-
公开(公告)号：US20050136108A1
公开(公告)日：2005-06-23
申请号：US10920934
申请日：2004-08-18
申请人： Noymi Yam , Padmaja Shivanand , Rhea Kimbel , Clark Allphin , Patrick Wong
发明人： Noymi Yam , Padmaja Shivanand , Rhea Kimbel , Clark Allphin , Patrick Wong
CPC分类号： A61K9/0004
摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form released from the dosage form as a dry or substantially dry erodible solid over a prolonged period of time at a stepwise increasing rate of release are described.
摘要翻译： 描述了以逐步增加的释放速率在长时间内作为干燥或基本上干燥的可侵蚀固体从剂型释放的控释剂型中的托吡酯增强分散的组合物和剂型。
-
公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
-
公开(公告)号：US20050175690A1
公开(公告)日：2005-08-11
申请号：US11024330
申请日：2004-12-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
发明人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
CPC分类号： A61K9/209 , A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
-
公开(公告)号：US20050175697A1
公开(公告)日：2005-08-11
申请号：US11024378
申请日：2004-12-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
发明人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
CPC分类号： A61K9/0004 , A61K9/209 , A61K31/35
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
-
公开(公告)号：US20060034927A1
公开(公告)日：2006-02-16
申请号：US11196556
申请日：2005-08-02
申请人： Gemma Casadevall , Ramkumar Subramanian , Brian Barclay , Clark Allphin , Padmaja Shivanand , Noymi Yam
发明人： Gemma Casadevall , Ramkumar Subramanian , Brian Barclay , Clark Allphin , Padmaja Shivanand , Noymi Yam
IPC分类号： A61K31/519 , A61K9/24
CPC分类号： A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/209 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K31/519
摘要： Disclosed are dosage forms and methods for sustained release of a drug including: a delay layer comprising a polymeric matrix, and microencapsulated drug, wherein the delay layer is substantially free of non-microencapsulated drug; and a second layer including a polymeric matrix, and non-microencapsulated drug matrix; wherein the second layer is located adjacent to the delay layer.
摘要翻译： 公开了用于药物持续释放的剂型和方法，包括：延迟层，其包含聚合物基质和微囊化药物，其中所述延迟层基本上不含非微胶囊化药物; 和包含聚合物基质和非微胶囊化药物基质的第二层; 其中所述第二层位于所述延迟层附近。
-
6.发明申请Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation 审中-公开通过增强的分散配方，长时间均匀地输送托吡酯公开(公告)号：US20050058707A1
公开(公告)日：2005-03-17
申请号：US10910040
申请日：2004-08-03
申请人： Iran Reyes , Noymi Yam , Padmaja Shivanand , Shaoling Li , Patrick Wong
发明人： Iran Reyes , Noymi Yam , Padmaja Shivanand , Shaoling Li , Patrick Wong
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2086 , A61K9/209 , A61K9/4866 , A61K31/35
摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form delivered as a dry or substantially dry erodible solid at a uniform rate over a prolonged period of time are described.
摘要翻译： 描述了用于增强托吡酯在控制释放剂型中的分散性的组合物和剂型，其作为干燥或基本上干燥的可侵蚀固体以均匀速率在延长的时间段内递送。
-
公开(公告)号：US06346270B1
公开(公告)日：2002-02-12
申请号：US09587686
申请日：2000-06-05
IPC分类号： A61K924
CPC分类号： A61K9/0004 , A61K31/4166
摘要： A therapeutic composition, a dosage form and a method are disclosed for administering phenytoin indicated for the management of epilepsy.
摘要翻译： 公开了治疗组合物，剂型和方法，用于施用用于治疗癫痫的苯妥英。
-
公开(公告)号：US20050238709A1
公开(公告)日：2005-10-27
申请号：US10639914
申请日：2003-08-12
申请人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
发明人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458 , A61K31/445
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
-
公开(公告)号：US06919373B1
公开(公告)日：2005-07-19
申请号：US09253317
申请日：1999-02-19
申请人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Richard G. Weyers , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Zahedeh Hatamkhany
发明人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Richard G. Weyers , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Zahedeh Hatamkhany
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458 , A61K31/235
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
-
公开(公告)号：US20050106249A1
公开(公告)日：2005-05-19
申请号：US10977403
申请日：2004-10-28
申请人： Stephen Hwang , Nishit Modi , Padmaja Shivanand
发明人： Stephen Hwang , Nishit Modi , Padmaja Shivanand
IPC分类号： A61K9/00 , A61K31/485 , A61K9/26
CPC分类号： A61K31/485 , A61K9/0004 , A61K2300/00
摘要： Oxycodone formulations are provided which produce substantially flat in vivo steady state plasma profiles. Tolerance levels associated with such profiles and tolerance levels associated with biphasic profiles are shown not to be statistically different. The substantially flat in vivo steady state plasma profiles are produced by dosage forms having substantially zero order in vitro release profiles. Such release profiles produce low single dose in vivo Cmax levels which can reduce the probability of adverse side effects.
摘要翻译： 提供氧可酮制剂，其产生基本上平坦的体内稳态血浆曲线。 与双相曲线相关的这种轮廓和公差水平相关联的公差水平显示为不具有统计学差异。 基本上平坦的体内稳态血浆曲线通过具有基本上为零次的体外释放曲线的剂型产生。 这种释放曲线产生较低的单剂量体内C max水平，这可以降低不良副作用的可能性。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.021 秒)