公开(公告)号：US4343953A

公开(公告)日：1982-08-10

申请号：US159497

申请日：1980-06-16

申请人： Noritada Matsuo ,  Nobushige Itaya ,  Kohichi Aketa ,  Osamu Magara ,  Toshio Nishioka

发明人： Noritada Matsuo ,  Nobushige Itaya ,  Kohichi Aketa ,  Osamu Magara ,  Toshio Nishioka

IPC分类号： C07C45/66 ,  C07C45/67 ,  C07C45/72 ,  C07C49/24 ,  C07C45/45

CPC分类号： C07C49/24 ,  C07C45/66 ,  C07C45/673 ,  C07C45/72

摘要： The present invention relates to a novel method for producing cyclopentenolone of the formula (I), ##STR1## which is a useful intermediate for producing agricultural chemicals, which comprises reacting an acetonedicarboxylic ester of the formula (VII), ##STR2## wherein R is a C.sub.1 -C.sub.6 alkyl group, with 2-propynyl chloride in the presence of magnesium alkoxide and in the presence of alkali iodide to obtain novel mono-(2-propynyl)-substituted acetonedicarboxylic ester of the formula (VI), ##STR3## wherein R is as defined above; hydrolyzing the mono-(2-propynyl)-substituted acetonedicarboxylic ester of the formula (VI) under alkaline conditions with an alkali and then reacting the hydrolyzed product with methylglyoxal of the formula, ##STR4## to obtain novel .gamma.-diketone of the formula (V), ##STR5## and ring-closing the .gamma.-diketone of the formula (V) under alkaline condition.

摘要翻译： 本发明涉及一种制备式（I）的环戊烯醇酮的新方法，其是用于生产农药的有用的中间体，其包括使式（VII）的丙酮二羧酸酯， （Ⅶ）其中R是C 1 -C 6烷基，与2-丙炔基氯在烷氧基镁存在下，在碱金属碘化物的存在下，得到式（Ⅵ）的新型单 - （2-丙炔基） - 取代的丙酮二羧酸酯 ），其中R如上定义; 在碱性条件下用碱水解式（Ⅵ）的单 - （2-丙炔基） - 取代的丙二酸二羧酸酯，然后使水解产物与下式的甲基乙二醛反应，得到式（Ⅵ）的新的γ-二酮 V），（V）并在碱性条件下闭合式（V）的γ-二酮。

公开(公告)号：US3981903A

公开(公告)日：1976-09-21

申请号：US491637

申请日：1974-07-25

申请人： Masachika Hirano ,  Isao Ohno ,  Yoshitoshi Okuno ,  Osamu Magara ,  Nobushige Itaya ,  Toshio Nishioka ,  Toshio Mizutani ,  Nobuo Ohno ,  Takashi Matsuo ,  Hisami Takeda

发明人： Masachika Hirano ,  Isao Ohno ,  Yoshitoshi Okuno ,  Osamu Magara ,  Nobushige Itaya ,  Toshio Nishioka ,  Toshio Mizutani ,  Nobuo Ohno ,  Takashi Matsuo ,  Hisami Takeda

IPC分类号： C07C69/747 ,  A01N53/02 ,  A01N53/06 ,  A01N53/10 ,  A01P7/04 ,  C07C69/743 ,  C07C69/74

CPC分类号： A01N53/00 ,  C07C69/743 ,  Y10S514/937 ,  Y10S514/953

摘要： A new pyrethroidal pesticide containing as an active ingredient a pesticidally effective amount of novel cyclopropanecarboxylic acid esters represented by the formula, ##EQU1## wherein R is a hydrogen atom, a halogen atom, a methyl or a methoxy group, and R.sub.1 and R.sub.2 are hydrogen atom, methyl group or a halogen atom, which have a low toxicity to mammals, excellent pesticidal effect on injurious pests in cereal storage, agriculture and forestry and a wide range of uses for prevention of epidemics.

摘要翻译： 一种新的拟除虫菊酯农药，其含有杀虫有效量的由式R 1表示的新型环丙烷羧酸酯作为活性成分，其中C = CH-CH-CH-CO-CH 2 C = C-CH 2 Cl平行|角度角OR2 CH3CH3，其中R是氢原子，卤素原子，甲基或甲氧基，R1和R2是对哺乳动物毒性低的氢原子，甲基或卤素原子，对谷物中有害害虫具有优良的杀虫作用 储存，农业和林业以及预防流行病的广泛用途。

公开(公告)号：US3932459A

公开(公告)日：1976-01-13

申请号：US491636

申请日：1974-07-25

申请人： Yoshitoshi Okuno ,  Masachika Hirano ,  Isao Ohno ,  Hisami Takeda ,  Osamu Magara ,  Nobushige Itaya ,  Toshio Nishioka ,  Toshio Mizutani ,  Nobuo Ohno ,  Takashi Matsuo

发明人： Yoshitoshi Okuno ,  Masachika Hirano ,  Isao Ohno ,  Hisami Takeda ,  Osamu Magara ,  Nobushige Itaya ,  Toshio Nishioka ,  Toshio Mizutani ,  Nobuo Ohno ,  Takashi Matsuo

