公开(公告)号：US09630947B2

公开(公告)日：2017-04-25

申请号：US14692434

申请日：2015-04-21

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Masaki Suzuki ,  Kazumi Kondo ,  Muneaki Kurimura ,  Krishna Reddy Valluru ,  Akira Takahashi ,  Takeshi Kuroda ,  Haruka Takahashi ,  Tae Fukushima ,  Shin Miyamura ,  Indranath Ghosh ,  Abhishek Dogra ,  Geraldine Harriman ,  Amy Elder ,  Satoshi Shimizu ,  Kevin J. Hodgetts ,  Jason S. Newcom

IPC分类号： A01N43/54 ,  A61K31/517 ,  C07D401/00 ,  C07D403/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  A61K45/06

CPC分类号： C07D401/04 ,  A61K31/517 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

摘要： Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP), such as those of formula (III), and composition thereof are described herein. Exemplary disorders include schizophrenia and cognitive deficit.

公开(公告)号：US20170217923A1

公开(公告)日：2017-08-03

申请号：US15456927

申请日：2017-03-13

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Masaki Suzuki ,  Kazumi Kondo ,  Muneaki Kurimura ,  Krishna Reddy Valluru ,  Akira Takahashi ,  Takeshi Kuroda ,  Haruka Takahashi ,  Tae Fukushima ,  Shin Miyamura ,  Indranath Ghosh ,  Abhishek Dogra ,  Geraldine Harriman ,  Amy Elder ,  Satoshi Shimizu ,  Kevin J. Hodgetts ,  Jason S. Newcom

IPC分类号： C07D401/04 ,  C07D409/14 ,  C07D405/14 ,  C07D417/14 ,  C07D401/14 ,  C07D413/14

CPC分类号： C07D401/04 ,  A61K31/517 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

摘要： Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP) are described herein. Exemplary disorders include schizophrenia and cognitive deficit.

公开(公告)号：US10800758B2

公开(公告)日：2020-10-13

申请号：US16471998

申请日：2018-05-31

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Tomoichi Shinohara ,  Shin Iwata ,  Kenta Arai ,  Nobuaki Ito ,  Masaki Suzuki

IPC分类号： C07D403/04 ,  C07D401/14 ,  C07F7/08 ,  A61P25/08

摘要： The present invention provides a novel pyrimidine compound represented by Formula [I] and a salt thereof: [in the formula, the symbols are as defined in the specification], which is useful for treating, preventing and/or diagnosing seizure and the like in disease involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), as well as a medical use therefor.