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公开(公告)号:US20210008172A1
公开(公告)日:2021-01-14
申请号:US16924810
申请日:2020-07-09
申请人: OPKO Biologics Ltd.
摘要: Compositions which include polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus or amino terminus of an insulin-like growth factor 1 (IGF-1) or IGF-1 variant. Polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.