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    Devices for warming fluid and methods of use
    1.
    发明申请
    Devices for warming fluid and methods of use 失效
    加热液体的装置和使用方法

    公开(公告)号：US20020147481A1

    公开(公告)日：2002-10-10

    申请号：US09829670

    申请日：2001-04-09

    申请人： NxSTAGE MEDICAL, INC.

    发明人： James M. Brugger ,  Jeffrey H. Burbank ,  Dennis M. Treu

    IPC分类号： A61F007/00

    CPC分类号： A61F7/0085 ,  A61F2007/0054 ,  A61M5/44

    摘要： An external fluid warming device is described that includes a fluid warming chamber and an air separation chamber. The fluid warming chamber has a fluid inlet that communicates with a fluid pathway. The air separation chamber that communicates with the fluid pathway has a fluid outlet and a gas outlet. A heating source, such as heat plates, are disposed adjacent the fluid pathway for transferring heat to the fluid. In use, the air separation chamber is positioned above the fluid warming chamber and the heating source. The fluid inlet is connected to a source of fluid and the fluid outlet is connected to an output device, such as an ultrafiltration machine. Gas generated during warming of the fluid collects at a top of the air separation chamber and is vented through the gas outlet, whereas fluid passes through a bottom of the air separation chamber and through the fluid outlet.

    摘要翻译： 描述了包括流体加热室和空气分离室的外部流体加温装置。 流体加热室具有与流体通路连通的流体入口。 与流体通道连通的空气分离室具有流体出口和气体出口。 加热源，例如加热板，邻近流体通道设置，用于将热量传递到流体。 在使用中，空气分离室位于流体加热室和加热源的上方。 流体入口连接到流体源，并且流体出口连接到诸如超滤机器的输出装置。 在加热流体期间产生的气体聚集在空气分离室的顶部并通过气体出口排出，而流体通过空气分离室的底部并通过流体出口。

    Hemodilution cap and methods of use in blood-processing procedures
    2.
    发明申请
    Hemodilution cap and methods of use in blood-processing procedures 审中-公开
    血液稀释帽和血液加工程序中使用的方法

    公开(公告)号：US20030010718A1

    公开(公告)日：2003-01-16

    申请号：US09904709

    申请日：2001-07-12

    申请人： NxStage Medical, Inc.

    发明人： Jeffrey H. Burbank ,  Martin Stillig ,  James M. Brugger

    IPC分类号： A61M001/34 ,  B01D061/00 ,  B01D061/24 ,  B01D061/28 ,  B01D061/14 ,  A61M001/18

    CPC分类号： B01D63/02 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3672 ,  B01D61/20 ,  B01D61/30 ,  B01D2313/21

    摘要： Devices and methods that prevent clotting of blood during blood-processing procedures such as hemofiltration, hemodialysis, hemodiafiltration, and peritoneal dialysis are described. The device comprises a cap and a housing that is shaped to receive a blood filter. The housing has an inlet for blood and may have an outlet for waste and ultrafiltrate. The cap is attached to the housing. The cap has an outlet for blood and a port adjacent the outlet for receiving dilution fluid. Methods of use during blood-processing procedures to provide immediate hemodilution to blood exiting a filter are also described.

    摘要翻译： 描述了在血液加工过程如血液滤过，血液透析，血液透析滤过和腹膜透析期间防止血液凝结的装置和方法。 该装置包括盖和被成形为接收血液过滤器的壳体。 外壳有血液入口，可能有废物和超滤的出口。 盖子连接到外壳。 盖具有用于血液的出口和邻近出口的用于接收稀释液的口。 还描述了在血液处理过程中为离开过滤器的血液即时血液稀释使用的方法。

    Method and aparatus for leak detection in a fluid line
    3.
    发明申请
    Method and aparatus for leak detection in a fluid line 有权
    流体管路中泄漏检测的方法和装置

    公开(公告)号：US20030009123A1

    公开(公告)日：2003-01-09

    申请号：US09900362

    申请日：2001-07-07

    申请人： NxStage Medical, Inc.

    发明人： James M. Brugger ,  Jeffrey H. Burbank ,  Dennis M. Treu

    IPC分类号： A61M037/00 ,  A61F013/15

    CPC分类号： A61M1/3626 ,  A61M1/3656 ,  A61M2205/13

    摘要： One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Such systems draw blood at such a high rate that a loss of integrity in the blood circuit can be catastrophic. The most reliable leak detection method known is the detection of infiltrated air in a blood line, but this only works in blood lines under negative pressure. According to the invention, a leak detector for return lines is provided by periodically generating a negative pressure, which may be brief or at a 50% duty cycle, in the blood return line to draw air into it and thereby reveal the leaks using an air sensor. Although the return line is ordinarily under positive pressure, during the negative pressure cycle, the blood return line draws air through any leaks or disconnects. If air is detected, the system is shut down and an alarm generated.

