试者有效量的化合物或其盐。
-
公开(公告)号:US20050209134A1
公开(公告)日:2005-09-22
申请号:US10525717
申请日:2003-08-28
申请人: Koji Nagai , Masatoshi Taniguchi , Nobuaki Shindo , Yoh Terada , Masamichi Mori , Nobuaki Amino , Ken-ichi Suzumura , Isao Takahashi , Mitsuo Amase
发明人: Koji Nagai , Masatoshi Taniguchi , Nobuaki Shindo , Yoh Terada , Masamichi Mori , Nobuaki Amino , Ken-ichi Suzumura , Isao Takahashi , Mitsuo Amase
CPC分类号: C07K5/0205 , A61K38/00 , C07K11/00
摘要: The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an inhibitory activity of cell proliferation against human cancer cells and, therefore, is useful in treatment and improvement of diseases and pathogenic conditions associated with histone acetylation, in particular, tumor or cell proliferative diseases.
摘要翻译: 本发明涉及一种新型化合物,其可用作预防和治疗与HDAC相关疾病,特别是肿瘤或细胞增殖性疾病的药剂。 本发明的前肽化合物或其药学上可接受的盐具有良好的HDAC抑制活性和对人癌细胞的细胞增殖的抑制活性,因此可用于治疗和改善与组蛋白乙酰化有关的疾病和病原性病症 特别是肿瘤或细胞增殖性疾病。
-
-
-
-
-
-
-