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公开(公告)号:US20200291058A1
公开(公告)日:2020-09-17
申请号:US16889624
申请日:2020-06-01
发明人: Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号:US20210023095A1
公开(公告)日:2021-01-28
申请号:US16065625
申请日:2016-12-22
发明人: Daqing SUN , Lawrence R. MCGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Haiying ZHOU , Minna Delarae BALBAS , Valeria R. FANTIN
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号:US20230096870A1
公开(公告)日:2023-03-30
申请号:US17887777
申请日:2022-08-15
发明人: Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号:US20210395295A1
公开(公告)日:2021-12-23
申请号:US17404493
申请日:2021-08-17
发明人: Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Haiying ZHOU , Minna Delarae BALBAS , Valeria R. FANTIN
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号:US20210379084A1
公开(公告)日:2021-12-09
申请号:US17381430
申请日:2021-07-21
发明人: Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Haiying ZHOU , Minna Delarae BALBAS , Valeria R. FANTIN
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号:US20190218246A1
公开(公告)日:2019-07-18
申请号:US16365422
申请日:2019-03-26
发明人: Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
CPC分类号: C07J41/0083 , A61P5/46 , A61P35/00 , C07J17/00 , C07J21/008 , C07J31/006 , C07J41/0088 , C07J43/003 , C07J71/001 , C07J71/0015
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号:US20210017220A1
公开(公告)日:2021-01-21
申请号:US16065626
申请日:2016-12-22
发明人: Daqing SUN , Lawrence R. MCGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Haiying ZHOU , Minna Delarae BALBAS , Valeria R. FANTIN
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号:US20210017219A1
公开(公告)日:2021-01-21
申请号:US17039794
申请日:2020-09-30
发明人: Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号:US20210002324A1
公开(公告)日:2021-01-07
申请号:US16065627
申请日:2016-12-22
发明人: Daqing SUN , Lawrence R. MCGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Haiying ZHOU , Minna Delarae BALBAS , Valeria R. FANTIN
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号:US20200055892A1
公开(公告)日:2020-02-20
申请号:US16562204
申请日:2019-09-05
发明人: Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
摘要: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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