    摘要翻译： 体外血液治疗如透析自动化中最重要的安全问题之一是出现血液渗漏的风险。 这样的系统以如此高的速度吸取血液，使得血液回路中完整性的丧失可能是灾难性的。 已知的最可靠的泄漏检测方法是检测血液中的渗透空气，但这仅在负压下的血液系统中起作用。 根据本发明，用于返回管线的检漏器是通过在血液回流管线周期性地产生负压，其可以是短暂的或占空比为50％，以将空气吸入其中，从而使用空气泄露泄漏 传感器。 虽然返回线通常处于正压力下，但是在负压循环期间，血液回流管路通过任何泄漏或断开线吸入空气。 如果检测到空气，则系统关闭并产生报警。

    Devices for sterile-filtering fluid and methods of use
    6.
    发明申请
    Devices for sterile-filtering fluid and methods of use 有权
    无菌过滤液的设备及使用方法

    公开(公告)号：US20030010719A1

    公开(公告)日：2003-01-16

    申请号：US09905246

    申请日：2001-07-12

    申请人： NxStage Medical, Inc.

    发明人： James M. Brugger ,  Jeffrey H. Burbank ,  Dennis M. Treu

    IPC分类号： B01D061/00 ,  B01D061/20 ,  B01D061/30 ,  B01D037/00 ,  B01D036/00

    CPC分类号： B01D61/145 ,  A61M1/1692 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/12 ,  A61M2205/705 ,  B01D61/18 ,  C02F1/444

    摘要： A method and device for renal replacement therapy is described that sterile-filters solution that can subsequently be used as a replacement fluid in the same unit. The devices and methods include a pump that can be reversed from its normal forward-pumping direction to sterilize a container of replacement fluid to produce sterile replacement fluid. The sterile replacement fluid is captured in a fluid bag. Upon sterilization of the contents of the container, the pump switches to run in its normal forward-pumping direction. The sterile replacement fluid produced by the previous process is now injected into a patient to perform renal replacement therapy. The waste produced during the renal replacement therapy can be trapped in the container that previously held the non-sterile solution. Systems for sterile filtration and subsequent renal replacement therapy that include pre-connected, sterilized, disposable kits for fluid management and batch collection of sterilized fluid are also described.

    摘要翻译： 描述了用于肾替代治疗的方法和装置，其可以随后在相同单元中用作替换流体的无菌过滤器溶液。 装置和方法包括可以从其正常向前泵送方向反向的泵，以对替换流体的容器进行消毒以产生无菌置换液体。 无菌置换液被捕获在流体袋中。 在消毒容器的内容物时，泵切换到正常的正向泵送方向。 现在将由先前方法产生的无菌置换液注射到患者中进行肾脏替代疗法。 在肾脏替代治疗期间产生的废物可以被捕获在以前保持非无菌溶液的容器中。 还描述了用于无菌过滤和随后的肾脏替代疗法的系统，其包括用于流体管理和无菌液体的批量收集的预先连接的，灭菌的一次性套件。

    Devices and methods for potting a filter for blood processing
    7.
    发明申请
    Devices and methods for potting a filter for blood processing 失效
    灌装过滤器用于血液处理的装置和方法

    公开(公告)号：US20030010702A1

    公开(公告)日：2003-01-16

    申请号：US09904712

    申请日：2001-07-12

    申请人： NxStage Medical, Inc.

    发明人： Martin Stillig ,  Jeffrey H. Burbank ,  James M. Brugger

    IPC分类号： B01D063/00

    CPC分类号： B01D63/022 ,  A61M1/16 ,  B29C70/766 ,  B29L2031/14 ,  B29L2031/755 ,  Y10S264/48

    摘要： A device for potting a filter is described. The device comprises a housing having a first hole in the first region communicating between the surface and the lumen, and a second hole in the second region communicating between the surface and the lumen. A ridge extends around the first hole and the second hole to define a trough for receipt of a flowable potting material. During the manufacture of the filter assembly, the housing is rotated about an axis that bisects the housing and is perpendicular to an axis of the lumen, a flowable material is placed on the surface of the housing, a portion of the flowable material flows toward the first hole, is retained by the ridge, and passes through the first hole, and a portion of the flowable material flows toward the second hole, is retained by the ridge, and passes through the second hole.

    摘要翻译： 描述了用于灌封过滤器的装置。 所述装置包括壳体，所述壳体在所述第一区域中具有在所述表面和所述内腔之间连通的第一孔，以及所述第二区域中的在所述表面和所述内腔之间连通的第二孔。 脊围绕第一孔和第二孔延伸以限定用于接收可流动灌封材料的槽。 在过滤器组件的制造期间，壳体围绕平分壳体并垂直于管腔的轴线的轴线旋转，可流动材料被放置在壳体的表面上，可流动材料的一部分朝向 第一孔由脊保持，并且通过第一孔，并且可流动材料的一部分朝向第二孔流动，被脊保持并穿过第二孔。