IPC分类号： C07C69/747 ,  A01N53/04 ,  A01N53/06 ,  C07C67/00 ,  C07C253/00 ,  C07C255/39 ,  C07D307/45 ,  C07D307/56 ,  C07D317/54 ,  C07D333/16 ,  C07D333/24 ,  C07D333/78

CPC分类号： C07D333/16 ,  C07D333/78

摘要： A new cyclopropanecarboxylic acid ester represented by the formula, ##SPC1##Wherein R.sub.1 is alkyl having up to four carbon atoms, alkenyl having up to five carbon atoms, cycloalkenyl having up to six carbon atoms, alkenyl having up to five carbon atoms, benzyl, phenoxy or halogen; R.sub.2 and R.sub.3 are hydrogen, halogen or methyl; and any adjacent two of R.sub.1, R.sub.2 and R.sub.3 may combine to form polymethylene, which is useful as insecticides and acaricides having a strong insecticidal activity but a low toxicity to mammals, in agriculture, horticulture as well as public health.

摘要翻译： 由下式表示的新的环丙烷羧酸酯WHEREIN R1是具有至多4个碳原子的烷基，具有至多5个碳原子的烯基，具有至多6个碳原子的环烯基，具有至多5个碳原子的链烯基，苄基，苯氧基或卤素 ; R2和R3是氢，卤素或甲基; 并且R 1，R 2和R 3中的任何相邻的两个可以结合形成多亚甲基，其可用作具有强的杀虫活性但对哺乳动物毒性低，在农业，园艺以及公共卫生中的杀虫剂和杀螨剂。

公开(公告)号：US4008268A

公开(公告)日：1977-02-15

申请号：US585592

申请日：1975-06-10

申请人： Toshio Mizutani ,  Nobushige Itaya ,  Toshiko Nishijima ,  Osamu Magara

发明人： Toshio Mizutani ,  Nobushige Itaya ,  Toshiko Nishijima ,  Osamu Magara

IPC分类号： C07C61/40 ,  B01J27/00 ,  C07B61/00 ,  C07C51/00 ,  C07C51/353 ,  C07C67/00 ,  C07C61/18

CPC分类号： C07C51/353

摘要： A process for isomerizing 2-(.beta.,.beta.-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylic acid represented by the formula, ##STR1## which comprises heating the acid of the formula (I) in the presence of the anhydride of the acid or a reagent producing the acid anhydride in the reaction system.The ester resulting from 2-(.beta.,.beta.-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylic acid and, for example, 3-phenoxybenzyl alcohol is a compound which has a very wide range of insecticidal spectrum and has a very high controlling effect as a low-toxicity insecticide not only for domestic use and public health but also against insects injurious to agriculture or forestry, and in the case of the 3-phenoxybenzyl ester or 5-benzyl-3-furylmethyl ester of the 2-(.beta.,.beta.-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylic acid, the trans-isomer is lower than the cis-isomer in toxicity to warm-blooded animals.

摘要翻译： 异构化由式（I）表示的2-（β，β-二氯乙烯基）-3,3-二甲基环丙烷甲酸的方法，其包括在存在下述的酸酐的情况下加热式（I）的酸 酸或在反应体系中产生酸酐的试剂。

公开(公告)号：US4740612A

公开(公告)日：1988-04-26

申请号：US825966

申请日：1986-02-05

申请人： Takashi Matsuo ,  Nobushige Itaya ,  Osamu Magara

发明人： Takashi Matsuo ,  Nobushige Itaya ,  Osamu Magara

IPC分类号： C07C69/743 ,  A01N37/06 ,  A01P7/04 ,  C07C20060101 ,  C07C23/04 ,  C07C49/16 ,  C07C49/163 ,  C07C49/327 ,  C07C51/377 ,  C07C61/15 ,  C07C61/35 ,  C07C61/40 ,  C07C62/18 ,  C07C67/00 ,  C07C69/74 ,  C07C69/747 ,  C07C69/757

CPC分类号： C07C45/65 ,  C07C45/69

摘要： A novel process for producing a .beta.-dihalogenoethenylcyclopropane derivative of the formula, ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl group, R.sub.3 is a hydrogen atom, lower alkyl, acyl, carboxyl or alkoxycarbonyl group and R is a hydrogen atom or a lower alkyl group and each of Y.sub.1 and Y.sub.2 is a fluorine, chlorine or bromine atom respectively, which is an acidic moiety of the useful synthetic insecticides of the pyrethrin type, which process comprises a combination of a series of sequential steps starting from alkyl 3-butenyl ketone derivative of the formula (I), which may be shown according to the following reaction scheme: ##STR2## According to this process, objective compound of the formula (VI) having any cis/trans ratio can be produced by selecting the reaction condition of the Stages II-1, II-2, and IV-2.

摘要翻译： 一种制备下式的β-二卤代乙酰基环丙烷衍生物的新方法，其中R1是氢原子或烷基，R3是氢原子，低级烷基，酰基，羧基或烷氧基羰基，R是氢原子或 低级烷基，Y1和Y2各自分别是氟，氯或溴原子，它们是除虫菊酯类有用的合成杀虫剂的酸性部分，该方法包括从烷基3开始的一系列顺序步骤的组合 （VI）的目标化合物，其具有任何顺式（Ⅵ）的式（Ⅵ）的化合物， /反式比可以通过选择阶段II-1，II-2和IV-2的反应条件来产生。