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1.
公开(公告)号:US20210046154A1
公开(公告)日:2021-02-18
申请号:US16977628
申请日:2019-03-05
申请人: ONCOIMMUNE, INC. , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , INSTITUTE OF BIOPHYSICS, CHINESE ACADEMY OF SCIENCES , KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES
发明人: Yang Liu , Pan Zhang , Lishan Su , Yong-Tang Zheng , Liguo Zhang
摘要: The present invention relates to a method of treating, mitigating, minimizing, or preventing HIV-1/AIDS by administering a CD24 protein to a subject in need thereof. Also provided herein is use of a CD24 protein in the manufacture of a medicament for treating HIV-1/AIDS. Further, provided is a pharmaceutical composition comprising a pharmaceutically acceptable amount of a CD24 protein.
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公开(公告)号:US20210214458A1
公开(公告)日:2021-07-15
申请号:US17055248
申请日:2019-05-13
发明人: Yang Liu , Pan Zheng , Rhonda Flores , Hung-Yen Chou , Zhihong Xue , Peiying Ye , Martin Devenport
摘要: Provided herein are anti-CD24 antibodies that selectively bind human CD24 expressed in cancer cells, but not human CD24 expressed in non-cancerous cells, and the use of such antibodies in cancer therapy.
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公开(公告)号:US20180177841A1
公开(公告)日:2018-06-28
申请号:US15839643
申请日:2017-12-12
申请人: OncoImmune, Inc.
发明人: Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号: A61K38/07 , A61K31/565 , A61K31/395 , A61K31/4355
CPC分类号: A61K38/07 , A61K31/00 , A61K31/395 , A61K31/4355 , A61K31/498 , A61K31/565 , A61K38/08 , A61K45/06 , A61K2300/00
摘要: The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
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公开(公告)号:US20170239315A1
公开(公告)日:2017-08-24
申请号:US15448737
申请日:2017-03-03
申请人: OncoImmune, Inc.
发明人: Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号: A61K38/07 , A61K31/395 , A61K31/4355 , A61K31/565
CPC分类号: A61K38/07 , A61K31/00 , A61K31/395 , A61K31/4355 , A61K31/498 , A61K31/565 , A61K38/08 , A61K45/06 , A61K2300/00
摘要: The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
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5.
公开(公告)号:US08895022B2
公开(公告)日:2014-11-25
申请号:US14055609
申请日:2013-10-16
申请人: OncoImmune, Inc.
发明人: Xincheng Zheng , Wei Wu , Yang Liu , Pan Zheng
IPC分类号: C07K14/435 , A61K39/00 , A61K38/00 , C07K14/47 , C07K19/00 , C07K14/705
CPC分类号: C07K14/70596 , C07K14/435 , C07K14/47 , C07K19/00 , C07K2319/30
摘要: Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian immunoglobulin.
摘要翻译: 本文提供CD24蛋白。 CD24蛋白可以包括成熟的人或小鼠CD24,以及哺乳动物免疫球蛋白的N-或C-末端融合部分。
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6.
公开(公告)号:US20210228680A1
公开(公告)日:2021-07-29
申请号:US15734961
申请日:2019-06-03
申请人: ONCOIMMUNE, INC.
发明人: Yang Liu , Pan Zheng , Martin Devenport
摘要: The present invention relates to the use of a CD24 protein for preventing or treating Graft versus Host Disease and mucositis.
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公开(公告)号:US20190255140A1
公开(公告)日:2019-08-22
申请号:US16294615
申请日:2019-03-06
申请人: OncoImmune, Inc.
发明人: Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号: A61K38/07 , A61K38/08 , A61K31/4355 , A61K31/00 , A61K31/395 , A61K31/565 , A61K31/498 , A61K45/06
摘要: The present invention relates to treating, a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIT inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIE inhibitor.
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公开(公告)号:US09611309B2
公开(公告)日:2017-04-04
申请号:US14519745
申请日:2014-10-21
申请人: OncoImmune, Inc.
发明人: Xincheng Zheng , Wei Wu , Yang Liu , Pan Zheng
IPC分类号: C07K19/00 , C07K14/705 , C07K14/435 , C07K14/47
CPC分类号: C07K14/70596 , C07K14/435 , C07K14/47 , C07K19/00 , C07K2319/30
摘要: Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian immunoglobulin.
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公开(公告)号:US11571461B2
公开(公告)日:2023-02-07
申请号:US16491708
申请日:2018-03-06
申请人: ONCOIMMUNE, INC.
发明人: Yang Liu , Pan Zheng , Martin Devenport
IPC分类号: C07K14/47 , C07K14/475 , C07K14/705 , C07K16/28 , C07K19/00 , A61K38/17 , A61K38/18 , A61K39/395 , A61P37/06
摘要: The present invention relates to the use of a CD24 protein for treating Systemic Lupus Erythematosus (Lupus, SLE).
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10.
公开(公告)号:US11547741B2
公开(公告)日:2023-01-10
申请号:US16614660
申请日:2018-05-21
发明人: Yang Liu , Pan Zheng , Martin Devenport , Mingyue Liu
IPC分类号: A61K38/17 , A61P37/06 , C07K14/705
摘要: The present invention relates to a CD24 protein for treating immune-related adverse events (irAEs) associated with cancer immunotherapy. Provided herein is a method of treating, mitigating, minimizing, or preventing immunerelated adverse events (irAEs) associated with a cancer immunotherapy by administering a CD24 protein to a subject in need thereof. The irAE may be diarrhea or another gastrointestinal disorder, pure red cell aplasia, microcytic anemia, lupus, autoimmune nephritism, autoimmune hepatitis, pneumonitis, myocarditis, pericarditis, endocrinopathy, Addison's disease, hypogonadism, Sjogren's syndrome, or type I diabetes. The CCD24 protein may comprise a mature human CD24 or a variant thereof.
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