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1.7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them 失效
标题翻译: 7-氮杂吲哚,它们作为磷酸二酯酶4的抑制剂的用途,以及它们的合成方法公开(公告)号:US07683074B2
公开(公告)日:2010-03-23
申请号:US12075312
申请日:2008-03-10
申请人: Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
发明人: Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
IPC分类号: A61K31/4745
CPC分类号: C07D471/04
摘要: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds and methods of treating arthritis and other conditions with the compounds are also provided.
摘要翻译: 7-氮杂吲哚抑制磷酸二酯酶4(PDE4)。 还提供了制备这些化合物的方法和用化合物治疗关节炎和其它病症的方法。
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2.7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them 失效
标题翻译: 7-氮杂吲哚,它们作为磷酸二酯酶4的抑制剂的用途,以及它们的合成方法公开(公告)号:US07419987B2
公开(公告)日:2008-09-02
申请号:US11329400
申请日:2006-01-10
申请人: Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
发明人: Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
IPC分类号: A61K31/4745
CPC分类号: C07D471/04
摘要: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds are also provided.
摘要翻译: 7-氮杂吲哚抑制磷酸二酯酶4(PDE4)。 还提供了制备这些化合物的方法。
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3.7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same 失效
标题翻译: 7-氮杂吲哚,其作为磷酸二酯酶4抑制剂的用途及其制备方法公开(公告)号:US07169787B2
公开(公告)日:2007-01-30
申请号:US10399051
申请日:2001-10-25
申请人: Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
发明人: Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
IPC分类号: A61K31/437 , A61K31/5377 , C07D295/02 , C07D221/04 , C07D221/02
CPC分类号: C07D471/04
摘要: The invention relates to new 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and to methods for their synthesis.
摘要翻译: 本发明涉及新的7-氮杂吲哚,它们用作磷酸二酯酶4的抑制剂及其合成方法。
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4.
公开(公告)号:US06602890B2
公开(公告)日:2003-08-05
申请号:US10081807
申请日:2002-02-21
申请人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号: C07D40106
CPC分类号: C07D209/22 , C07D209/24 , C07D401/12
摘要: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
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5.Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation 失效
标题翻译: 羟基吲哚,它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号:US06545158B2
公开(公告)日:2003-04-08
申请号:US10081395
申请日:2002-02-21
申请人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号: C07D40106
CPC分类号: C07D209/22 , C07D209/24 , C07D401/12
摘要: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译: 本发明涉及式的新型羟基吲哚,它们用作磷酸二酯酶4的抑制剂及其制备方法。
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6.Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation 失效
标题翻译: 羟基吲哚,它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号:US06545025B2
公开(公告)日:2003-04-08
申请号:US10080821
申请日:2002-02-21
申请人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号: A61K314439
CPC分类号: C07D209/22 , C07D209/24 , C07D401/12
摘要: The invention relates to nets hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译: 本发明涉及式的N-羟基吲哚,它们作为磷酸二酯酶4的抑制剂的用途及其制备方法。
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7.Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation 有权
标题翻译: 羟基吲哚,它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号:US06251923B1
公开(公告)日:2001-06-26
申请号:US09300973
申请日:1999-04-28
申请人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号: A61K314439
CPC分类号: C07D209/22 , C07D209/24 , C07D401/12
摘要: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译: 本发明涉及式的新型羟基吲哚,它们用作磷酸二酯酶4的抑制剂及其制备方法。
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8.Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation 失效
标题翻译: 羟基吲哚,它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号:US07161009B2
公开(公告)日:2007-01-09
申请号:US10081642
申请日:2002-02-21
申请人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号: C07D401/12
CPC分类号: C07D209/22 , C07D209/24 , C07D401/12
摘要: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译: 本发明涉及式的新型羟基吲哚,它们用作磷酸二酯酶4的抑制剂及其制备方法。
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9.
公开(公告)号:US06613794B2
公开(公告)日:2003-09-02
申请号:US10347659
申请日:2003-01-20
申请人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人: Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号: A61K31405
CPC分类号: C07D209/22 , C07D209/24 , C07D401/12
摘要: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
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10.
公开(公告)号:US06465465B1
公开(公告)日:2002-10-15
申请号:US09779925
申请日:2001-02-08
IPC分类号: A61K3150
CPC分类号: A61K31/4985
摘要: The invention relates to the use of pyrido[3,2-e]-pyrazinones of formula 1 as inhibitors of phosphodiesterase 5 for the treatment of erectile dysfunction (impotence).
摘要翻译: 本发明涉及式1的吡啶并[3,2-e] - 吡嗪酮用作磷酸二酯酶5的抑制剂用于治疗勃起功能障碍(阳ence)。
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